Apparatuses and methods for treating ophthalmic diseases and disorders
The invention relates generally to the fields of biology and health sciences. More particularly, the invention relates to compositions and methods for modulating cellular physiology and pathological processing using a combination of compounds that can be found in amniotic membrane tissue and umbilical cord tissue preparations.
1. An apparatus for treating a disease or disorder of an eye of an individual in need thereof, the apparatus comprising:
(a) an annular tubular structure comprising at least one porous outlet; and wherein the apparatus is configured to reside in a superior conjunctiva fornix, an inferior fornix, or a combination thereof, and to deepen the fornix tear reservoir by stretching the conjunctival sac; and
(b) a therapeutic agent encapsulated by the tubular structure, the therapeutic agent comprising umbilical cord tissue, amniotic membrane tissue, placental tissue, chorion tissue, or a combination thereof.
2. The apparatus of claim 1 , wherein the therapeutic agent comprises amniotic membrane tissue, umbilical cord tissue, or a combination thereof.
3. The apparatus of claim 2 , wherein the therapeutic agent comprises morselized amniotic membrane, or morselized umbilical cord.
4. The apparatus of claim 1 , wherein the annular tubular structure is a tubular structure comprising ethylene vinyl acetate (EVA), polydimethylsiloxane (PDMS), polymethylmetacrylate (PMMA), polyethylene teraphthalate (PET), fibrins, polycarbonate (PC), hydrogels, polyvinyl chloride (PVC), rubber, latex, polyethylene (PE), silicone, polytetrafluoroethylene (PTFE), polyurethane (PU), or a combination thereof.
5. The apparatus of claim 1 , wherein the annular tubular structure has an outside diameter of about 0.5 (centimeters) cm to about 5.0 cm.
6. The apparatus of claim 1 , wherein the annular tubular structure has a cross-sectional diameter of about 0.01 cm to 1 cm.
7. The apparatus of claim 1 , wherein the annular tubular structure has a cross-sectional diameter of about 0.05 cm to 1 cm and an outside diameter of about 2.6 cm to 2.8 cm.
8. The apparatus of claim 1 , wherein the annular tubular structure has a cross-sectional diameter of about 0.1 cm and an outside diameter of about 2.7 cm.
9. The apparatus of claim 1 , wherein the annular tubular structure has at least one porous inlet.
10. The apparatus of claim 1 , wherein the therapeutic agent further comprises an excipient.
11. The apparatus of claim 10 , wherein the excipient comprises a stabilizing agent, a surfactant, a chelating agent, or a combination thereof.
12. A method for treating a disease or disorder of an eye of an individual in need thereof, comprising inserting the apparatus of claim 1 onto the surface of an eye of the individual.
13. The apparatus of claim 1 , wherein the annular tubular structure comprises at least one porous inlet and at least one porous outlet.
14. The apparatus of claim 13 , wherein the at least one porous inlet and the at least one porous outlet form an osmotic pump when in contact with tears in the individual's eye.
15. The apparatus of claim 1 , wherein the annular tubular structure is configured to dissolve when in contact with the tears in the individual's eye.
16. The apparatus of claim 1 , wherein the therapeutic agent is present in a form selected from the group consisting of lyophilized, fresh, sheet, morselized, powder matrix, extract, purified extract, previously frozen, and a suspension.