Systems and methods for temperature-contrast therapy
In one example embodiment, a system for stimulating tissue with the application of temperature-regulated fluid and negative pressure comprises a negative-pressure source adapted to provide negative pressure to a dressing. The system may further comprise a thermoelectric module thermally coupled to a first heat exchange chamber and a second heat exchange chamber and adapted to transfer heat between said heat exchange chambers. The thermoelectric module can be further adapted to maintain a temperature-regulated fluid fluidly coupled to the first heat exchange chamber and the dressing within a predetermined temperature range by adding heat to and extracting heat from the temperature-regulated fluid as it passes through the first heat exchange chamber.
1. A system for stimulating healing of tissue at a tissue site, comprising:
a dressing configured to be positioned at the tissue site;
a source of therapeutic fluid;
a first heat exchange chamber having a fluid inlet fluidly coupled to the source of therapeutic fluid and a fluid outlet fluidly coupled to the dressing;
a second heat exchange chamber having a fluid inlet fluidly coupled to a second fluid source, the second fluid source being substantially the same as the source of therapeutic fluid and a fluid outlet configured to drain into the source of therapeutic fluid; and
a thermoelectric module thermally coupled with the first heat exchange chamber and the second heat exchange chamber, the thermoelectric module adapted to transfer heat between the first heat exchange chamber and the second heat exchange chamber to provide therapeutic fluid from the source of therapeutic fluid alternating between a first temperature and a second temperature.
2. The system of claim 1 , wherein the thermoelectric module comprises a first thermal transfer surface thermally coupled to the first heat exchange chamber and a second thermal transfer surface thermally coupled to the second heat exchange chamber.
3. The system of claim 1 , wherein the thermoelectric module comprises a substantially tubular member, wherein the substantially tubular member has a first thermal transfer surface adapted to be thermally coupled to the first heat exchange chamber and a second thermal transfer surface adapted to be thermally coupled to the second heat exchange chamber.
4. The system of claim 3 , wherein the first thermal transfer surface is an inner surface of the substantially tubular member and the second thermal transfer surface is an outer surface of the substantially tubular member.
5. The system of claim 3 , wherein the first thermal transfer surface is an outer surface of the substantially tubular member and the second thermal transfer surface is an inner surface of the substantially tubular member.
6. The system of claim 1 , wherein the thermoelectric module is configured to transfer heat between the first heat exchange chamber and the second heat exchange chamber in response to an application of power from a DC power source.
7. The system of claim 6 , further comprising a temperature sensor thermally coupled to a fluid path between the dressing and the source of therapeutic fluid, the temperature sensor having an output signal indicative of a temperature at the tissue site.
8. The system of claim 7 , further comprising a controller electrically coupled to the temperature sensor and the thermoelectric module, the controller comprising a temperature controller that compares the output signal to a target temperature, wherein the target temperature includes a hysteresis control band, wherein the controller is configured to maintain the output signal within the hysteresis control band.
9. The system of claim 7 , further comprising a controller electrically coupled to the temperature sensor and the thermoelectric module, the controller comprising a temperature proportional-integral-derivative controller configured for a comparison between the output signal and a target temperature and to vary the power applied to the thermoelectric module based upon the comparison.
10. The system of claim 9 , wherein the controller is configured to periodically cycle the target temperature between the first temperature and the second temperature over a therapeutic time period.
11. The system of claim 10 , wherein the controller is configured to maintain the first temperature and the second temperature for a fixed period of time, wherein the fixed period of time is between 1 and 30 minutes.
12. The system of claim 10 wherein the controller is configured to reduce the temperature at the tissue site if the output signal is greater than the second temperature and increase the temperature at the tissue site if the output signal is less than the first temperature.