IP Library Granted Patent US 11,845,922
Granted Patent B2
US 11,845,922 · App. 16/629,415 · Granted Dec 19, 2023

Cell incubator and a tool for use in a cell incubator

Inventor: Alan Blanchard (Middleton, MA)
Assignee: THRIVE BIOSCIENCE, INC.
C12M41/14C12M23/24C12M33/04C12M35/04C12M41/48
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Quick Facts
Patent No.
US 11,845,922
App. No.
16/629,415
Granted
Dec 19, 2023
Kind
B2
Abstract

At least one tool removably mountable on a cell incubator mandrel or a cell incubator having at least one mandrel having an end portion, the at least one mandrel mounted on a movable transport for moving the at least one mandrel and at the least one tool removably mountable on the end portion of the at least one mandrel. The at least one tool is preferably electrically powered and controllable by signals applied to the at least one tool to perform at least one operation with respect to the incubation of cells.

Claims (26)

1. A cell incubator comprising: a housing for holding a culture vessel, at least one mandrel having an end portion, the at least one mandrel mounted on a movable transport for moving the at least one mandrel relative to the culture vessel; and at least one tool removably mountable on the end portion of the at least one mandrel, wherein the at least one tool is electrically powered and controllable by signals applied to the at least one tool to perform at least one operation on cells in or from the culture vessel and wherein the at least one tool includes electrical contacts for mating with contacts on the at least one mandrel for receiving at least one of electrical energy and control signals and an energizable pump receiving at least one of the electrical energy and control signals from the contacts for performing an operation related to the incubation of cells.

2. The cell incubator according to claim 1 , wherein the at least one tool further comprises a battery electrically connected to the energizable pump, said battery being for providing electrical energy to the energizable pump for performing an operation related to the incubation of cells and a control circuit for applying control signals to the energizable pump to control the operation of the energizable pump.

3. The cell incubator according to claim 2 , wherein the at least one tool further comprises a wireless receiver for receiving control signals from externally of the at least one tool.

4. The cell incubator according to claim 1 or claim 2 , wherein the transport moves at least one mandrel in an X-Y plane and moves the at least one mandrel along a Z-axis when a desired position is reached in the X-Y plane.

5. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises a tip having a fluid channel in fluid communication with an inner portion of the at least one tool and on which a pipette is removably mountable.

6. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises a tip engageable with a cell manipulator and wherein the at least one energizeable pump comprises a motor for moving the manipulator when mounted on the tip.

7. The cell incubator according to claim 6 , wherein the cell manipulator is a scraper, a knife or tweezers.

8. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises a reservoir and a tip having a channel in fluid communication with the reservoir and on which a pipette is removably mountable and wherein the energizeable pump outputs an amount of fluid from the reservoir and through the pipette when mounted on the tip.

9. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises a tip having a channel in fluid communication with an internal portion of the at least one tool and on which a pipette is removably mountable and wherein the energizeable pump outputs an amount of fluid through the pipette when mounted on the tip.

10. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises a tip having and on which a cell picker is removably mountable and wherein the energizeable pump comprises a vacuum pump for inputting a cell through the cell picker when mounted on the tip.

11. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises at least one sensor.

12. The cell incubator according to claim 11 , wherein the at least one sensor senses at least one of pH, salts, minerals, temperature, electrical energy, and electromagnetic energy.

13. The cell incubator according to claim 11 , wherein the at least one sensor comprises an optic sensor.

14. The cell incubator according to claim 13 , wherein the optic sensor comprises an imager.

15. The cell incubator according to claim 11 , wherein the at least one sensor comprises an electrical sensor.

16. The cell incubator according to claim 12 , wherein the electrical sensor senses at least capacitively, inductively, or electromagnetically.

17. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises a radiator of plasma energy.

18. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises a radiator of ultrasonic energy.

19. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises a radiator of light.

20. The cell incubator according to claim 19 , wherein the light is fluorescent light.

21. The cell incubator according to claim 19 , wherein the light is ultraviolet light.

22. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises a reservoir and a tip having a channel in fluid communication with the reservoir and on which a pipette is removably mountable and wherein the energizeable a pump outputs a sterilizing gas through the pipette when mounted on the tip.

23. The cell incubator according to claim 1 or claim 2 , wherein the at least one tool further comprises a reservoir for holding a compressed gas and a tip having a channel in fluid communication with the reservoir and on which a pipette is removably mountable and wherein the energizeable pump comprises a valve for permitting the compressed gas to be output through the pipette when mounted on the tip.

24. The cell incubator according to claim 22 , wherein the compressed gas is selected from the group consisting of oxygen, carbon dioxide, nitric oxide, carbon monoxide, hydrogen sulfide, sulfur dioxide, hydrogen cyanide, ammonia, methane, hydrogen, ethylene, and nitrous oxide.

25. The cell incubator according to claim 1 , wherein the at least one tool is removably mounted on the at least one mandrel by one of a friction fit, a screw on connection, a mechanical latch or an electromagnetic connection.

26. The cell incubator according to claim 23 , wherein the compressed gas is selected from the group consisting of oxygen, carbon dioxide, nitric oxide, carbon monoxide, hydrogen sulfide, sulfur dioxide, hydrogen cyanide, ammonia, methane, hydrogen, ethylene, and nitrous oxide.

Assignments (2)
SECURITY INTEREST Recorded Mar 12, 2020
From: THRIVE BIOSCIENCE, INC.
To: EGENDORF, ANDREW
Reel/Frame 052093/0256 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 24, 2020
From: BLANCHARD, ALAN
To: THRIVE BIOSCIENCE, INC.
Reel/Frame 051905/0050 →
Continuity (2)
Provisional Application 62530406 · Jul 10, 2017
Related Publication 20200140803A1 · May 7, 2020