Drugs and compositions for the treatment of ocular disorders
The present invention provides new prodrugs of therapeutically active compounds, including oligomeric prodrugs, and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (IOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.
1. A compound of the formula:
or a pharmaceutically acceptable salt thereof;
wherein x and x′ are 1; and
y and y′ are selected from 2, 3, 4, 5, and 6.
2. The compound of claim 1 , wherein y and y′ are independently selected from 2, 3, and 4, or a pharmaceutically acceptable salt thereof.
3. The compound of claim 2 , wherein y is 2 and y′ is 2.
4. The compound of claim 2 , wherein y is 2 and y′ is 3.
5. The compound of claim 2 , wherein y is 2 and y′ is 4.
6. The compound of claim 2 , wherein y is 3 and y′ is 2.
7. The compound of claim 2 , wherein y is 3 and y′ is 3.
8. The compound of claim 2 , wherein y is 3 and y′ is 4.
9. The compound of claim 2 , wherein y is 4 and y′ is 2.
10. The compound of claim 2 , wherein y is 4 and y′ is 3.
11. The compound of claim 2 wherein y is 4 and y′ is 4.