IP Library › Granted Patent US 12,220,570
Granted Patent B2
US 12,220,570 · App. 16/595,280 · Granted Feb 11, 2025

Intravascular blood pumps and methods of use

Inventors: Daniel Hildebrand (Santa Cruz, CA); Michael Calomeni (San Jose, CA); Brian D. Brandt (Morgan Hill, CA); Janine Robinson (Half Moon Bay, CA); Ari Ryan (San Jose, CA); Daniel Varghai (Scotts Valley, CA); Reza Shirazi (San Jose, CA); Mostafa Ghoreyshi (Campbell, CA); Amr Salahieh (Saratoga, CA)
Assignee: Shifamed Holdings, LLC
A61M60/411A61M60/13A61M60/216A61M60/422A61M60/808A61M60/812A61M60/818A61M60/831A61M60/414
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Quick Facts
Patent No.
US 12,220,570
App. No.
16/595,280
Granted
Feb 11, 2025
Kind
B2
Abstract

Intravascular blood pumps and methods of use. The blood pump include a pump portion that includes a collapsible blood conduit defining a blood flow lumen between an inflow and an outflow. The pump portion includes a distal collapsible impeller axially spaced from a proximal collapsible impeller, at least a portion of each of the distal and proximal collapsible impellers disposed between the inflow and the outflow.

Claims (59)

1. An intravascular blood pump, comprising:

a pump portion that includes:

a collapsible blood conduit and a membrane layer attached to the collapsible blood conduit defining a blood flow lumen between an inflow and an outflow, the collapsible blood conduit comprising one or more struts forming a proximal expandable portion and a distal expandable portion;

a distal collapsible impeller disposed in the distal expandable portion and a proximal collapsible impeller disposed in the proximal expandable portion, the distal collapsible impeller being axially spaced from the proximal collapsible impeller, at least a portion of each of the distal and proximal collapsible impellers disposed between the inflow and the outflow; and

one or more stators in the blood flow lumen, the one or more stators each comprising a plurality of blood flow modifiers secured to the one or more struts and disposed axially between the distal and proximal impellers and being configured to increase a ratio of axial to radial flow of blood flowing through the blood flow lumen.

2. The blood pump of claim 1 , wherein the plurality of blood flow modifiers have radially outer ends that have a configuration shaped to stably interface with a portion of the collapsible blood conduit.

3. The blood pump of claim 2 , wherein the collapsible blood conduit comprises a scaffold having one or more blood flow modifier apertures therethrough, each of the radially outer ends having a configuration shaped to stably interface with one of the blood flow modifier apertures.

4. The blood pump of claim 3 , wherein the membrane layer extends over the scaffold and further secures the one or more blood flow modifiers to the apertures.

5. The blood pump of claim 4 , wherein the apertures are axially extending and parallel to a long axis of the scaffold.

6. The blood pump of claim 3 , wherein the one or more blood flow modifiers are made of a different material than the scaffold material, and one that is more flexible than the scaffold material.

7. The blood pump of claim 6 , wherein the one or more blood flow modifiers are made of a polymeric material.

8. The blood pump of claim 2 , wherein the collapsible blood conduit comprises a self-expanding scaffold, the one or more blood flow modifiers having radially outer ends that have a configuration shaped to stably interface with the self-expanding scaffold.

9. The blood pump of claim 1 , the plurality of blood flow modifiers are positioned closely next to at least one of the proximal impeller and the distal impeller when the proximal and distal impellers and in expanded configurations.

10. The blood pump of claim 9 , wherein the plurality of blood flow modifiers are positioned closely next to the proximal impeller and the distal impeller.

11. The blood pump of claim 9 , wherein the plurality of blood flow modifiers are positioned closely next to the proximal impeller and not the distal impeller.

12. The blood pump of claim 9 , wherein the plurality of blood flow modifiers are positioned closely next to the distal impeller and not the proximal impeller.

13. The blood pump of claim 1 , wherein the plurality of blood flow modifiers are integrally formed with at least a portion of the collapsible blood conduit.

14. The blood pump of claim 13 , wherein the plurality of blood flow modifiers are integral to a scaffold of the collapsible blood conduit.

15. The blood pump of claim 14 , wherein the plurality of blood flow modifiers are biased to a deployed configuration in which they extend radially inward relative to an outer section of the scaffold.

16. The blood pump of claim 1 , wherein the plurality of blood flow modifiers that are secured to and extend radially inward from an outer annular member that does not extend axially all the way from the inflow to the outflow.

17. The blood pump of claim 16 , wherein the outer annular member provides radial support to the collapsible blood conduit.

18. The blood pump of claim 1 , wherein the plurality of blood flow modifiers has an inner free end that is disposed parallel to a longitudinal axis of the pump portion where the flow modifier is disposed.

19. The blood pump of claim 18 , wherein the collapsible blood conduit includes one or more bends formed therein along its length, the one or more bends axially spaced from the one or more blood flow modifiers.

20. The blood pump of claim 1 , wherein the plurality of blood flow modifiers have radially outer sections that are secured to and extend from the collapsible blood conduit along a length of at least 1 mm and not more than 15 cm.

21. The blood pump of claim 20 , wherein the plurality of blood flow modifiers have radially outermost sections that are secured to and extend from the collapsible blood conduit along a length of at least 1 mm and not more than 10 cm, optionally not more than 9 cm, not more than 8 cm, not more than 7 cm, not more than 6 cm, or not more than 5 cm.

22. The blood pump of claim 1 , the plurality of blood flow modifiers being secured to or integral with an annular member that provides radially support for one or more of an impeller basket or scaffold of the blood conduit.

23. The blood pump of claim 22 , wherein the annular member is attached to the blood conduit.

24. The blood pump of claim 1 , wherein the one or more stators are each secured to and extending radially inward from a surface of the collapsible blood conduit.

25. The blood pump of claim 1 , wherein each of the plurality of blood flow modifiers has least one axially extending surface configured to increase pressure between the distal and proximal impellers.

26. The blood pump of claim 1 , wherein the stator does not include a central hub from which a plurality of flow modifying elements extend.

27. The blood pump of claim 1 , wherein the stator includes a central hub from which a plurality of flow modifying elements extend.

28. The blood pump of claim 1 , where the plurality of blood flow modifiers are formed of polymeric material.

29. The blood pump of claim 1 , wherein the plurality of blood flow modifiers are made of a polymeric material.

30. The blood pump of claim 1 , wherein each of the one or more stators comprises at least two blood flow modifiers, optionally four blood flow modifiers.

31. The blood pump of claim 1 , wherein the struts are at a non-orthogonal angle relative to a long axis of the pump portion at the location of the strut.

32. The blood pump of claim 1 , wherein the plurality of blood flow modifiers are integrally formed with at least one other component of the collapsible blood conduit.

33. The blood pump of claim 1 , wherein the plurality of blood flow modifiers have radially outer sections that are secured to and extend from the blood conduit that are longer than radially inner edges of the blood flow modifier.

34. The blood pump of claim 1 , wherein the plurality of blood flow modifiers have a distal end surface and a proximal end surface, at least one of the ends being tapered.

35. The blood pump of claim 1 , wherein the membrane helps secure plurality of blood flow modifiers to the blood conduit.

36. The blood pump of claim 1 , wherein the plurality of blood flow modifiers are adapted to be self-deploying.

37. The blood pump of claim 1 , the plurality of blood flow modifiers each include an axially extending surface that is configured to transition the blood flow towards laminar flow.

38. The blood pump of claim 1 , wherein the plurality of blood flow modifiers are collapsible between an expanded configuration and a collapsed configuration.

39. The blood pump of claim 1 , the plurality of blood flow modifiers are at least one of moveable or reconfigurable between a first position and a deployed position.

40. The blood pump of claim 1 , the plurality of blood flow modifiers that are closer to the proximal impeller than to the distal impeller.

41. The blood pump of claim 1 , the plurality of blood flow modifiers that are closer to the distal impeller than to the proximal impeller.

42. The blood pump of claim 1 , the plurality of blood flow modifiers, wherein a first end of the plurality of blood flow modifiers is 0.01 mm-20 mm from at least one of the distal and proximal impellers.

43. The blood pump of claim 1 , the wherein a first end of the plurality of blood flow modifiers is within 10× luminal diameters of at least one of the distal and proximal impellers.

44. The blood pump of claim 1 , the plurality of blood flow modifiers being part of a collapsible intermediate member positioned and adapted to provide radial support to the blood conduit.

45. The blood pump of claim 1 , the plurality of blood flow modifiers being part of a collapsible intermediate member positioned to maintain tip gap between at least one of the impellers and the blood conduit.

46. The blood pump of claim 1 , the wherein a distal region of the plurality of blood flow modifiers are configured to act as a diffuser to fluid in the fluid conduit to recover pressure from the distal impeller, and wherein a proximal region of the plurality of blood flow modifiers are configured to act as a stator to direct flow towards the proximal impeller.

47. An intravascular blood pump, comprising:

a pump portion that includes:

a collapsible blood conduit defining a blood flow lumen between an inflow and an outflow;

a distal collapsible impeller and a proximal collapsible impeller, the distal collapsible impeller being axially spaced from the proximal collapsible impeller, at least a portion of each of the distal and proximal collapsible impellers disposed between the inflow and the outflow;

one or more proximal struts that define a portion of an expandable basket in which the proximal impeller or distal impeller is disposed;

a membrane layer secured to the expandable basket, the membrane layer at least partially defining the collapsible blood conduit; and

one or more stators in the blood flow lumen each comprising one or more blood flow modifiers, wherein the one or more blood flow modifiers are each secured to one of the one or more struts, the one or more stators disposed axially between the distal and proximal impellers and being configured to increase a ratio of axial to radial flow of blood flowing through the blood flow lumen.

48. The blood pump of claim 47 , wherein the expandable basket is a proximal basket in which the proximal impeller is disposed, the pump portion further comprising a distal expandable basket in which the distal impeller is disposed.

49. The blood pump of claim 47 , wherein the one or more proximal struts are at a non-orthogonal angle relative to a long axis of the pump portion at the location of the one or more proximal struts.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 14, 2025
From: SHIFAMED HOLDINGS, LLC
To: SUPIRA MEDICAL, INC.
Reel/Frame 071338/0442 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 24, 2020
From: HILDEBRAND, DANIEL; CALOMENI, MICHAEL; BRANDT, BRIAN D.; ROBINSON, JANINE; RYAN, ARI; VARGHAI, DANIEL; SHIRAZI, REZA; GHOREYSHI, MOSTAFA; SALAHIEH, AMR
To: SHIFAMED HOLDINGS, LLC
Reel/Frame 053023/0896 →
Continuity (4)
Provisional Application 62741970 · Oct 5, 2018
Provisional Application 62778804 · Dec 12, 2018
Provisional Application 62905818 · Sep 25, 2019
Related Publication 20200246527A1 · Aug 6, 2020
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