Methods of manufacturing of niraparib

1. A process for preparing a salt of Formula (7),

said process comprising:

(a) a first process that is preparing a compound of Formula (1), or a salt thereof, comprising:

wherein said first process comprises contacting a compound of Formula (2), or a salt thereof, with a compound of Formula (3), or a salt thereof,

wherein:

R 1 is H or an amine protecting group;

R 2 is H, C 1-10 alkyl, C 1 -10 haloalkyl, or aryl; and

each R 3 is independently H, halogen, C 1 -10 alkyl, C 1 -10 haloalkyl, or aryl;

(b) a second process that is a process for preparing a compound of Formula (5), or a salt thereof,

wherein said second process consists of contacting a compound of Formula (1), or a salt thereof, with a copper salt in the presence of THF and toluene solvents,

and

(c) a third process that is a process for preparing a salt of Formula (7),

wherein A is a cation, wherein said third process comprises contacting a compound of Formula (5), or a salt thereof, with a metal hydroxide,

2. The process of claim 1 , wherein the contacting in said first process is in the presence of an acid that is TFA.

3. The process of claim 1 , wherein R 1 is an amine protecting group that is tert-butyloxycarbonyl group (Boc).

4. The process of claim 1 , wherein the compound of Formula (1) has a structure of Formula (4):

5. The process of claim 1 , wherein the copper salt in said second process is copper(II) trifluoromethanesulfonate (Cu(OTf) 2 ).

6. The process of claim 1 , wherein the salt of Formula (7) has a structure of Formula (8):

7. The process of claim 1 , wherein the compound of Formula (5) has a structure of Formula (6):