Synthesis of cannabigerol

1. A method comprising:

providing a first compound having the structure

combining the first compound with a second compound having the structure:

in a solvent to form a solution;

adding a suitable cross coupling metal catalyst to the solution to form an active mixture; and

reacting the active mixture to form a reacting mixture, wherein the reacting mixture contains a detectable amount of a third compound having the structure:

wherein R 1 and R 3 each are selected from the group consisting of: SEM, MOM, Me, Bn, TBS, and hydrogen;

wherein Z is selected from the group consisting of: boronate group, boronic acid, iodide, and bromide; and

wherein Y is selected from the group consisting of: iodide, bromide, a boronate group, and boronic acid group.

2. The method of claim 1 , wherein the solvent is selected from the group consisting of: N,N-dimethylacetamide, toluene, 1-butanol, tetrahydrofuran, and mixtures thereof.

3. The method of claim 1 , wherein the catalyst is selected from the group consisting of: XPhos-Pd-G3 ((2-Dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate); SPhos-Pd-G2 (Chloro(2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II)); cataCXium-A-Pd-G3 (Mesylate[(di(1-adamantyl)-n-butylphosphine)-2-(2′-amino-1,1′-biphenyl)]palladium(II)); APhos-Pd-G3 ([4-(Di-tert-butylphosphino)-N,N-dimethylaniline-2-(2′-aminobiphenyl)]palladium(II) methanesulfonate); P(Cy)3-Pd-G3 ([(Tricyclohexylphosphine)-2-(2′-aminobiphenyl)]palladium(II) methanesulfonate); PEPPSI-IPent (Dichloro[1,3-bis(2,6-Di-3-pentylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II)); and Pd(PPh3)4 (Palladium-tetrakis(triphenylphosphine)).

4. The method of claim 1 , wherein Y is pinacol boronate.