Iodine compositions
The present invention relates to compositions comprising molecular iodine and a vehicle comprising a semifluorinated alkane. The compositions of the invention may be used to treat or prevent diseases or conditions caused by, or associated with microorganisms.
1. A composition consisting of:
a) molecular iodine, and
b) a vehicle;
wherein the vehicle consists of a semifluorinated alkane, and wherein the semifluorinated alkane is of the formula (I):
CF 3 (CF 2 ) n —R m Formula (I)
wherein n is an integer selected from 1 to 12, and R is a linear or branched alkyl or cycloalkyl with m carbon atoms, wherein m is an integer selected from 2 to 12.
2. The composition according to claim 1 , wherein the molecular iodine is dissolved in the vehicle in an amount of up to about 1 mg/mL.
3. The composition according to claim 1 , wherein the composition is free of an iodine species selected from the group consisting of iodide (I − ), triiodide (I 3 − ), iodate (IO 3 − ), hypoiodate (IO − ), and any combination thereof.
4. The composition according to claim 1 , wherein the composition is non-staining and stable at room temperature for at least 30 days.
5. The composition of claim 1 , wherein the semifluorinated alkane is of formula (II):
CF 3 (CF 2 ) n —(CH 2 ) m CH 3 Formula (II)
wherein n and m are each independently selected from an integer from 3 to 10.
6. The composition according to claim 5 , wherein the semifluorinated alkane is selected from the group consisting of CF 3 (CF 2 ) 3 —(CH 2 ) 4 CH 3 (F4H5), CF 3 (CF 2 ) 3 —(CH 2 ) 5 CH 3 (F4H6), CF 3 (CF 2 ) 5 —(CH 2 ) 5 CH 3 (F6H6), CF 3 (CF 2 ) 5 —(CH 2 ) 7 CH 3 (F6H8), CF 3 (CF 2 ) 3 —(CH 2 ) 7 CH 3 (F4H8), CF 3 (CF 2 ) 7 —(CH 2 ) 7 CH 3 (F8H8), and CF 3 (CF 2 ) 9 —(CH 2 ) 4 CH 3 (F10H5).
7. The composition according to claim 5 , wherein the semifluorinated alkane is selected from CF 3 (CF 2 ) 3 —(CH 2 ) 4 CH 3 (F4H5) or CF 3 (CF 2 ) 5 —(CH 2 ) 7 CH 3 (F6H8).
8. The composition according to claim 1 , wherein the composition is formulated as a liquid or as a semi-solid.
9. The composition according to claim 1 , wherein the composition consists of the molecular iodine dissolved in F4H5, F6H2 or F6H8 or a mixture thereof.
10. A kit comprising a composition according to claim 1 , wherein the kit comprises a container adapted for holding and/or storing the composition, and a dispenser adapted for topical administration of the composition to a subject or a surface in need thereof.
11. The composition according to claim 1 , wherein the semifluorinated alkane is of the formula (II):
CF 3 (CF 2 ) n —(CH 2 ) m CH 3 Formula (II)
wherein n is an integer selected from 2 to 9, and m is an integer selected from 1 to 7.
12. The composition according to claim 1 , wherein the semifluorinated alkane is a liquid, semi-solid, or solid at room temperature.
13. The composition according to claim 1 , wherein the composition consists of the molecular iodine dissolved in 1-perfluorohexyl-octane (F6H8) or 1-perfluorobutyl-pentane (F4H5).
14. The composition according to claim 1 , wherein the composition consists of up to about 1.0 mg/mL of the molecular iodine dissolved in a vehicle consisting of 1-perfluorohexyl-octane (F6H8) or 1-perfluorobutyl-pentane (F4H5).
15. The composition according to claim 1 , wherein the semifluorinated alkane is characterized by a boiling point of less than 140° C.
16. The composition according to claim 1 , wherein the composition consists of the molecular iodine dissolved in 1-perfluorobutyl-pentane (F4H5) or 1-perfluorohexyl-ethane (F6H2).
17. The composition according to claim 1 , wherein the composition consists of up to about 0.5 mg/ml of the molecular iodine dissolved in 1-perfluorohexyl-ethane (F6H2).
18. The composition according to claim 1 , wherein the molecular iodine is present in an amount effective to inhibit or prevent the growth or proliferation of a microorganism.
19. The composition according to claim 18 , wherein the microorganism is selected from bacteria, demodex, fungi, or virus.
20. The composition according to claim 1 , wherein the semifluorinated alkane is F6H2.
21. A pharmaceutical composition formulated for topical application to the skin or eye consisting of molecular iodine dissolved in a semifluorinated alkane, wherein the semifluorinated alkane is of the formula (I):
CF 3 (CF 2 ) n —R m Formula (I)
wherein n is an integer selected from 1 to 12, and R is a linear or branched alkyl or cycloalkyl with m carbon atoms, wherein m is an integer selected from 2 to 12.
22. The composition according to claim 21 , wherein the semifluorinated alkane is of formula (II):
CF 3 (CF 2 ) n —(CH 2 ) m CH 3 Formula (II)
wherein n and m are each independently selected from an integer from 3 to 10.
23. The composition according to claim 21 , wherein the semifluorinated alkane is selected from the group consisting of F4H5, F6H2 and F6H8.