Botanical modulator of metabolic disorders
Plant-based inhibitors of MMP-9 that also function as PPAR-γ agonists, and the use of such plant-based inhibitors/agonists in modulating metabolic disorders is disclosed. The plant-based inhibitor/agonist is at least an extract obtained from the leaf of the genus Vaccinium.
1. A method of treating a metabolic disorder in a subject comprising:
administering to a subject in need thereof an effective amount of a composition comprising a botanical extract of a leaf of Vaccinium macrocarpon,
wherein the botanical extract is present in the composition in an amount of about 15.0 μg/mL to about 750.0 μg/mL,
wherein the botanical extract is free of anthocyanins, and
wherein the botanical extract has a flavonoid content of at least about twenty times greater than that of the fruit of Vaccinium macrocarpon.
2. The method according to claim 1 , wherein the composition exhibits MMP-9 inhibition.
3. The method according to claim 1 , wherein the composition exhibits PPAR-γ agonist activity.
4. The method according to claim 1 , wherein the composition is administered in form for oral ingestion.
5. The method according to claim 1 , wherein the composition is a dietary supplement.
6. The method according to claim 5 , wherein the dietary supplement further comprises a carrier.
7. The method according to claim 1 , wherein the composition is a topical composition.