Combination therapies with EHMT2 inhibitors
The present disclosure relates to a method of preventing or treating a cancer via administering an EHMT2 inhibitor or a combination comprising an EHMT2 inhibitor compound and one or more additional therapeutic agent disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds or combinations for research or other non-therapeutic purposes.
1. A method for treating an acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), or melanoma comprising administering to a subject in need thereof a compound selected from:
or a pharmaceutically acceptable salt thereof,
and one or more additional therapeutic agent selected from a PI3K inhibitor, a MTOR inhibitor, an AKT inhibitor, a BRAF inhibitor, a MEK1 inhibitor, a MEK2 inhibitor, an ERK inhibitor, an EGFR inhibitor, a DNMT inhibitor, a cKIT inhibitor, and a CDK4/6 inhibitor, or any combination thereof.
2. The method of claim 1 , wherein the compound and the one or more additional therapeutic agent are administered simultaneously, sequentially, or in alteration.
3. The method of claim 1 , wherein the one or more additional therapeutic agent is BKM120, GDC-0068, sorafenib, BVD-523, erlotinib, trametinib, selumetinib, pictilisib, MK-2206, everolimus, decitabine, palbociclib, or imatinib, a pharmaceutically acceptable salt thereof, or any combination thereof.
4. A method of inhibiting or decreasing growth, viability, survival, or proliferation of an acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), or melanoma cell comprising (1) contacting the cell with (a) a compound selected from:
or a pharmaceutically acceptable salt thereof,
and (b) one or more additional therapeutic agent selected from a PI3K inhibitor, a MTOR inhibitor, an AKT inhibitor, a BRAF inhibitor, a MEK1 inhibitor, a MEK2 inhibitor, an ERK inhibitor, an EGFR inhibitor, a DNMT inhibitor, a cKIT inhibitor, and a CDK4/6 inhibitor, or any combination thereof.
5. The method of claim 1 , wherein the compound is a selective inhibitor of EHMT2.
6. The method of claim 1 , wherein the one or more additional therapeutic agent is a PI3K inhibitor.
7. The method of claim 1 , wherein the one or more additional therapeutic agent is a MTOR inhibitor.
8. The method of claim 1 , wherein the one or more additional therapeutic agent is an AKT inhibitor.
9. The method of claim 1 , wherein the one or more additional therapeutic agent is a BRAF inhibitor.
10. The method of claim 1 , wherein the one or more additional therapeutic agent is a MEK1 inhibitor or a MEK2 inhibitor.
11. The method of claim 1 , wherein the one or more additional therapeutic agent is an ERK inhibitor.
12. The method of claim 1 , wherein the one or more additional therapeutic agent is an EGFR inhibitor.
13. The method of claim 1 , wherein the one or more additional therapeutic agent is a DNMT inhibitor.
14. The method of claim 1 , wherein the one or more additional therapeutic agent is a cKIT inhibitor.
15. The method of claim 1 , wherein the one or more additional therapeutic agent is a CDK4/6 inhibitor.
16. The method of claim 1 , wherein the one or more additional therapeutic agent is decitabine.
17. The method of claim 1 , wherein the one or more additional therapeutic agent is azacitidine.
18. The method of claim 1 , wherein the one or more additional therapeutic agent is venetoclax.
19. The method of claim 1 , wherein the one or more additional therapeutic agent is ATRA.
20. The method of claim 1 , wherein the one or more additional therapeutic agent is everolimus.