Graft material and method of use thereof
The present disclosure relates to a graft material including a reinforced layer and to implantable medical devices including such a graft material. The invention also relates to methods of using and manufacturing such graft materials and devices. In one embodiment the implantable medical device is a stent graft.
1. A stent graft comprising:
an expandable stent having a luminal and an abluminal surface; and
a graft disposed on at least one of the luminal and the abluminal surface;
wherein the graft comprises a first layer comprising fibers of a supramolecular polymer-colloidal hydrogel.
2. The stent-graft of claim 1 , wherein the fibers of a supramolecular polymer-colloidal hydrogel are woven, knitted or braided.
3. The stent-graft of claim 1 , wherein the fibers of a supramolecular polymer-colloidal hydrogel are imbedded in a polyurethane.
4. The stent graft of claim 1 , wherein the graft comprises a plurality of stacked layers comprising fibers of the supramolecular polymer-colloidal hydrogel wherein at least one of the plurality of stacked layers is separated from another of the plurality of stacked layers by a layer comprising electro-spun polytetrafluoroethylene or expanded polytetrafluoroethylene.
5. The stent graft of claim 1 , wherein the first layer is disposed on the abluminal surface of the stent.
6. The stent graft of claim 1 , wherein the first layer attaches to the expandable stent by an adhesive or a suture.
7. The stent graft of claim 1 , wherein the graft further comprises a second layer comprising electro-spun polytetrafluoroethylene or expanded polytetrafluoroethylene, wherein the second layer is disposed on the first layer.
8. The stent graft of claim 7 , wherein the graft further comprises a third layer comprising electro-spun polytetrafluoroethylene or expanded polytetrafluoroethylene, wherein the first layer is disposed between the second layer and the third layer.
9. The stent graft of claim 1 , wherein the supramolecular polymer-colloidal hydrogel comprises methyl viologen-functionalized polymer-grafted silica nanoparticles, a semicrystalline polymer in the form of a hydroxyethyl cellulose derivative and cucurbit[8]uril, wherein the semicrystalline polymer and the methyl viologen-functionalized polymer-grafted silica nanoparticles are cross-linked by the cucurbit[8]uril.
10. The stent graft of claim 9 , wherein hydroxyethyl cellulose derivative is naphthalene isocyanate functionalized hydroxyethylcellulose.
11. The stent graft of claim 1 , wherein the expandable stent comprises a plurality of interconnected struts at least partially imbedded within the first layer.
12. The stent graft of claim 11 , wherein the struts comprise a material selected from the group consisting of nylon, a nickel-titanium alloy, stainless steel and a cobalt-chromium alloy.
13. An expandable stent graft material comprising a first layer comprising fibers of a supramolecular polymer-colloidal hydrogel.
14. The graft material of claim 13 , wherein the fibers of a supramolecular polymer-colloidal hydrogel are woven, knitted or braided.
15. The graft material of claim 13 , wherein the fibers of a supramolecular polymer-colloidal hydrogel are imbedded in a polyurethane.
16. The graft material of claim 13 , further comprising a second layer comprising electro-spun polytetrafluoroethylene or expanded polytetrafluoroethylene, wherein the second layer is disposed on the first layer.
17. The graft material of claim 16 , wherein the graft material further comprises a third layer comprising electro-spun polytetrafluoroethylene or expanded polytetrafluoroethylene, wherein the first layer is disposed between the second layer and the third layer.
18. The graft material of claim 13 , wherein the supramolecular polymer-colloidal hydrogel comprises methyl viologen-functionalized polymer-grafted silica nanoparticles, a semicrystalline polymer in the form of a hydroxyethyl cellulose derivative and cucurbit[8]uril, wherein the semicrystalline polymer and the methyl viologen-functionalized polymer-grafted silica nanoparticles are cross-linked by the cucurbit[8]uril.
19. The graft material of claim 18 , wherein hydroxyethyl cellulose derivative is naphthalene isocyanate functionalized hydroxyethylcellulose.
20. A stent graft comprising:
an expandable stent comprising a tubular body with a lumen extending therethrough and having a luminal and an abluminal surface; and
a graft disposed on at least one of the luminal and the abluminal surface;
wherein the graft comprises:
a first layer comprising fibers of a supramolecular polymer-colloidal hydrogel;
a second layer comprising electro-spun polytetrafluoroethylene or expanded polytetrafluoroethylene; and
a third layer comprising electro-spun polytetrafluoroethylene or expanded polytetrafluoroethylene,
wherein the first layer is disposed between the second layer and the third layer.