Sanfetrinem or a salt or ester thereof for use in treating mycobacterial infection
The present invention relates to or a pharmaceutically acceptable salt or ester prodrug thereof for use in the treatment of a mycobacterial infection or disease resulting from a mycobacterial infection, such as tuberculosis.
1. A method for the treatment of a disease resulting from a mycobacterial infection in a human in need thereof, comprising administering to said human a therapeutically effective amount of a compound which is
or a pharmaceutically acceptable salt thereof.
2. The method according to claim 1 , wherein the disease is tuberculosis.
3. A method for the treatment of a disease resulting from a mycobacterial infection in a human in need thereof, comprising administering to said human a therapeutically effective amount of a compound which is
or a pharmaceutically acceptable salt thereof.
4. The method according to claim 1 , wherein the compound or salt thereof is a sodium salt of compound which is
5. A method of treating tuberculosis in a human in need thereof, comprising administering to said human a composition comprising
(a) the compound which is
or a pharmaceutically acceptable salt or ester prodrug thereof, wherein the ester prodrug is
or a pharmaceutically acceptable salt thereof, and
(b) a pharmaceutically acceptable excipient.
6. A method of treating tuberculosis in a human in need thereof, comprising administering to said human a combination comprising
(a) the compound which is
or a pharmaceutically acceptable salt or ester prodrug thereof, wherein the ester prodrug is
or a pharmaceutically acceptable salt thereof, and
(b) a further anti-tuberculosis agent.
7. The method according to claim 6 , wherein the further anti-tuberculosis agent is selected from isoniazid, rifampin, pyrazinamide, ethambutol, moxifloxacin, rifapentine, clofazimine, ethionamide, prothionamide, isoxyl, thiacetazone, rifabutin, a diarylquinoline such as bedaquiline (TMC207) or TBAJ-587, nitroimidazo-oxazine PA-824, delamanid (OPC-67683), an oxazolidinone, linezolid, tedizolid, radezolid, sutezolid (PNU-100480), posizolid (AZD-5847), TBI-223, EMB analogue SQ109, OPC-167832, GSK3036656 (GSK070), GSK2556286, GSK3211830, a benzothiazinone, BTZ043, PBTZ169, an azaindole, TBA-7371, a dinitrobenzamide, a beta-lactam, meropenem, faropenem, ertapenem, tebipenem, beta-lactam combinations, and AUGMENTIN (amoxicillin-clavulanate).
8. The method according to claim 6 , wherein the further anti-tuberculosis agent is AUGMENTIN (amoxicillin-clavulanate).
9. The method according to claim 6 , further comprising an antiretroviral agent.
10. The method according to claim 9 , wherein the antiretroviral agent is selected from zidovudine, didanosine, lamivudine, zalcitabine, abacavir, stavudine, adefovir, adefovir dipivoxil, fozivudine, todoxil, emtricitabine, alovudine, amdoxovir, elvucitabine, nevirapine, delavirdine, efavirenz, loviride, immunocal, oltipraz, capravirine, lersivirine, GSK2248761, TMC-278, TMC-125, etravirine, saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, fosamprenavir, brecanavir, darunavir, atazanavir, tipranavir, palinavir, lasinavir, enfuvirtide, T-20, T-1249, PRO-542, PRO-140, TNX-355, BMS-806, BMS-663068, BMS-626529, 5-Helix, raltegravir, elvitegravir, GSK1349572, GSK1265744, vicriviroc (Sch-C), Sch-D, TAK779, maraviroc, TAK449, didanosine, tenofovir, lopinavir, and darunavir.
11. A method for the treatment of a disease resulting from a mycobacterial infection in a human in need thereof, comprising administering to said human (a) the compound
or a pharmaceutically acceptable salt or ester prodrug thereof; wherein the ester prodrug is
or a pharmaceutically acceptable salt thereof, and
(b) a β-lactamase inhibitor.
12. The method of claim 11 wherein the disease is tuberculosis.
13. The method of claim 11 wherein the β-lactamase inhibitor is clavulanate or clavulanic acid.
14. The method according to claim 3 , wherein the disease is tuberculosis.