Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of contact lense-related conditions
A pharmaceutical composition comprising a semifluorinated alkane of formula (I): F(CF2) n (CH2) m H, wherein n is an integer from 4 to 6, and m is an integer from 5 to 8, for use in the treatment or prevention of a disease or condition relating to an ocular surface of an eye of an individual, wherein the individual is a contact lens wearer, and wherein the contact lens is a hydro gel contact lens and the composition is administered topically to a surface of the eye of the individual before the contact lens is inserted to the eye of the individual and/or during contact lens wear and/or after the contact lens has been removed from the eye of the individual, or wherein the contact lens is a silicone hydrogel contact lens and the composition is administered topically to a surface of the eye of the individual after the contact lens has been removed from the eye of the individual.
1. A method of treatment or prevention of a disease or condition relating to an ocular surface of an eye of an individual comprising administering a pharmaceutical composition consisting essentially of 1-perfluorohexyl-octane (F6H8) to the ocular surface of the eye of the individual, wherein the individual is a contact lens wearer, and wherein the contact lens is a hydrogel contact lens or a silicone hydrogel contact lens and the composition is administered topically to a surface of the eye of the individual after the contact lens has been removed from the eye of the individual;
wherein the disease or condition related to the ocular surface of an eye of the individual is EOD dryness.
2. The method of claim 1 , wherein the contact lens is a hydrogel contact lens.
3. The method of claim 2 , wherein the hydrogel contact lens comprises a plastic material selected from the of the group consisting of: Acofilcon A; acofilcon B; alphafilcon A; altraficon A; bufilcon A; crofilcon; deltafilcon A; dimefilcon A; droxifilcon A; epsifilcon A; etafilcon A; focofilcon A; hefilcon A & B; hefilcon C; hilafilcon B; hioxifilcon A; hioxifilcon B; hioxifilcon D; isofilcon; lidofilcon A; lidofilcon B; mafilcon; methafilcon A, B; nelfilcon A; nescofilcon A; netrafilcon A; ocufilcon A; ocufilcon B; ocufilcon C; ocufilcon D; ocufilcon E; ocufilcon F; ofilcon A; omafilcon A; perfilcon A; phemfilcon A; phenfilcon A; polymacon; scafilcon A; surfilcon A; tefilcon; tetrafilcon A; tetrafilcon B; vasurfilcon A; vifilcon A; and xylofilcon A.
4. The method of claim 1 , wherein the contact lens is a silicone hydrogel contact lens.
5. The method of claim 4 , wherein the silicon hydrogel contact lens comprises a silicone hydrogel selected from the group of silicone hydrogels consisting of Balafilcon A, comfilcon A, efrofilcon A, enfilcon, galyfilcon A, lotrafilcon A, lotrafilcon B, narafilcon B, senofilcon A, somofilcon A and sifilcon A.
6. The method of claim 1 , wherein the disease or condition related to the ocular surface of an eye of the individual is associated with contact lens wear.
7. The method of claim 1 , wherein the disease or condition related to the ocular surface of an eye of the individual is dryness associated with continued contact lens wear.
8. The method of claim 1 , wherein the disease or condition is characterized by dryness that increases from insertion to removal of the contact lens.
9. A kit comprising a pharmaceutical composition consisting essentially of 1-perfluorohexyl-octane (F6H8), a container for holding said composition, a means for dispensing said composition to the eye of the individual or patient and optionally instructions on how to use and apply said composition when wearing contact lenses.