IP Library Granted Patent US 11,680,906
Granted Patent B2
US 11,680,906 · App. 16/607,354 · Granted Jun 20, 2023

Sensors having integrated protection circuitry

Inventors: Tracy Helen Fung (San Mateo, CA); Xiuyu Cai (San Diego, CA); Lisa Kwok (San Diego, CA); Hai Tran (San Diego, CA); Kevan Samiee (San Diego, CA); Liangliang Qiang (San Diego, CA); Boyan Boyanov (San Diego, CA)
Assignee: ILLUMINA, INC.
G01N21/6454B01L3/502715G01N15/1436G01N21/6486G01N21/7703G01N2021/7763
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Quick Facts
Patent No.
US 11,680,906
App. No.
16/607,354
Granted
Jun 20, 2023
Kind
B2
Abstract

An example sensor includes a flow cell, a detection device, and a controller. The flow cell includes a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces. The flow cell also includes a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site. The detection device is in contact with a second of the opposed surfaces of the passivation layer, and includes an embedded metal layer that is electrically isolated from other detection circuitry of the detection device. The controller is to ground the embedded metal layer.

Claims (30)

1. A sensor, comprising:

a flow cell, including:

a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces; and

a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site;

a detection device in contact with a second of the opposed surfaces of the passivation layer, the detection device including an embedded metal layer that is electrically isolated from other detection circuitry of the detection device; and

a controller to selectively ground the embedded metal layer.

2. The sensor as defined in claim 1 , wherein the detection device further includes:

an optical sensor electrically connected to the other detection circuitry of the detection device to transmit data signals in response to photons detected by the optical sensor; and

an electrically non-conductive gap between the embedded metal layer and the other detection circuitry.

3. The sensor as defined in claim 2 , further comprising a second controller electrically connecting the optical sensor to the other detection circuitry.

4. The sensor as defined in claim 1 , further comprising a reagent introduced into the flow channel, the reagent having a pH ranging from about 6.5 to about 10 and having a conductivity ranging from about 45 mS/cm to about 85 mS/cm.

5. The sensor of claim 1 , wherein:

the detection device further includes:

an optical waveguide;

an optical sensor operatively associated with the optical waveguide; and

a second embedded metal layer electrically connected to the optical sensor;

wherein the embedded metal layer is spaced from the second embedded metal layer by an electrically isolating gap; and

the sensor further comprises a second controller electrically connecting the second embedded metal layer to the optical sensor to transmit data signals in response to photons detected by the optical sensor.

6. A method, comprising:

introducing a reagent to a flow channel of a sensor that includes:

a flow cell, including:

a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces; and

a lid operatively connected to the passivation layer to partially define the flow channel between the lid and the reaction site;

a detection device in contact with a second of the opposed surfaces of the passivation layer, the detection device including an embedded metal layer that is electrically isolated from other detection circuitry of the detection device;

performing a sensing operation of the sensor in response to a reaction at the reaction site involving at least some reaction component of the reagent; and

during the sensing operation, selectively grounding the embedded metal layer via a controller, thereby providing passive protection to the embedded metal layer.

7. The method as defined in claim 6 , wherein:

the detection device further includes an optical sensor electrically connected to the other device circuitry;

the embedded metal layer is spaced from the other device circuitry that is electrically connected to the optical sensor by an electrically isolating gap; and

the grounding of the embedded metal layer is orthogonal to the sensing operation.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 20, 2019
From: FUNG, TRACY HELEN; CAI, XIUYU; KWOK, LISA; TRAN, HAI; SAMIEE, KEVAN; QIANG, LIANGLIANG; BOYANOV, BOYAN
To: ILLUMINA, INC.
Reel/Frame 051068/0491 →
Priority Claims (1)
NL N2019043 · Jun 9, 2017 · national
Continuity (2)
Provisional Application 62489840 · Apr 25, 2017
Related Publication 20200132605A1 · Apr 30, 2020