Isoquinoline-steroid conjugates and uses thereof
Provided herein are compounds and pharmaceutical compositions useful in modulating kinase activity, and related diseases. Also provided herein are methods of treating an eye disease or disorder in a subject. Also provided herein are methods of reducing intraocular pressure in a subject. Also provided herein are methods of modulating kinase activity in a cell. Also provided herein are methods of making the compounds provided herein, and compounds useful for the preparation of the compounds provided herein.
1. A compound selected from:
or a pharmaceutically acceptable salt thereof.
2. A compound having the formula:
R 8 —R 10 —R 11
or a pharmaceutically acceptable salt thereof,
wherein R 8 is
R 10 is
and R 11 is
3. A compound having the formula:
R 8 —R 10 —R 11
or a pharmaceutically acceptable salt thereof,
wherein
R 8 is
R 10 is
and
R 11 is
4. A compound having the formula:
R 8 —R 10 —R 11
or a pharmaceutically acceptable salt thereof,
wherein
R 8 is
R 10 is
and
R 11 is
5. A compound having the formula:
R 8 —R 10 —R 11
or a pharmaceutically acceptable salt thereof,
wherein
R 8 is
R 10 is
and
R 11 is
6. A compound having the formula:
R 8 —R 10 —R 11
or a pharmaceutically acceptable salt thereof,
wherein
R 8 is
R 10 is
and
R 11 is
7. A compound having the formula:
R 8 —R 10 —R 11
or a pharmaceutically acceptable salt thereof,
wherein
R 8 is
R 10 is
and
R 11 is
8. A compound having the formula:
R 8 —R 10 —R 11
or a pharmaceutically acceptable salt thereof,
wherein
R 8 is
R 10 is
and
R 11 is
9. A compound having the formula:
R 8 —R 10 -R 11
or a pharmaceutically acceptable salt thereof,
wherein
R 8 is
R 10 is
and
R 11 is
10. A compound having the formula:
R 8 —R 10 —R 11
or a pharmaceutically acceptable salt thereof,
wherein
R 8 is
R 10 is
and
R 11 is
11. A composition, comprising the compound of claim 1 .
12. A composition, comprising the compound of claim 2 .
13. A composition, comprising the compound of claim 3 .
14. A composition, comprising the compound of claim 4 .
15. A composition, comprising the compound of claim 5 .
16. A composition, comprising the compound of claim 6 .
17. A composition, comprising the compound of claim 7 .
18. A composition, comprising the compound of claim 8 .
19. A composition, comprising the compound of claim 9 .
20. A composition, comprising the compound of claim 10 .
21. A pharmaceutical composition, comprising the compound of claim 1 , and a pharmaceutically acceptable carrier.
22. A pharmaceutical composition, comprising the compound of claim 2 , and a pharmaceutically acceptable carrier.
23. A pharmaceutical composition, comprising the compound of claim 3 , and a pharmaceutically acceptable carrier.
24. A pharmaceutical composition, comprising the compound of claim 4 , and a pharmaceutically acceptable carrier.
25. A pharmaceutical composition, comprising the compound of claim 5 , and a pharmaceutically acceptable carrier.
26. A pharmaceutical composition, comprising the compound of claim 6 , and a pharmaceutically acceptable carrier.
27. A pharmaceutical composition, comprising the compound of claim 7 , and a pharmaceutically acceptable carrier.
28. A pharmaceutical composition, comprising the compound of claim 8 , and a pharmaceutically acceptable carrier.
29. A pharmaceutical composition, comprising the compound of claim 9 , and a pharmaceutically acceptable carrier.
30. A pharmaceutical composition, comprising the compound of claim 10 , and a pharmaceutically acceptable carrier.