Nutritive Polypeptides and Formulations Thereof, and Methods of Production and Use Thereof

1 .- 62 . (canceled)

63 . A formulation comprising a nutritive polypeptide component consisting essentially of a isolated single chain nutritive polypeptide having an amino acid sequence at least about 90% identical to an edible species polypeptide sequence or fragment thereof at least 50 amino acids in length, wherein the nutritive polypeptide is present in an amount sufficient to provide a nutritional benefit equivalent to or greater than at least about 2% of a reference daily intake value of protein, and wherein the formulation is substantially free of non-comestible products, and wherein the nutritive polypeptide has less than about 50% identity over at least 25 amino acids to a known allergen.

64 . A unit dose comprising an isolated nutritive polypeptide having an amino acid sequence at least about 90% identical to an edible species polypeptide or fragment thereof at least 50 amino acids in length, wherein the nutritive polypeptide is present in the unit dose at a concentration of above about 0.5% by weight, wherein the formulation is substantially free of non-comestible products, and wherein the nutritive polypeptide has less than about 50% identity over at least 25 amino acids to a known allergen.

65 . The unit dose of claim 64 , wherein the nutritive polypeptide is present at a concentration between about 0.5% and about 90% by weight, wherein the formulation is present as a liquid, semi-liquid or gel in a volume not greater than about 500 ml.

66 . The unit dose of claim 64 , wherein the nutritive polypeptide is present at a concentration between about 0.5% and about 99% by weight, wherein the formulation is present as a solid or semi-solid in a total mass not greater than about 200 g.

67 . The formulation of claim 63 , wherein the edible species polypeptide comprises an agriculturally-derived food protein.

68 . The formulation of claim 63 , wherein the nutritive polypeptide is at least about 90% identical to a polypeptide selected from the group consisting of SEQID-40319 to SEQID42840.

69 . The formulation of claim 63 , wherein the edible species polypeptide comprises a nutritional domain of an agriculturally-derived food protein.

70 . The formulation of claim 63 , wherein the edible species polypeptide is a present in a nutritionally substantial quantity in the diet of a human population.

71 . The formulation of claim 63 , wherein the edible species polypeptide is a bovine, ovine, caprine, porcine, piscine, or galline protein.

72 . The formulation of claim 63 , wherein the edible species polypeptide is a leaf vegetable protein.

73 . The formulation of claim 63 , wherein the edible species polypeptide is a seed or fruit protein.

74 . The formulation of claim 63 , wherein the edible species polypeptide is an edible flower or sea vegetable protein.

75 . The formulation of claim 63 , wherein the edible species polypeptide is a legume protein.

76 . The formulation of claim 63 , wherein the edible species polypeptide is a bulb, stem, root, or tuber protein.

77 . The formulation of claim 63 , wherein the edible species polypeptide is a fungal protein.

78 . The formulation of claim 63 , wherein the edible species polypeptide is of microbial origin.

79 . The formulation of claim 63 , wherein the nutritive polypeptide is present in the formulation at a concentration greater than the edible species polypeptid is present in an edible portion of the edible species.

80 . The formulation of claim 63 , wherein the nutritive polypeptide is present in the formulation substantially free of associated proteins.

81 . The formulation of claim 63 , wherein the nutritive polypeptide has a percentage content of one or more branched chain amino acids greater than about 23.67%.

82 . The formulation of claim 63 , wherein the nutritive polypeptide has a percentage content of one or more essential amino acids greater than about 49.04%.

83 . The formulation of claim 63 , wherein the nutritive polypeptide is present in an amount sufficient to provide a healthy adult male human subject with at least about 25% of a reference daily intake value of protein.

84 . The formulation of claim 63 , wherein the nutritive polypeptide is present in an amount sufficient to provide a healthy adult female human subject with at least about 25% of a reference daily intake value of protein.

85 . The formulation of claim 63 , wherein the nutritive polypeptide is present in an amount sufficient to provide a pregnant human subject with at least about 10% of a reference daily intake value of protein.

86 . The formulation of claim 63 , wherein the nutritive polypeptide is produced by a microorganism.

87 . The formulation of claim 63 , wherein the nutritive polypeptide is produced by a microorganism, and wherein the nutritive polypeptide is substantially separated from the microorganism.

88 . The formulation of claim 63 , wherein the nutritive polypeptide is secreted by a microorganism.

89 . The formulation of claim 63 , wherein the nutritive polypeptide is produced by a heterotrophic microorganism.

90 . The formulation of claim 63 , wherein the nutritive polypeptide is produced by a autotrophic microorganism.

91 . The formulation of claim 63 , wherein the nutritive polypeptide is produced by a mixotrophic microorganism.

92 . The formulation of claim 63 , wherein the nutritive polypeptide is produced by a microorganism comprising an exogenous nucleic acid sequence.

93 . The formulation of claim 63 , wherein the nutritive polypeptide comprises an amino acid sequence at least about 90% identical to an edible species polypeptide present in an amount of at least about 1% total protein weight in an edible species, the food species representing at least about 1% of the diet of a human population.

94 . The formulation of claim 63 , wherein the nutritive polypeptide comprises an amino acid sequence at least about 90% identical to an edible species polypeptide present in an amount of at least about 0.1% total weight in a dehydrated food species, the edible species representing at least about 0.1% of the diet of a human population.

95 . The formulation of claim 63 , comprising at least about 5 grams of the nutritive polypeptide.

96 . The formulation of claim 63 , comprising at least one agriculturally-derived carbohydrate and/or lipid.

97 . The formulation of claim 63 , comprising at least one agriculturally-derived protein.

98 . The formulation of claim 63 , further comprising a tastant or flavorant.

99 . The formulation of claim 63 , further comprising a vitamin or mineral.

100 . The formulation of claim 63 , in a liquid, solid, semi-solid, or gel state at room temperature.

101 . The formulation of claim 63 , formulated for administration as an infant formula, an elderly nutritional formula, a prenatal nutrition formula, an athletic performance formula, a ready-to-use therapeutic food formula, or an athletic recovery formula.

102 . The formulation of claim 63 , formulated for administration as a medical food.

103 - 106 . (canceled)

107 . The formulation of claim 63 , wherein an allergenic protein or a polypeptide at least 25% homologous to a known allergen is not substantially present in the formulation.

108 . The formulation of claim 63 , wherein a polypeptide having an allergenic protein or a protein at least 90% identical to an allergenic protein is not substantially present in the formulation.

109 . The formulation of claim 63 , wherein an anti-nutritive polypeptide or a polypeptide comprising an anti-nutritive domain is not substantially present in the formulation.

110 . The formulation of claim 63 , wherein a wheat protein isolated from a wheat grain is not substantially present in the formulation.

111 . The formulation of claim 63 , wherein a soy protein is not substantially present in the formulation.

112 . The formulation of claim 63 , wherein a dairy protein is not substantially present in the formulation.

113 .- 176 . (canceled)