Treatment of autism and autism spectrum disorders with biotin compositions

1. A method of treatment comprising assessing the biotin status of an individual with an autism spectrum disorder and subsequently providing magnesium biotinate in an amount between 10 mg/day to 1000 mg/day, to the individual to treat the autism spectrum disorder.

2. The method of claim 1 , wherein the assessing the biotin status of the individual with an autism spectrum disorder comprises obtaining samples from the individual and testing for markers associated with biotin deficiency.

3. The method of claim 2 , wherein the samples are obtained from blood, serum, peripheral blood mononuclear cell (PBMC), saliva, urine, feces or sweat from the individual with an autism spectrum disorder.

4. The method of claim 2 , wherein the samples are tested for markers indicative of impaired carboxylases.

5. The method of claim 4 , wherein the samples are tested for impaired propionyl-CoA carboxylase (PCC) or pyruvate carboxylase (PC).

6. The method of claim 5 , wherein the samples are tested for amino acids found at abnormal levels due to impaired PCC or PC or other carboxylase.

7. The method of claim 2 , wherein the samples are tested for biotin, propionic acid, pyruvate, or lactate.

8. The method of claim 2 , wherein the samples are tested for isoleucine, methionine, threonine, and valine.

9. The method of claim 2 , wherein the samples are tested for ratios of one amino acid over another.

10. The method of claim 2 , wherein the samples are tested for white blood cell count.

11. The method of claim 2 , wherein the samples are tested for mitochondrial function.

12. A method of treating an autism spectrum disorder comprising administering magnesium biotinate in an amount between 10 mg/day to 1000 mg/day, to an individual diagnosed with an autism spectrum disorder.

13. The method of claim 12 , wherein the type of autism spectrum disorder to be treated is related to low biotin levels, impaired carboxylase function, increased propionic acid levels, or increased levels of isoleucine, methionine, threonine, and/or valine.

14. The method of claim 12 , wherein the magnesium biotinate can be provided as a drug, supplement, medical food, food or biologic.