MULTI-SITE BODY FLUID SAMPLING AND ANALYSIS CARTRIDGE
An arrangement includes a housing, a plurality of sampling and analysis sites contained within the housing, each of the sampling and analysis sites having a skin-penetration member having a first end configured to pierce the skin, and an inner lumen in communication with the first end, an actuator operatively associated with the skin-penetration member, and an analyte quantification member in fluid communication with the inner lumen of the skin-penetration member. Integrated devices including such arrangements are also described.
1 - 40 : (canceled)
41 : An arrangement comprising:
a cartridge, wherein the cartridge comprises:
a frame comprising a plurality of openings; and
a plurality of sampling and analysis sites contained within the cartridge, each sampling and analysis site aligned with an opening of the plurality of openings in the frame and comprising a skin-penetration member, an actuator, and an analyte quantification member; and
a triggering mechanism advanceable through each opening to actuate the corresponding sampling and analysis site to drive the skin-penetration member into skin.
42 : The arrangement of claim 41 , wherein each of the sampling and analysis sites further comprises a hub coupled to the skin-penetration member.
43 : The arrangement of claim 42 , wherein the actuator is coupled to the hub.
44 : The arrangement of claim 43 , wherein the triggering mechanism is advanceable through the corresponding opening to contact the hub to actuate the corresponding sampling and analysis site.
45 : The arrangement of claim 42 , wherein the hub comprises a locking feature.
46 : The arrangement of claim 45 , wherein the locking feature comprises one of a projection and a groove.
47 : The arrangement of claim 1 , wherein the triggering mechanism is advanceable through the opening to contact the corresponding actuator.
48 : The arrangement of claim 41 , wherein the actuator comprises a spring.
49 : The arrangement of claim 48 , wherein the spring is a torsional spring configured to move the skin-penetration member in an arcuate path.
50 : The arrangement of claim 41 , wherein each of the plurality of openings is sealed.
51 : The arrangement of claim 41 , wherein the cartridge further comprises a seal and wherein the seal comprises a solid flexible membrane, an apertured membrane in combination with a secondary seal, or a pierceable membrane.
52 : The arrangement of claim 51 , wherein the seal is configured to maintain sealing after passage of the triggering mechanism therethrough.
53 : The arrangement of claim 41 , wherein the cartridge is disposable.
54 : The arrangement of claim 41 , wherein the skin-penetration member comprises a lumen therethrough.
55 : The arrangement of claim 41 , wherein each of the sampling and analysis sites are in a pre-cocked position prior to actuation.
56 : An integrated body fluid sampling and analysis device comprising the arrangement of claim 41 .
57 : A method of operating a body fluid sampling device comprising:
providing a body fluid sampling device comprising a cartridge and a triggering mechanism, wherein the cartridge comprises:
a frame comprising a plurality of openings; and
a plurality of sampling and analysis sites contained within the cartridge, each sampling and analysis site aligned with an opening of the plurality of openings in the frame and comprising a skin-penetration member, an actuator, and an analyte quantification member; and
advancing a portion of the triggering mechanism through one of the plurality of openings, wherein advancing a portion of the triggering mechanism through the opening actuates the corresponding sampling and analysis site.
58 : The method of claim 57 , wherein actuating the corresponding sampling and analysis site comprises releasing the corresponding sampling and analysis site and allowing the corresponding actuator to move the corresponding skin-penetration member toward skin of a user.
59 : The method of claim 58 , wherein the actuator moves the corresponding skin-penetration member in an arcuate path toward the skin of the user.
60 : The method of claim 57 , wherein releasing the corresponding sampling and analysis site comprises applying a force to the hub with the triggering mechanism.
61 : The method of claim 60 , wherein applying a force to the hub disengages a locking feature on the hub.
62 : The method of claim 57 , wherein advancing a portion of the triggering mechanism through one of the plurality of openings further comprises advancing the portion of the triggering mechanism through each of the plurality of openings.
63 : The method of claim 57 , wherein each of the plurality of sampling and analysis sites is in a pre-cocked position prior to actuation.