COMBINATION TREATMENT OF CD38-EXPRESSING TUMORS
The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non-corticosteroid chemotherapeutic agent.
1 - 73 . (canceled)
74 . A method for treating rheumatoid arthritis in a subject comprising administering to the subject an antibody which binds to CD38 and comprises light and heavy chain variable region CDRs set forth in SEQ ID NOs: 13, 14, and 15 and SEQ ID NOs: 18, 19, and 20, respectively.
75 . A method for treating rheumatoid arthritis in a subject comprising administering to the subject an antibody which binds to CD38 and comprises light and heavy chain variable region sequences which are at least 90% identical to SEQ ID NOs: 12 and 17, respectively.
76 . The method of claim 74 , wherein the antibody is internalized by CD38 expressing cells.
77 . The method of claim 74 , wherein said antibody does not induce release of significant IL-6 by human monocytes or peripheral blood mononuclear cells.
78 . The method of claim 74 , wherein said antibody does not induce release of detectable IFN-γ by human T cells or peripheral blood mononuclear cells.
79 . The method of claim 74 , wherein the antibody is a monoclonal antibody.
80 . The method of claim 74 , wherein the antibody is a human monoclonal antibody.
81 . The method of claim 74 , wherein the antibody is a full length IgG1, IgG2, IgG3, IgG4, IgD, IgA, IgE, or IgM antibody.
82 . The method of claim 74 , wherein the antibody is an antibody fragment or a single-chain antibody.
83 . The method of claim 74 , wherein the antibody is conjugated to a cytotoxic agent, a radioisotope, or a drug.
84 . The method of claim 74 , further comprising administering at least one corticosteroid.
85 . The method of claim 74 , further comprising administering an anti-inflammatory agent.
86 . The method of claim 74 , further comprising administering an immunosuppressive agent.
87 . The method of claim 74 , further comprising administering an immunomodulatory agent.
88 . A method for treating multiple myeloma in a subject comprising administering to the subject an antibody which binds to CD38 and comprises light and heavy chain variable region CDRs set forth in SEQ ID NOs: 13, 14, and 15 and SEQ ID NOs: 18, 19, and 20, respectively.