CD24
The present invention relates to an in vitro method for determining the risk of occurrence of chronic lung graft dysfunction in a human subject comprising: a) measuring the level of CD9 + B cells in a blood sample of the subject, b) comparing the level of CD9 + B cells measured at step a) with one or more reference values of the level of CD9 + B cells, and c) determining the risk of occurrence of chronic lung graft dysfunction in the said subject from the comparison performed at step b).
1. A method of preventing development of chronic lung graft dysfunction or treating chronic lung graft dysfunction in a lung transplant subject comprising:
a) measuring the level of CD9 + B cells in a blood sample of the lung transplant subject,
and
b) administering a preventive or therapeutic immunosuppressive treatment to the lung transplant subject when the level of CD9 + B cells in the sample is lower than that of a reference value based on lung transplant subjects who did not reject a lung graft; wherein the amount of the immunosuppressive treatment prevents the development of chronic lung graft dysfunction or treats chronic lung graft dysfunction.
2. The method according to claim 1 , wherein step a) is performed with a method further comprising measuring the level of CD24 hi CD38 hi B cells from the blood sample of the lung transplant subject.
3. The method according to claim 2 , wherein step a) is performed with a kit comprising one or more reagents for detecting or quantifying CD9 B cells in the blood sample of the lung transplant subject and further one or both of CD24 and CD38 B cells in the blood sample of the lung transplant subject.
4. The method according to claim 1 , wherein step a) is performed with a kit comprising one or more reagents for detecting or quantifying CD9 B cells in the blood sample of the lung transplant subject.