Dosage regimes for the administration of an anti-CD19 ADC
The present disclosure relates to the treatment of pathological conditions, such as cancer, with Antibody Drug Conjugates (ADCs). In particular, the present disclosure relates to administration of ADCs which bind to CD19 (CD19-ADCS).
1. A method of treating a B-cell lineage non-Hodgkin's Lymphoma in a subject, said method comprising administering to the subject a CD19-antibody drug conjugate (ADC):
wherein the CD19-ADC has the chemical structure:
the Ab is a CD19 antibody comprising a VH domain having the amino acid sequence of SEQ ID NO.2 and a VL domain having the amino acid sequence of SEQ ID NO. 8, and the drug to antibody ratio (DAR) is between 1 and 8;
wherein the CD19-ADC is administered to the subject in a dosage regime comprising multiple treatment cycles and wherein the dose of CD19-ADC is reduced following the second treatment cycle wherein the reduced dose of CD19-ADC is about 50% of the starting dose, and wherein each treatment cycle is 3 weeks.
2. The method according to claim 1 , wherein the starting dose of CD19-ADC is reduced no more than once during the dosage regime.
3. The method according to claim 2 , wherein the starting dose of CD19-ADC is about 60 μg/kg, about 90 μg/kg, about 120 μg/kg, or about 150 μg/kg.
4. The method according to claim 2 , wherein (i) about 150 μg/kg of CD19-ADC are administered for two 3-week treatment cycles, and (ii) 75 μg/kg of CD19-ADC are administered for subsequent 3-week cycles beginning 3 weeks after administration of the second treatment cycle of (i).
5. The method according to claim 1 , wherein the B-cell lineage is non-Hodgkin's Lymphoma, is a non-Hodgkin's Lymphoma selected from diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, (FL), Mantle Cell lymphoma (MCL), chronic lymphatic lymphoma (CLL), Waldenstrom macroglobulinemia, and Marginal Zone B-cell lymphoma (MZBL).
6. The method according to claim 1 , wherein the subject is human.
7. The method according to claim 1 , further comprising administering a chemotherapeutic agent in combination with the CD19-ADC.
8. The method according to claim 7 , wherein the chemotherapeutic agent is ibrutinib.
9. The method according to claim 8 , wherein the ibrutinib is administered in a QD dosage regime at about 560 mg/day.
10. The method according to claim 1 , further comprising administering CD19-ADC to the subject for two additional 3-week treatment cycles.
11. The method according to claim 10 , wherein the additional two CD19-ADC treatment cycles are administered if the subject has not achieved complete response (CR) within 3 months after the completion of the initial two, 3-week treatment cycles.
12. The method according to claim 7 , wherein the chemotherapeutic agent is Durvalumab.
13. The method according to claim 12 , wherein the dose of Durvalumab is about 1500 mg administered in a Q4W dosage regime.
14. The method according to claim 7 , wherein the chemotherapeutic agent is Rituximab.
15. The method according to claim 14 , wherein the Rituximab is administered in a Q3W dosage regime at about 375 mg/m 2 .
16. The method according to claim 1 , wherein the CD19-ADC is administered in combination with a steroid.