Carbamoyl phenylalaninol analogs and uses thereof
The present invention relates to carbamoyl phenylalaninol analogs and methods of using the same to treat disorders.
1. A compound of Formula V:
or a pharmaceutically acceptable salt thereof, wherein:
Z is S;
Y is C═S or SO 2 ;
R is optionally substituted C 1-8 alkyl, halogen, optionally substituted C 1-4 alkoxy, cyano, hydroxy, optionally substituted trifluoromethyl, or C 1-4 thioalkoxy;
n is 0, 1, 2, or 3, with the proviso that R may be the same or different when n is 2 or 3; and
R 1 and R 2 can be the same or different and are independently selected from the group consisting of hydrogen, optionally substituted C 1-8 alkyl, optionally substituted amide, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, and optionally substituted C 3-7 cycloalkyl;
or R 1 and R 2 can be joined to form a 5 to 7-membered heterocycle optionally substituted with alkyl or aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.
2. The compound of claim 1 , having Formula Va:
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , having Formula VIa:
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , which is the hydrochloride salt.
5. A composition comprising the compound of claim 1 .
6. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.
7. The composition of claim 6 , wherein the composition is a dosage form.
8. The composition of claim 7 , wherein the composition is an immediate release oral dosage form.
9. The composition of claim 8 , wherein the composition is a tablet or a capsule.
10. A kit comprising the compound of claim 1 .
11. The compound of claim 1 , wherein R 1 and R 2 are hydrogen.
12. The compound of claim 1 , wherein n is 0.