Pharmaceutical compositions comprising a
Provided herein are pharmaceutical compositions related to a Blautia strain useful as a therapeutic agent.
1. A pharmaceutical composition formulated for oral administration comprising a therapeutically effective amount of a Blautia strain comprising at least 90% genomic, 16S or CRISPR sequence identity to the nucleotide sequence of the Blautia Strain A (ATCC Deposit Number PTA-125346), wherein the pharmaceutical composition is enteric coated.
2. The pharmaceutical composition of claim 1 , wherein at least 50% of the bacteria in the bacterial composition are of the Blautia strain.
3. The pharmaceutical composition of claim 1 , wherein substantially all of the bacteria in the bacterial composition are of the Blautia strain.
4. The pharmaceutical composition of claim 1 , wherein the bacterial composition comprises at least 1×10 6 colony forming units (CFUs) of the Blautia strain.
5. The pharmaceutical composition of claim 1 , wherein the Blautia strain is a strain comprising at least 99% genomic, 16S or CRISPR sequence identity to the nucleotide sequence of the Blautia Strain A (ATCC Deposit Number PTA-125346).
6. The pharmaceutical composition of claim 5 , wherein at least 50% of the bacteria in the bacterial composition are of the Blautia strain.
7. The pharmaceutical composition of claim 5 , wherein substantially all of the bacteria in the bacterial composition are of the Blautia strain.
8. The pharmaceutical composition of claim 5 , wherein the bacterial composition comprises at least 1×10 6 colony forming units (CFUs) of the Blautia strain.
9. The pharmaceutical composition of claim 1 , wherein the Blautia strain is the Blautia Strain A (ATCC Deposit Number PTA-125346).
10. The pharmaceutical composition of claim 9 , wherein at least 50% of the bacteria in the pharmaceutical composition are Blautia Strain A (ATCC Deposit Number PTA-125346).
11. The pharmaceutical composition of claim 9 , wherein substantially all of the bacteria in the pharmaceutical composition are Blautia Strain A (ATCC Deposit Number PTA-125346).
12. The pharmaceutical composition of claim 9 , wherein the pharmaceutical composition comprises at least 1×10 6 colony forming units (CFUs) of Blautia Strain A.
13. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises live bacteria.
14. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises killed bacteria.
15. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is encapsulated.
16. The pharmaceutical composition of claim 1 , further comprising a pharmaceutically acceptable carrier.
17. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is effective for the treatment of an immune disorder.
18. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is effective for the treatment of a metabolic disease.