Granted Patent B2

US 12,435,188 · App. 16/633,727 · Granted Oct 7, 2025

Inventors: Jin Su Kim (Yongin-si, KR); Wang Soo Shin (Daejeon, KR); Na Jeong Park (Suwon-si, KR)

Assignee: SAMYANG HOLDINGS CORPORATION

C08J3/12A61K9/1647A61K9/1652A61L27/18A61L27/20A61L27/26A61L27/58A61L2300/604C08J2367/04

Abstract

Claims (27)

1. A method for preparing porous biodegradable polymer microparticles, the method comprising the steps of:

1) dissolving a biodegradable polymer and a porogen in an organic solvent to form a dispersed phase;

2) applying pressure to the dispersed phase formed in step 1) to allow the dispersed phase to pass through the pore of SPG membrane (Shirasu Porous Glass membrane), and thereby to form an emulsion in a continuous phase comprising a surfactant; and

3) removing the organic solvent from the emulsion formed in step 2) to form porous microparticles,

wherein the biodegradable polymer is one or more selected from the group consisting of poly(glycolic acid), poly(caprolactone), derivatives thereof and copolymers thereof; and

the porous biodegradable polymer microparticles satisfy the following features i) to iii):

i) spherical shape;

ii) particle diameter of 20 to 40 μm;

iii) porosity ratio of 5 to 50%,

wherein the biodegradable polymer has a number average molecular weight (Mn) in a range of 10,000 to 100,000 g/mol,

wherein the SPG membrane has pores ranging from 10 to 30 μm, and

wherein the porous biodegradable polymer microparticles are suitable for preparing polymer filler for tissue repair.

2. The method for preparing porous biodegradable polymer microparticles according to claim 1 , wherein the porous microparticles satisfy the following feature iv):

iv) pore diameter of 0.1 to 10 μm.

3. The method for preparing porous biodegradable polymer microparticles according to claim 1 , wherein the porous microparticles have d 10 of greater than 20 μm and d 90 of less than 100 μm.

4. The method for preparing porous biodegradable polymer microparticles according to claim 1 , wherein the porous microparticles have a span value of less than 1.

5. The method for preparing porous biodegradable polymer microparticles according to claim 1 , wherein the pressure applied to the dispersed phase is in a range of from 0.1 to 10 kPa.

6. The method for preparing porous biodegradable polymer microparticles according to claim 1 , wherein the surfactant has a concentration in a range of from 0.5 to 5% by weight.

7. The method for preparing porous biodegradable polymer microparticles according to claim 1 , wherein the concentration of biodegradable polymer dissolved in the dispersed phase is in a range of from 5 to 20% by weight.

8. The method for preparing porous biodegradable polymer microparticles according to claim 1 , wherein the continuous phase is agitated at a speed in a range of from 100 to 500 rpm.

9. A method for preparing polymer filler, the method comprising the steps of:

preparing porous biodegradable polymer microparticles by the method according to claim 1 ; and

mixing the porous biodegradable polymer microparticles with one or more biocompatible carriers.

10. A porous biodegradable polymer microparticle prepared by the method according to claim 1 .

11. Polymer filler comprising:

the porous biodegradable polymer microparticle according to claim 10 ; and

one or more biocompatible carriers.

Assignments (2)

Priority Claims (1)

Continuity (1)

References Cited (27)