Photosensitive array
The present invention relates to photosensitive arrays comprising a plurality of photosensitive elements disposed in or on a suitable substrate. The photosensitive arrays are useful as implants, in particular as retinal implants. Methods for manufacturing such arrays are also provided.
1. A photosensitive array comprising:
an array of at least two photosensitive elements, each said photosensitive elements comprising at least one pixel array having at least one diode, a stimulating electrode, a counter electrode, and a resistor,
wherein said array comprises at least two photosensitive elements embedded in a biodegradable substrate.
2. The photosensitive array according to claim 1 , wherein each photosensitive element comprises a plurality of pixel arrays.
3. The photosensitive array according to claim 1 , wherein said photosensitive elements are photosensitive chips.
4. The photosensitive array according to claim 1 , wherein a resistance of the resistor is based upon a predetermined relation of resistance, size of the stimulating electrode, and size of the diode.
5. The photosensitive array according to claim 1 , wherein the resistance of the resistor is determined by the formula:
R=a ·( D area {circumflex over (°)}n )· E area
wherein:
R is a resistance of the resistor;
E area is an electrode area;
D area is an effective diode area;
n is an exponent; and
a is a constant.
6. The photosensitive array according to claim 1 , comprising an array of two, three or four photosensitive elements.
7. The photosensitive array according to claim 1 , wherein said at least two photosensitive elements have a substantially elongated, circular, elliptic, triangular, quadrangular, pentagonal, hexagonal, heptagonal or octagonal shape.
8. The photosensitive array according to claim 1 , wherein said array comprises at least two photosensitive elements disposed in or on said substrate at a distance of at least 0.01 mm.
9. The photosensitive array according to claim 1 , wherein said at least two photosensitive elements are disposed in or on the substrate substantially linearly, in a serpentine, circularly, triangularly, quadrangularly, pentagonally, hexagonally, heptagonally, octagonally, in regular or non-regular tiling patterns, honeycomb pattern, grid pattern, filled or non-filled patterns, uniform or non- uniform patterns, or arbitrarily/asymmetrically.
10. The photosensitive array according to claim 1 , further comprising a coating.
11. The photosensitive array according to claim 10 , wherein said coating is contiguous or non-contiguous.
12. The photosensitive array according to claim 10 , wherein at least one of the substrate and the coating consists of a material which is (a) sufficiently flexible to adapt to a shape of a part of a body it is implanted into and (b) sufficiently rigid to prevent folding of the photosensitive implant upon and/or after implantation.
13. The photosensitive array according to claim 10 , wherein at least one of said substrate and said coating is biocompatible.
14. The photosensitive array according to claim 10 , wherein at least one of said substrate and said coating is electrically non-conductive.
15. The photosensitive array according to claim 10 , wherein at least one of said substrate and said coating is configured to allow the stimulating electrodes of the photosensitive elements to stimulate surrounding target cells and/or tissues.
16. The photosensitive array according to claim 10 , wherein said coating is biodegradable.
17. The photosensitive array according to claim 10 comprising a top layer disposed on the photosensitive elements.
18. The photosensitive array according to claim 10 , wherein at least one of said substrate, said coating and a top layer comprises notches or holes.
19. The photosensitive array according to claim 10 , wherein at least one of said substrate, said coating and a top layer comprises at least one active agent selected from an anti-infective agent, an anti-inflammatory agent, a gene-therapy agent and a therapeutic cell.
20. The photosensitive array according to claim 10 , wherein at least one of an upper and lower surface of said substrate and said coating are colored differently.
21. The photosensitive array according to claim 1 , wherein said substrate is configured as a layer supporting the photosensitive elements disposed thereon.
22. The photosensitive array according to claim 21 , wherein said substrate is configured as a film or a membrane.
23. The photosensitive array according to claim 21 , wherein the photosensitive elements extend beyond at least one of the lateral margins of said substrate.
24. The photosensitive array according to claim 21 , wherein said substrate has a length of at least 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, 8 mm, 9 mm or 10 mm, or between 3 mm and 7 mm.
25. The photosensitive array according to claim 21 , wherein said substrate has a width of at least 0.1 mm, 0.2 mm, 0.3 mm, 0.4 mm, 0.5 mm, 0.6 mm, 0.7 mm, 0.8 mm, 0.9 mm, 1.0 mm, 1.1 mm, 1.2 mm, 1.3 mm, 1.4 mm or 1.5 mm, or between 0.5 mm to 1 mm.
26. The photosensitive array according to claim 21 , wherein said substrate has a thickness of between 1 μm and 500 μm.
27. The photosensitive array according to claim 17 , wherein said substrate and/or said top layer comprises material selected from parylene, polyimide, polydimethylsiloxane (PDMS), polyester or a polymer including poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(lactid-co-glycolic acid) (PLGA) or a bioadhesive.
28. The photosensitive array according to claim 1 , wherein said substrate is configured as a capsule enclosing said photosensitive elements.
29. The photosensitive array according to claim 28 , wherein said substrate is a solid, a gel or a viscous fluid.
30. The photosensitive array according to claim 10 , wherein said substrate and/or said coating comprises a material selected from collagen, hyaluronic acid, polyethylenglykol (PEG), poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(lactid-co-glycolic acid) (PLGA), gelatin, hydrogel, or a bioadhesive.
31. The photosensitive array according to claim 28 , wherein said capsule is assembled from at least two different materials.
32. The photosensitive array according to claim 1 , comprising a substrate configured as a layer, and/or a substrate configured as a capsule.
33. The photosensitive array according to claim 1 for use as an implant, or a retinal implant.
34. The photosensitive array according to claim 1 , wherein said substrate is configured as a film or a membrane.
35. The photosensitive array according to claim 34 , wherein said substrate comprises a flexible material, a biocompatible material, an electrically non-conductive material, parylene, polyimide, polydimethylsiloxane (PDMS), polyester a polymer including poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(lactid-co-glycolic acid) (PLGA) or a bioadhesive, or combinations thereof.
36. The photosensitive array according to claim 34 , further comprising a coating .
37. The photosensitive array according to claim 36 , wherein said coating consists of a biodegradable material, a non-biodegradable material, collagen, hyaluronic acid, polyethylenglycol (PEG), poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(lactid-co-glycolic acid) (PLGA), gelatin, a hydrogel adhesive, a biological adhesive, or combinations thereof.
38. The photosensitive array according to claim 1 , wherein said array comprises an array of a plurality of two, three, four or more photosensitive elements, each photosensitive element comprising a plurality of pixel arrays , wherein said elements are disposed in a substrate , and wherein said substrate is configured as a capsule.
39. The photosensitive array according to claim 38 , wherein said substrate comprises a flexible material, a biocompatible material, an electrically non-conductive material, collagen, hyaluronic acid, polyethylenglycol (PEG), poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(lactid-co-glycolic acid) (PLGA), gelatin, a hydrogel adhesive, a biological adhesive, or combinations thereof.
40. A method for producing a photosensitive array according to claim 1 , comprising
(1) providing a substrate;
(2) providing at least two photosensitive elements; and
(3) embedding said photosensitive elements in said substrate.
41. The method of claim 40 , further comprising adding at least one of a coating, a top layer, and a therapeutic agent.