Granted Patent B2

US 12,343,108 · App. 16/570,426 · Granted Jul 1, 2025

Inventors: Marcelo M. Lamego (Cupertino, CA); Abraham Mazda Kiani (San Juan Capistrano, CA); Don Sanders (Irvine, CA); Jeroen Poeze (Rancho Santa Margarita, CA); Massi Joe E Kiani (Laguna Niguel, CA); Anthony Amir Davia (Laguna Beach, CA)

Assignee: Willow Laboratories, Inc.

A61B5/0022A61B5/14551G16H50/30A61B5/7235

Abstract

Claims (75)

1. A physiological monitoring system comprising:

an optical sensor configured to provide a first data stream responsive to at least one of: pulsatile blood flow of a patient, or a blood constituent parameter of the patient;

a blood pressure sensor configured to provide a second data stream responsive to blood pressure of the patient;

one or more patient monitors configured to receive at least the first and second data streams; and

one or more processors separate from the one or more patient monitors and configured to communicate with the one or more patient monitors and execute program instructions to cause the one or more processors to:

communicate with the one or more patient monitors to receive information responsive to at least the first and second data streams and responsive to changes in one or more physiological conditions of the patient;

process the information so as to derive a plurality of parameters responsive to the changes in the one or more physiological conditions of the patient;

determine a plurality of trends in each of the plurality of parameters, wherein determining the plurality of trends includes:

identifying, based on a type of a first parameter of the plurality of parameters, a first predetermined time interval that is specific to the first parameter;

identifying, based on a type of a second parameter of the plurality of parameters, a second predetermined time interval that is specific to the second parameter and that is different from the first predetermined time interval;

determining a trend of the first parameter over the first predetermined time interval, wherein the trend of the first parameter indicates either rising values of the first parameter over the first predetermined time interval or falling values of the first parameter over the first predetermined time interval; and

determining a trend of the second parameter over the second predetermined time interval, wherein the trend of the second parameter indicates either rising values of the second parameter over the second predetermined time interval or falling values of the second parameter over the second predetermined time interval;

combine the plurality of determined trends, including the trend of the first parameter over the first predetermined time interval, and further including the trend of the second parameter over the second predetermined time interval that is different from the first predetermined time interval, to derive a medical index, the medical index indicating a medical condition of the patient; and

communicate the medical index to at least one of the one or more patient monitors,

wherein the one or more patient monitors are configured to:

determine whether communication with the one or more processors is available or not available;

responsive to determining that communication with the one or more processors is not available, temporarily process at least the first and second data streams locally at the one or more patient monitors; and

responsive to determining that communication with the one or more processors is available, communicate the information responsive to at least the first and second data streams to the one or more processors.

2. The physiological monitoring system according to claim 1 , wherein the one or more processors are configured to execute the program instructions to further cause the one or more processors to:

cause display of the medical index on at least one of: the at least one of the patient monitors, or a smart cellular telephone.

3. The physiological monitoring system according to claim 2 , wherein the medical index relates to at least one of: dehydration, renal insufficiency, over hydration, gastrointestinal bleeding, congestive heart failure exacerbation, or cardiovascular risk.

4. The physiological monitoring system according to claim 3 , wherein the one or more processors are configured to execute the program instructions to further cause the one or more processors to:

determine that required parameters for deriving the medical index include the plurality of parameters, and that the plurality of parameters are available for deriving the medical index; and

determine that most-recent parameter measurements associated with the plurality of parameters satisfy a time frame mismatch tolerance associated with the medical index.

5. The physiological monitoring system according to claim 4 , wherein determining the trends and deriving the medical index are performed in response to determining that most-recent parameter measurements associated with the plurality of parameters satisfy the time frame mismatch tolerance associated with the medical index.

6. The physiological monitoring system according to claim 5 , wherein the one or more processors are configured to execute the program instructions to further cause the one or more processors to:

in response to determining that the most-recent parameter measurements associated with the plurality of parameters do not satisfy the time frame mismatch tolerance:

not derive the medical index; and

cause the at least one of the patient monitor or the smart cellular telephone to not display the medical index.

7. The physiological monitoring system according to claim 6 , wherein causing the at least one of the patient monitor or the smart cellular telephone to not display the medical index further includes displaying dashes in a location on the at least one of the patient monitor or the smart cellular telephone where the medical index otherwise would be displayed.

8. The physiological monitoring system according to claim 1 , wherein the plurality of parameters include:

a first parameter indicative of hemoglobin (Hgb) of the patient,

a second parameter indicative of blood urea nitrogen (BUN) of the patient,

a third parameter indicative of creatinine (Cr) of the patient,

a fourth parameter indicative of a plethysmograph variability index (PVI) of the patient, and

a fifth parameter indicative of a blood pressure (BP) of the patient.

9. The physiological monitoring system according to claim 1 , wherein the plurality of parameters include:

a first parameter indicative of total cholesterol (Chol) of the patient,

a second parameter indicative of high-density lipoprotein (HDL) of the patient,

a third parameter indicative of Chol/HDL of the patient,

a fourth parameter indicative of triglycerides (Trig) of the patient, and

a fifth parameter indicative of a blood pressure (BP) of the patient.

10. The physiological monitoring system according to claim 1 , wherein the plurality of parameters include at least one of: hemoglobin (Hgb), blood urea nitrogen (BUN), creatinine (Cr), plethysmograph variability index (PVI), blood pressure (BP), total cholesterol (Chol), high-density lipoprotein (HDL), Chol/HDL, triglycerides (Trig), blood-constituents, oxygen saturation (SpO 2 ), respiration rate (RR), temperature, heart rate (HR), or electrocardiogram (ECG).

11. A physiological monitoring method comprising:

receiving, from an optical sensor in communication with a patient and via a patient monitor, first sensor data responsive to at least one of: pulsatile blood flow of the patient, or a blood constituent parameter of the patient;

receiving, from a blood pressure sensor in communication with the patient and via the patient monitor, second sensor data responsive to blood pressure of the patient;

by one or more processors, separate from the patient monitor, executing program instructions:

communicating with the patient monitor to receive at least the first and second sensor data responsive to changes in one or more physiological conditions of the patient;

processing at least the first and second sensor data so as to derive a plurality of parameters responsive to the changes in the one or more physiological conditions of the patient;

determining a plurality of trends in each of the plurality of parameters, wherein determining the plurality of trends includes:

identifying, based on a type of a first parameter of the plurality of parameters, a first predetermined time interval that is specific to the first parameter;

identifying, based on a type of a second parameter of the plurality of parameters, a second predetermined time interval that is specific to the second first parameter and that is different from the first predetermined time interval;

determining a trend of the first parameter over the first predetermined time interval, wherein the trend of the first parameter indicates either rising values of the first parameter over the first predetermined time interval or falling values of the first parameter over the first predetermined time interval; and

determining a trend of the second parameter over the second predetermined time interval, wherein the trend of the second parameter indicates either rising values of the second parameter over the second predetermined time interval or falling values of the second parameter over the second predetermined time interval;

combining the plurality of determined trends, including the trend of the first parameter over the first predetermined time interval, and further including the trend of the second parameter over the second predetermined time interval that is different from the first predetermined time interval, to derive a medical index, the medical index indicating a medical condition of the patient; and

communicating the medical index to the patient monitor; and

by the patient monitor:

determining whether communication with the one or more processors is available or not available;

responsive to determining that communication with the one or more processors is not available, temporarily processing at least the first and second sensor data locally at the patient monitor; and

responsive to determining that communication with the one or more processors is available, communicating at least the first and second sensor data to the one or more processors.

12. The physiological monitoring method according to claim 11 further comprising:

causing display of the medical index on at least one of the patient monitor or a smart cellular telephone.

13. The physiological monitoring method according to claim 12 , wherein the medical index includes an indication of at least one of: dehydration, renal insufficiency, over hydration, gastrointestinal bleeding, or congestive heart failure exacerbation.

14. The physiological monitoring method according to claim 13 further comprising:

by the one or more processors executing program instructions:

determining that required parameters for deriving the medical index include the plurality of parameters, and that the plurality of parameters are available for deriving the medical index; and

determining that most-recent parameter measurements associated with the plurality of parameters satisfy a time frame mismatch tolerance associated with the medical index.

15. The physiological monitoring method according to claim 14 , wherein determining the trends and deriving the medical index are performed in response to determining that most-recent parameter measurements associated with the plurality of parameters satisfy the time frame mismatch tolerance associated with the medical index.

16. The physiological monitoring method according to claim 15 further comprising:

by the one or more processors executing program instructions:

in response to determining that the most-recent parameter measurements associated with the plurality of parameters do not satisfy the time frame mismatch tolerance:

not deriving the medical index; and

causing the at least one of the patient monitor or the smart cellular telephone to not display the medical index.

17. The physiological monitoring method according to claim 16 , wherein causing the at least one of the patient monitor or the smart cellular telephone to not display the medical index further includes causing the at least one of the patient monitor or the smart cellular telephone to display dashes in a location on the monitor where the medical index otherwise would be displayed.

18. The physiological monitoring method according to claim 11 , wherein the plurality of parameters include at least one of: hemoglobin (Hgb), blood urea nitrogen (BUN), creatinine (Cr), plethysmograph variability index (PVI), blood pressure (BP), total cholesterol (Chol), high-density lipoprotein (HDL), Chol/HDL, triglycerides (Trig), blood-constituents, oxygen saturation (SpO 2 ), respiration rate (RR), temperature, heart rate (HR), or electrocardiogram (ECG).

Assignments (3)

Continuity (6)

References Cited (400)