IP Library Granted Patent US 11,589,827
Granted Patent B2
US 11,589,827 · App. 16/622,675 · Granted Feb 28, 2023

Nerve activity monitoring

Inventors: Kirill Aristovich (Greater London, GB); David Holder (Greater London, GB); Daniel Chew (Brentford, GB); Matteo Donega (Brentford, GB)
Assignees: UCL Business PLC; Galvani Bioelectronics Limited
A61B5/7246A61B5/1118A61B5/4029A61B5/686A61B5/7228A61B5/742A61N1/36139G16H20/30G16H40/67G16H50/20A61B5/388A61B2560/0475A61N1/0556
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Quick Facts
Patent No.
US 11,589,827
App. No.
16/622,675
Granted
Feb 28, 2023
Kind
B2
Abstract

There is provided a nerve activity monitoring method that includes receiving an input signal indicative of activity in a nerve of a subject; receiving physiological data indicative of physiological activity in the subject; establishing a relationship between the physiological data and the input signal; identifying a plurality of periodic portions in the input signal based on the relationship between the physiological data and the input signal; and outputting the periodic portions identified.

Claims (44)

1. A nerve activity monitoring method comprising:

receiving an input signal indicative of detection of electrical activity in a nerve of a subject;

receiving physiological data indicative of physiological activity in the subject;

establishing a relationship between the physiological data and the input signal;

identifying a plurality of periodic portions in the input signal based on the relationship between the physiological data and the input signal; and

outputting the periodic portions identified by averaging the plurality of periodic portions of the input signal together to generate an averaged signal, wherein averaging the plurality of periodic portions comprises:

calculating a frequency spectrum of at least a portion of the input signal;

identifying a demodulation frequency within the frequency spectrum;

demodulating at least two periodic portions of the input signal based on the demodulation frequency, to generate at least two demodulated signal portions; and

averaging the at least two demodulated signal portions, to generate the averaged signal.

2. The method according to claim 1 , wherein

the physiological data is a physiological signal;

establishing a relationship between the physiological data and the input signal comprises determining a period of periodic portions in the physiological signal, to determine a physiological signal period; and

the plurality of periodic portions in the input signal are identified based on the physiological signal period.

3. The method according to claim 2 , further comprising generating electrical signals for an electrode based on correlation of the identified periodic portions of the input signal with the physiological signal.

4. The method according to claim 1 , further comprising auto-correlating the input signal to identify the periodic portions in the input signal.

5. The method according to claim 1 , wherein calculating a frequency spectrum of at least a portion of the first input signal comprises calculating a frequency spectrum of an individual pulse in the input signal.

6. The method according to claim 5 , wherein identifying a demodulation frequency within the frequency spectrum comprises identifying a frequency peak in the frequency spectrum, wherein the demodulation frequency is the frequency peak.

7. The method according to claim 1 , further comprising outputting the identified periodic portions of the input signal to an external device, wherein the external device is at least one of a display device or a storage module.

8. The method according to claim 1 , wherein the input signal is indicative of activity in an autonomic nerve of a subject.

9. A nerve activity monitoring system comprising:

a communication interface arranged to receive an input signal indicative of detection of electrical activity in a nerve of a subject and arranged to receive physiological data indicative of physiological activity in the subject;

a spectrum module arranged to calculate a frequency spectrum of at least a portion of the input signal;

a frequency identification module arranged to identify a demodulation frequency within the frequency spectrum;

a demodulator module arranged to demodulate at least two periodic portions of the input signal based on the demodulation frequency, to generate at least two demodulated signal portions; and

an averaging module arranged to average the at least two demodulated signal portions, to generate an averaged signal; and

an output module arranged to:

establish a relationship between the physiological data and the input signal;

identify a plurality of periodic portions in the input signal based on the relationship between the physiological data and the input signal; and

output the periodic portions identified by averaging the plurality of periodic portions of the input signal together, to generate an averaged output signal.

10. The system according to claim 9 , wherein the physiological data is a physiological signal, and establishing a relationship between the physiological data and the input signal comprises determining a period of periodic portions in the physiological signal, to determine a physiological signal period;

wherein the plurality of periodic portions in the input signal are identified based on the physiological signal period.

11. The system according to claim 9 , wherein identifying a demodulation frequency within the frequency spectrum comprises identifying a frequency peak in the frequency spectrum, wherein the demodulation frequency is the frequency peak.

12. The system according to claim 9 , further comprising a correlation module arrange to correlate the identified periodic portions of the input signal with the physiological signal, wherein the communication interface is arranged to output electrical signals for an electrode based on the correlation of the identified periodic portions of the input signal with the physiological signal.

13. The system according to claim 9 , wherein the identified periodic portions of the input signal are output to an external device, and wherein the external device is at least one of a display device or a storage module.

14. A nerve activity monitoring system comprising:

a communication interface arranged to receive an input signal indicative of detection of electrical activity in a nerve of a subject and arranged to receive physiological signal indicative of physiological activity in the subject;

a frequency identification module arranged to identify a frequency peak by:

correlating the frequency spectrum with the physiological signal; and

identifying a frequency associated with a frequency peak with the highest correlation with the physiological signal; and

an output module arranged to:

establish a relationship between the physiological signal and the input signal by determining a period of periodic portions in the physiological signal, to determine a physiological signal period;

identify a plurality of periodic portions in the input signal based on the relationship between the physiological signal and the input signal, wherein the plurality of periodic portions in the input signal are identified based on the physiological signal period; and

output the periodic portions identified.

Assignments (3)
CHANGE OF ADDRESS Recorded Apr 16, 2025
From: GALVANI BIOELECTRONICS LIMITED
To: GALVANI BIOELECTRONICS LIMITED
Reel/Frame 070854/0393 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 21, 2022
From: CHEW, DANIEL JOHN; DONEGA, MATTEO
To: GALVANI BIOELECTRONICS LIMITED
Reel/Frame 060266/0701 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 21, 2022
From: ARISTOVICH, KIRILL; HOLDER, DAVID; UNIVERSITY COLLEGE LONDON
To: UCL BUSINESS PLC
Reel/Frame 060266/0755 →
Priority Claims (1)
GB 1709997 · Jun 22, 2017 · national
Continuity (1)
Related Publication 20210137463A1 · May 13, 2021