Segmented gastrointestinal devices and methods of use thereof
A gastrointestinal device and methods of use thereof for the treatment of metabolic disorders is provided. The gastrointestinal device features disintegrable sleeve configured to fit within a patient's duodenum and to carry fluid (e.g., liquid or semisolid material, for example, chyme and digestive secretions) from its proximal end to its distal end.
1. A gastrointestinal device comprising a disintegrable sleeve comprising a proximal end and a distal end, the disintegrable sleeve configured to fit within the patient's duodenum and carry fluid from the proximal end to the distal end; wherein the disintegrable sleeve comprises a plurality of non-erodible segments connected by one or more erodible portions; wherein the one or more erodible portions and/or the plurality of non-erodible segments are polygonal; whereupon erosion of the one or more erodible portions, the plurality of non-erodible segments separate.
2. The gastrointestinal device of claim 1 , wherein the plurality of non-erodible segments are aligned along a longitudinal axis.
3. The gastrointestinal device of claim 1 , wherein a shape of the one or more erodible portions and/or the plurality of non-erodible segments varies in a distal-to-proximal direction and the one or more erodible portions are configured to erode in a distal-to-proximal direction.
4. The gastrointestinal device of claim 1 , wherein the one or more erodible portions are strips.
5. The gastrointestinal device of claim 4 , wherein the-strips run substantially non-perpendicularly to the longitudinally aligned non-erodible segments.
6. The gastrointestinal device of claim 1 , wherein the one or more erodible portions have a longitudinal width that is no more than 10% that of the non-erodible segments of the sleeve.
7. The gastrointestinal device of claim 1 , wherein the one or more erodible portions have a thickness that is at least 5% less than the non-erodible segments of the sleeve.
8. The gastrointestinal device of claim 1 , wherein the erodible portions comprise a material selected from the group consisting of poly(lactic acid) (PLA), poly(glycolic acid) (PGA), diolamine, trimethylene carbonate, caprolactone, and copolymers thereof.
9. The gastrointestinal device of claim 8 , wherein the erodible portions comprise PGA.
10. The gastrointestinal device of claim 1 , wherein the non-erodible segments of the sleeve comprises a polymeric material.
11. The gastrointestinal device of claim 10 , wherein the polymeric material is selected from the group consisting of polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), fluorinated ethylene propylene (FEP), perfluoroalkoxy (PFA), ethylene tetrafluoroethylene (EFTE), and polyvinylidene fluoride (PVDF).
12. The gastrointestinal device of claim 11 , wherein the polymeric material comprises PTFE.
13. The gastrointestinal device of claim 1 , further comprising an anchoring system for securing the sleeve to a patient's gastrointestinal tract.
14. The gastrointestinal device of claim 1 , wherein the sleeve contains an eversion-resistant element.
15. The gastrointestinal device of claim 1 , wherein the sleeve is at least 30 cm in length.
16. A method of implanting the gastrointestinal device of claim 1 , the method comprising securing the device to a surface proximal to or within the duodenum of a patient.
17. A method of treating a metabolic disorder, the method comprising implanting in a patient in need thereof the gastrointestinal device of claim 1 , the method comprising securing the device to a surface proximal to or within the duodenum of a patient.
18. The gastrointestinal device of claim 1 , wherein the one or more erodible portions and/or the plurality of non-erodible segments are triangular, hexagonal, rhomboidal, kite-shaped, parallelograms, or a combination thereof.
19. The gastrointestinal device of claim 1 , wherein the one or more erodible portions and/or the plurality of non-erodible segments are diamond-shaped.