Carboxamides as ubiquitin-specific protease inhibitors
The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.
1. A compound of Formula (VI)
or a pharmaceutically acceptable salt thereof,
wherein:
X is chosen from C(R)(R″) and O;
each of Y 1 , Y 2 , and Y 3 is independently chosen from C(R 3 ) and N;
R′ is chosen from H, deuterium, and CH 3 ;
each of R and R″ is independently chosen from H, halogens, —OH, —CN, C 1 -C 6 alkyl optionally substituted with one or more Ri, R and R″ together with the carbon they are attached form a spirocyclic cyclopropyl optionally substituted with one or more Ri, wherein any R, R″, or Ri group being or containing hydrogen can independently have one or more hydrogen replaced with deuterium;
each Ri is independently chosen from halogen, —OH, and CH 3 ;
R 1 is chosen from 6-12 membered fused and nonfused heteroaryls optionally substituted with one or more substituent chosen from R 5 and/or R 6 , and further wherein any R 1 group containing hydrogen can have one or more hydrogen replaced with deuterium;
R 2 is chosen from N-linked 4-12 membered heterocyclyls, C-linked 4-12 membered heterocyclyls, and an —O-linked 4-12 membered heterocyclyl, wherein the 4-12 membered heterocyclyls are optionally substituted with one or more R 5 (which can be the same or different from the one or more R 5 of R 1 ), and further wherein any hydrogen in a R 2 group can have one or more hydrogen replaced with deuterium;
each R 3 is independently chosen from H, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, —OH, —CN, (C 3 -C 8 ) cycloalkyl, heterocycloalkyl, aryl, and heteroaryl groups, wherein each of (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl groups are optionally substituted with one or more R 7 ;
R 4 is chosen from H, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, —OH, —CN, (C 3 -C 8 ) cycloalkyl, heterocycloalkyl, aryl, and heteroaryl groups, wherein each of (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, (C 3 -C 8 ) cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more R 5 , and further wherein any R 4 group containing hydrogen can have one or more hydrogen replaced with deuterium;
each R 5 is independently chosen from —OH, —NH 2 , amido-(C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl groups, wherein each of —NH 2 , amido-(C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl are optionally substituted with one or more substituent independently chosen from (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, —NH 2 , and —OH, and wherein any R 5 group containing hydrogen can have one or more hydrogen replaced with deuterium;
each R 6 is independently chosen from -amino alkyl-aryls, -amino alkyl-heteroaryls, -amino alkyl-cyclyl, and -amino alkyl-heterocyclyl groups, wherein each of the R 6 groups are optionally substituted with one or more substituent chosen from —OH, —NH 2 , halogens, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, and (C 1 -C 6 ) haloalkyl groups, and further wherein any R 6 group containing hydrogen can have one or more hydrogen replaced with deuterium;
each R 7 is independently chosen from —OH, —NH 2 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, cycloalkyl, —C(O)-cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl groups, wherein each of —NH 2 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, cycloalkyl, —C(O)-cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl are optionally substituted with one or more substituent independently chosen from (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, and —OH;
and
n is 0, 1, 2, or 3.
2. The compound of claim 1 , of Formula (II):
or a pharmaceutically acceptable salt thereof, wherein
each of X, R 1 , R 2 , R 3 , R 7 and n are as defined in Formula (VI);
R 4 is chosen from H, (C 1 -C 6 ) alkyl, halogen, and —OH;
each R 5 is independently chosen from —OH, —NH 2 , —NHC(O)CH 3 , —C(O)NHCH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl groups, wherein each of —NH 2 , —NHC(O)CH 3 , —C(O)NHCH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl are optionally substituted with one or more substituent independently chosen from (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, —NH 2 , and —OH; and
each R 6 is independently chosen from —NH(C 1 -C 6 )alkyl-aryls, —NH(C 1 -C 6 )alkyl-heteroaryls, —NH(C 1 -C 6 )alkyl-cyclyl, and —NH(C 1 -C 6 )alkyl-heterocyclyl groups, wherein each of the R 6 groups are optionally substituted with one or more substituent chosen from —OH, halogens, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, and (C 1 -C 6 ) haloalkyl groups.
3. The compound of claim 1 , of Formula (IIaa):
or a pharmaceutically acceptable salt thereof, wherein
R 1 is chosen from 8-9-membered heteroaryls substituted with one or more substituent chosen from R 5 and R 6 , wherein each R 5 and R 6 are independently as defined in Formula (II);
R 2 is chosen from N-linked 6-12 membered heterocyclyls or C-linked 6-12 membered heterocyclyls optionally substituted with one or more R 5 , wherein each R 5 is independently chosen from —OH, —NH 2 , —NHC(O)CH 3 , —C(O)NHCH 3 , (C 1 -C 6 )alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halagen, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl groups, wherein each of —NH 2 , —MHC(O)CH 3 , —C(O)NHCH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl are optionally substituted with one or more substituent independently chosen from (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, —NH 2 , and —OH; and
R 3 is independently chosen from H, (C 1 -C 6 ) alkyl, halogen, and —CN, wherein the (C 1 -C 6 ) alkyl groups are optionally substituted with R 7 wherein each R 7 is independently as defined in Formula (VI).
4. The compound of claim 1 , of Formula (IIb′):
or a pharmaceutically acceptable salt thereof, wherein
R′ is chosen from H and CH 3 ;
R 1 is chosen from 8-9 membered heteroaryls substituted with one or more substituent chosen from R 5 and R 6 , wherein each R 5 and/or R 6 (if present) are independently as defined in Formula (VI);
R 2 is chosen from N-linked 6-12 membered heterocyclyls or C-linked 6-12 membered heterocyclyls optionally substituted with one or more R 5 , wherein each R 5 is independently as defined in Formula (VI); and
R 3 is independently chosen from H, (C 1 -C 6 ) alkyl, halogen, and —CN, wherein the (C 1 -C 6 ) alkyl groups are optionally substituted with R 7 wherein each R 7 is independently as defined in Formula (VI).
5. The compound of any one of claims 1 - 4 , wherein R 1 , optionally substituted with R 5 and/or R 6 , is chosen from
6. The compound of any one of claims 1 - 4 , wherein R 2 , optionally substituted with R 5 , is chosen from
7. The compound of any one of claims 1 - 4 , wherein R 1 , optionally substituted with R 5 and/or R 6 , is chosen from
R 2 , optionally substituted with R 5 , is chosen from
8. The compound of any one of claims 1 - 4 , wherein R 1 , optionally substituted with R 5 and/or R 6 , is chosen from
and
R 2 , optionally substituted with R 5 , is chosen from
9. The compound of claim 1 , of Formula (VII):
or a pharmaceutically acceptable sa thereof, wherein
Y is chosen from C(R 3 ) and N;
R′ is chosen from H, deuterium, and CH 3 ;
R 1 is chosen from 6-11 membered heteroaryls optionally substituted with one or more substituent chosen from R 5 and/or R 6 ;
R 2 is chosen from N-linked 4-12 membered heterocyclyls and C-linked 4-12 membered heterocyclyls, wherein the heterocyclyls are optionally substituted with one or more R 5 , and further wherein any R 2 group containing hydrogen can have one or more hydrogen replaced with deuterium;
each R 3 is independently chosen from H, deuterium, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, —OH, —CN, wherein each of (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl groups are optionally substituted with one or more R 7 ;
R 4 is chosen from H, (C 1 -C 6 ) alkyl, halogen, —OH, —CN, and further wherein any R 4 group containing hydrogen can have one or more hydrogen replaced with deuterium;
each R 5 (if present) is independently chosen from —OH, —NH 2 , NHC(O)CH 3 , —C(O)NHCH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl groups, wherein each of —NH 2 , —NHC(O)CH 3 , —C(O)NHCH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl are optionally substituted with one or more substituent independently chosen from (C 1 -C 6 ) alkoxy, —NH 2 , and —OH, and wherein any R 5 group containing hydrogen can have one or more hydrogen replaced with deuterium;
each R 6 (if present) is chosen from —NH(C 1 -C 6 )alkyl-aryls, —NH(C 1 -C 6 ) alkyl-heteroaryls, —NH(C 1 -C 6 )alkyl-heterocyclyl groups, and —NH(C 1 -C 6 ) alkyl-heterocyclyl groups, wherein each of the R 6 groups are optionally substituted with one or more substituent chosen from —OH, —NH 2 , halogens, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, and (C 1 -C 6 ) haloalkyl groups, and further wherein any R 6 group containing hydrogen can have one or more hydrogen replaced with deuterium;
each R 7 is independently chosen from —OH, —NH 2 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, cycloalkyl, —C(O)-cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl groups, wherein each of —NH 2 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, cycloalkyl, —C(O)-cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl are optionally substituted with one or more substituent independently chosen from (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, and —OH;
and
n is 0, 1, 2, or 3.
10. The compound of claim 9 , of Formula (IIIaa):
or a pharmaceutically acceptable salt thereof, wherein
R 1 is chosen from 8-11 membered heteroaryls optionally substituted with one or more R 5 ;
R 2 is chosen from N-linked 4-12 membered heterocyclyls and C-linked 4-12 membered heterocyclyls, optionally substituted with one or more R 5 ;
each R 5 (if present) is independently chosen from —OH, —NH 2 , NHC(O)CH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl groups, wherein each of —NH 2 , —NHC(O)CH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl are optionally substituted with one or more substituent independently chosen from (C 1 -C 6 ) alkoxy, —NH 2 , and —OH; and
n is 0, 1, 2, or 3.
11. The compound of claim 9 , of Formula (VIIaa):
or a pharmaceutically acceptable thereof, wherein
R 1 is chosen from 8-9 membered heteroaryls optionally substituted with one or more R 5 ;
R 2 is chosen from N-linked 4-12 membered heterocyclyls optionally substituted with one or more R 5 ;
each R 5 (if present) is independently chosen from —OH, —NH 2 , NHC(O)CH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl groups, wherein each of —NH 2 , —NHC(O)CH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl are optionally substituted with one or more substituent independently chosen from (C 1 -C 6 ) alkoxy, —NH 2 , and —OH;
and
n is 0, 1, 2, or 3.
12. The compound of any one of claim 10 or 11 , wherein R 1 is chosen from
wherein B is chosen from a bond or C;
Z is chosen from N, S, C(Rii);
Rii is chosen from H, CH 3 and R 5 ;
R 2 is chosen from N-linked 5-8 membered heterocyclyls substituted with one to three R 5 ;
each R 5 (if present) is independently chosen from —OH, —NH 2 , NHC(O)CH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, halogen, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl groups, wherein each of —NH 2 , —NHC(O)CH 3 , (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) haloalkoxy, cycloalkyl, heterocycloalkyl, and —C(O)-heterocycloalkyl are optionally substituted with one or more substituent independently chosen from (C 1 -C 6 ) alkoxy, —NH 2 , and —OH;
and
n is 0, 1, 2, or 3.
13. The compound of any one of claims 9 - 11 wherein
R 1 , optionally substituted with R 5 , is chosen from
and R 2 , optionally substituted with R 5 , is chosen from
14. The compound claim 1 , chosen from any of the following compounds
1-1:
(R)-3-amino-6-methyl-N-(7-(piperazin-1-yl)chroman-3-yl)thieno[2,3-
b]pyridine-2-carboxamide;
1-2:
(S)-3-amino-6-methyl-N-(7-(piperazin-1-yl)chroman-3-yl)thieno[2,3-
b]pyridine-2-carboxamide;
1-3:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-4:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-5:
N-((3R)-7-(3,9-diazabicyclo[3.3.1]nonan-3-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-6:
N-((3S)-7-(3,9-diazabicyclo[3.3.1]nonan-3-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-7:
3-amino-N-((R)-7-((2R,3S)-2,3-dimethylpiperazin-1-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-8:
3-amino-N-((S)-7-((2R,3S)-2,3-dimethylpiperazin-1-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-9:
3-amino-N-((R)-7-((2S,3R)-2,3-dimethylpiperazin-1-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-10:
3-amino-N-((S)-7-((2S,3R)-2,3-dimethylpiperazin-1-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-11:
3-amino-N-((R)-7-((2R,3R)-2,3-dimethylpiperazin-1-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-12:
3-amino-N-((S)-7-((2R,3R)-2,3-dimethylpiperazin-1-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-13:
3-amino-N-((R)-7-((2S,3S)-2,3-dimethylpiperazin-1-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-14:
3-amino-N-((S)-7-((2S,3S)-2,3-dimethylpiperazin-1-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-15:
(R)-3-amino-5-fluoro-6-methyl-N-(7-piperazin-1-yl)chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
1-16:
(S)-3-amino-5-fluoro-6-methyl-N-(7-piperazin-1-yl)chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
1-17:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-3-amino-5-
fluorothieno[2,3-b]pyridine-2-carboxamide;
1-18:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-3-amino-5-
fluorothieno[2,3-b]pyridine-2-carboxamide;
1-19:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-7-amino-3-
methylthieno[2,3-b]pyrazine-6-carboxamide;
1-20:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-7-amino-3-
methylthieno[2,3-b]pyrazine-6-carboxamide;
1-21:
(R)-7-amino-3-methyl-N-(7-(piperazin-1-yl)chroman-3-yl)thieno[2,3-
b]pyrazine-6-carboxamide;
1-22:
(S)-7-amino-3-methyl-N-(7-(piperazin-1-yl)chroman-3-yl)thieno[2,3-
b]pyrazine-6-carboxamide;
1-23:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-6-amino-2-
methylthieno[2,3-d]thiazole-5-carboxamide;
1-24:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-6-amino-2-
methylthieno[2,3-d]thiazole-5-carboxamide;
1-25:
(R)-6-amino-6-methyl-N-(7-(piperazin-1-yl)chroman-3-yl)thieno[2,3-
d]thiazole-5-carboxamide;
1-26:
(S)-6-amino-6-methyl-N-(7-(piperazin-1-yl)chroman-3-yl)thieno[2,3-
d]thiazole-5-carboxamide;
1-27:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-1-ethyl-1H-
pyrrolo[2,3-b]pyridine-5-carboxamide;
1-28:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-1-ethyl-1H-
pyrrolo[2,3-b]pyridine-5-carboxamide;
1-29:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluorochroman-3-yl)-3-
amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
1-30:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluorochroman-3-yl)-3-
amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
1-31:
(R)-3-amino-6-methyl-N-(7-(piperazin-1-yl)-6-
(trifluoromethoxy)chroman-3-yl)thieno[2,3-b]pyridine-2-carboxamide;
1-32:
(S)-3-amino-6-methyl-N-(7-(piperazin-1-yl)-6-
(trifluoromethoxy)chroman-3-yl)thieno[2,3-b]pyridine-2-carboxamide;
1-33:
(R)-3-amino-N-(8-fluoro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-34:
(S)-3-amino-N-(8-fluoro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-35:
(R)-3-amino-N-(6-fluoro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-36:
(S)-3-amino-N-(6-fluoro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
1-37:
(R)-3-amino-N-(5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-2-
methylthieno[2,3-d]thiazole-5-carboxamide;
1-38:
(S)-3-amino-N-(5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-2-
methylthieno[2,3-d]thiazole-5-carboxamide;
1-39:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluorochroman-3-yl)-6-
amino-2-methylthieno[2,3-d]thiazole-5-carboxamide;
1-40:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluorochroman-3-yl)-6-
amino-2-methylthieno[2,3-d]thiazole-5-carboxamide;
1-41:
N-((3S)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-5-fluorochroman-3-yl)-3-
amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
1-42:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-5-fluorochroman-3-yl)-3-
amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
2-1:
3-amino-N-((3R)-7-(9,9-difluoro-3,7-diazabicyclo[3.3.1]nonan-3-
yl)-chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
2-2:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
2-3:
N-((3S)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
2-4:
3-amino-6-methyl-N-((R)-7-((S)-2-methylpiperazin-1-yl)-chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
2-5:
3-amino-6-methyl-N-((R)-7-((R)-2-methylpiperazin-1-yl)-chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
2-6:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-8-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
2-7:
(R)-N-(7-(2,5-diazaspiro[3.4]octan-5-yl)chroman-3-yl)-3-amino-6-
methylthienol[2,3-b]pyridine-2-carboxamide;
2-8:
3-amino-6-methyl-N-((R)-7-((S)-3-methylpiperazin-1-yl)-chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
2-9:
3-amino-6-methyl-N-((R)-7-((R)-3-methylpiperazin-1-yl)-chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
2-10:
(R)-N-(7-(2-oxa-5,8-diazaspiro[3.5]nonan-5-yl)chroman-3-yl)-3-amino-6-
methylthienol[2,3-b]pyridine-2-carboxamide;
2-11:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)chroman-3-yl)-7-amino-3-
methylthieno[2,3-b]pyrazine-6-carboxamide;
2-12:
N-((3R)-7-(3-oxa-7,9-diazabicyclo[3.1.1]nonan-7-yl)chroman-3-yl)-7-
amino-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
2-13:
N-((3R)-7-(9-oxa-3,7-diazabicyclo[3.1.1]nonan-3-yl)chroman-3-yl)-7-
amino-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
2-14:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)chroman-3-yl)-3-amino-6-
fluorothieno[2,3-b]pyridine-2-carboxamide;
2-15:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)chroman-3-yl)-3-amino-5-
fluoro-6-methylthieno[2,3-b]pyridine-2-carboxamide;
2-16:
(R)-3-amino-5-fluoro-6-methoxy-N-(7-(piperazin-1-yl)chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
2-17:
(R)-3-amino-4,6-dimethyl-N-(7-(piperazin-1-yl)chroman-3-yl)thieno[2,3-
b]pyridine-2-carboxamide;
2-18:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)chroman-3-yl)-3-amino-
4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
2-19:
3-amino-N-((3R)-7-(9,9-difluoro-3,7-diazabicyclo[3.3.1]nonan-3-
yl)chroman-3-yl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
2-20:
N-((3R)-7-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)chroman-3-yl)-3-
amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
2-21:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)chroman-3-yl)-3-amino-6-
methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide;
2-22:
3-amino-N-((3R)-7-(9,9-difluoro-3,7-diazabicyclo[3.1.1]nonan-3-
yl)chroman-3-yl)-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-
carboxamide;
2-23:
N-((3R)-7-(9-oxa-3,7-diazabicyclo[3.1.1]nonan-3-yl)chroman-3-yl)-3-
amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide;
2-24:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-2′,3′-dihydro-
1′H-spiro[cyclopropane-1,4′-[1,8]naphthyridine]-6′-carboxamide;
2-25:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-6-
(benzylamino)nicotinamide;
2-26:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)chroman-3-yl)-6-amino-2-
methylthieno[2,3-d]thiazole-5-carboxamide;
2-27:
N-((3R)-7-(3,9-diazabicyclo[3.3.1]nonan-3-yl)chroman-3-yl)-6-amino-2-
methylthieno[2,3-d]thiazole-5-carboxamide;
2-28:
6-amino-N-((3R)-7-(9,9-difluoro-3,7-diazabicyclo[3.3.1]nonan-
3-yl)chroman-3-yl)-2-methylthieno[2,3-d]thiazole-5-carboxamide;
2-29:
N-((3R)-7-(3,9-diazabicyclo[3.3.1]nonan-3-yl)chroman-3-yl)-7-ethyl-7H-
pyrrolo[2,3-c]pyridazine-3-carboxamide;
2-30:
N-((3R)-7-(9,9-difluoro-3,7-diazabicyclo[3.3.1]nonan-3-yl)-chroman-3-yl)-
1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide;
2-31:
(R)-3-amino-N-(8-cyano-5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-4,6-
dimethylthieno[2,3-b]pyridine-2-carboxamide;
2-32:
(R)-3-amino-N-(6-cyano-5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-4,6-
dimethylthieno[2,3-b]pyridine-2-carboxamide;
2-33:
3-amino-N-((3R)-6-cyano-7-(9,9-difluoro-3,7-diazabicyclo[3.3.1]nonan-
3-yl)chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
2-34:
(S)-7-amino-3-methyl-N-(7-methyl-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyrazine-6-carboxamide;
2-35:
(R)-7-amino-3-methyl-N-(7-methyl-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyrazine-6-carboxamide;
2-36:
(S)-7-amino-3-methyl-N-(5-methyl-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyrazine-6-carboxamide;
2-37:
(R)-7-amino-3-methyl-N-(5-methyl-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyrazine-6-carboxamide;
2-38:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-(Á 2 Há,f)methoxypyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
3-1:
3-amino-N-((R)-7-((3S,4S)-3-amino-4-methoxypyrrolidin-1-yl)-chroman-
3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-2:
3-amino-N-((R)-7-((3R,4R)-3-amino-4-methoxypyrrolidin-1-yl)-chroman-
3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-3:
3-amino-N-((R)-7-((S)-3-amino-3-(trifluoromethyl)piperidin-1-
yl)-chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-4:
3-amino-N-((R)-7-((R)-3-amino-3-(trifluoromethyl)piperidin-1-
yl)-chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-5:
3-amino-N-((R)-7-((3R,4S)-3-amino-4-fluoropyrrolidin-1-yl)-chroman-3-
yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-6:
3-amino-N-((R)-7-((3S,4R)-3-amino-4-fluoropyrrolidin-1-yl)-chroman-3-
yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-7:
3-amino-N-((R)-7-((3S,4S)-3-amino-4-fluoropyrrolidin-1-yl)-chroman-3-
yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-8:
3-amino-N-((R)-7-((3S,4R)-3-amino-4-fluoropyrrolidin-1-yl)-chroman-3-
yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-9:
3-amino-N-((R)-7-((3S,4R)-3-amino-4-(trifluoromethoxy)pyrrolidin-1-
yl)-chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-10:
3-amino-N-((R)-7-((3S,4S)-3-amino-4-(trifluoromethoxy)pyrrolidin-1-
yl)-chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-11:
3-amino-6-methyl-N-((R)-7-((R)-3-(trifluoromethyl)piperazin-1-
yl)-chroman-3-yl)thieno[2,3-b]pyridine-2-carboxamide;
3-12:
3-amino-6-methyl-N-((R)-7-((S)-3-(trifluoromethyl)piperazin-1-
yl)-chroman-3-yl)thieno[2,3-b]pyridine-2-carboxamide;
3-13:
N-((R)-7-((S)-2,7-diazaspiro[4.5]decan-2-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
3-14:
N-((R)-7-((R)-2,7-diazaspiro[4.5]decan-2-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
3-15:
(1aS,7bR)-N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-
1a,2,3,7b-tetrahydro-1H-cyclopropa[c][1,8]naphthyridine-6-
carboxamide;
3-16:
(1aR,7bS)-N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-
1a,2,3,7b-tetrahydro-1H-cyclopropa[c][1,8]naphthyridine-6-
carboxamide;
3-17:
3-amino-N-[(3R)-6,8-difluoro-7-(piperazin-1-yl)-3,4-dihydro-2H-1-
benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
3-18:
3-amino-N-[(3S)-6,8-difluoro-7-(piperazin-1-yl)-3,4-dihydro-2H-1-
benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
4-1:
(R)-N-(7-oxa-5,8-diazaspiro[3.5]nonan-8-yl)chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
5-1:
(R)-3-amino-N-(7-(4,4-difluoropiperidin-1-yl))chroman-3-yl)-3-amino-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
5-2:
(R)-3-amino-N-(7-(1,1-dioxidothiomorpholino)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
5-3:
(R)-3-amino-N-(7-(3-hydroxy-3-(trifluoromethyl)azetidin-1-yl)chroman-3-
yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
5-4:
3-amino-N-((3R)-7-(9,9-difluoro-3-oxa-7-azabicyclo[3.3.1]nonan-7-
yl))chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
6-1:
(R)-1-(3-(3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamido)chroman-7-yl)piperidine-4-carboxylic acid;
6-2:
(R)-1-((R)-3-(3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamido)chroman-7-yl)pyrrolidine-3-carboxylic acid;
6-3:
(S)-1-((R)-3-(3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamido)chroman-7-yl)pyrrolidine-3-carboxylic acid;
6-4:
(S)-1-(6-(7-amino-3-methylthieno[2,3-b]pyrazine-6-carboxamido)-
5,6,7,8-tetrahydronaphthalen-2-yl)azetidine-3-carboxylic acid;
7-1:
(R)-3-amino-N-(7-(4-hydroxypiperidin-1-yl))chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
7-2:
3-amino-N-((R)-7-((S)-3-hydroxy-3-methylpiperidin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
7-3:
3-amino-N-((R)-7-((R)-3-hydroxy-3-methylpiperidin-1-yl)chroman-3-yl)-
6-methylthieno[2,3-b]pyridine-2-carboxamide;
7-4:
7-amino-N-((S)-6-((R)-6-hydroxy-1,4-diazepan-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
7-5:
7-amino-N-((R)-6-((R)-6-hydroxy-1,4-diazepan-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
7-6:
7-amino-N-((S)-6-((S)-6-hydroxy-1,4-diazepan-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
7-7:
7-amino-N-((R)-6-((S)-6-hydroxy-1,4-diazepan-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
7-8:
3-amino-N-((S)-6-((S)-3-(hydroxymethyl)piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
7-9:
3-amino-N-((S)-6-((R)-3-(hydroxymethyl)piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
7-10:
3-amino-N-((R)-6-((S)-3-(hydroxymethyl)piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
7-11:
3-amino-N-((R)-6-((R)-3-(hydroxymethyl)piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
8-1:
(R)-3-amino-N-(7-(4-fluoropiperidin-4-yl))chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
9-1:
N-((R)-7-(((S)-5-oxa-2-azaspiro[3.4]octan-7-yl)chroman-3-yl)-3-
amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
9-2:
N-((R)-7-(((R)-5-oxa-2-azaspiro[3.4]octan-7-yl)chroman-3-yl)-3-
amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
10-1:
(R)-3-amino-N-(5-fluoro-7-piperazin-1-yl))chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
10-2:
3-amino-N-((R)-7-((3R,4R)-3-amino-4-methoxypyrrolidin-1-yl)-5-
fluorochroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
10-3:
3-amino-N-((R)-7-((3S,4S)-3-amino-4-methoxypyrrolidin-1-yl)-5-
fluorochroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
10-4:
(R)-3-amino-N-(5-fluoro-7-(piperazin-1-yl-2,2,3,3,5,5,6,6-d8)chroman-3-
yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
10-5:
(S)-3-amino-N-(5-fluoro-7-piperazin-1-yl))chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
10-6:
N-((3R)-7-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-5-fluorochroman-3-
yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
10-7:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-5-fluorochroman-3-yl)-3-
amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
10-8:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-5-fluorochroman-3-yl)-7-
amino-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
10-9:
(R)-3-amino-N-(5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-4,6-
dimethylthieno[2,3-b]pyridine-2-carboxamide;
10-10:
(R)-7-amino-N-(5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-3-
methylthieno[2,3-b]pyrazine-6-carboxamide;
10-11:
(R)-3-amino-N-(5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-6-
methoxythieno[2,3-b]pyridine-2-carboxamide;
10-12:
N-((3R)-7-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-5-fluorochroman-3-
yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
10-13:
N-((3R)-7-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-5-fluorochroman-3-
yl)-3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
10-14:
(R)-3-amino-N-(5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-6-methyl-4-
(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide;
10-15:
3-amino-N-[(3R)-5-fluoro-7-(piperazin-1-yl)-3,4-dihydro-2H-1-
benzopyran-3-yl]-N,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
10-16:
3-amino-N-[(3S)-5-fluoro-7-(piperazin-1-yl)-3,4-dihydro-2H-1-
benzopyran-3-yl]-N,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
11-1:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
11-2:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
11-3:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-5-fluoro-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
11-4:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-5-fluoro-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
11-5:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methoxythieno[2,3-b]pyridine-2-
carboxamide;
11-6:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methoxythieno[2,3-b]pyridine-2-
carboxamide;
11-7:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
11-8:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
11-9:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
11-10:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
11-11:
(S)-3-amino-N-(8-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
11-12:
(R)-3-amino-N-(8-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
11-13:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
11-14:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
11-15:
3-amino-6-methyl-N-((3R,4R)-4-methyl-7-(piperazin-1-yl)chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
11-16:
3-amino-6-methyl-N-((3R,4S)-4-methyl-7-(piperazin-1-yl)chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
11-17:
3-amino-6-methyl-N-((3S,4S)-4-methyl-7-(piperazin-1-yl)chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
11-18:
3-amino-6-methyl-N-((3S,4R)-4-methyl-7-(piperazin-1-yl)chroman-3-
yl)thieno[2,3-b]pyridine-2-carboxamide;
11-19:
(S)-7-amino-3-methyl-N-(6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyrazine-6-carboxamide;
11-20:
(R)-7-amino-3-methyl-N-(6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyrazine-6-carboxamide;
11-21:
(S)-3-amino-6-methyl-N-(6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyridine-2-carboxamide;
11-22:
(R)-3-amino-6-methyl-N-(6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyridine-2-carboxamide;
11-23:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-ethyl-7H-pyrrolo[2,3-c]pyridazine-3-
carboxamide;
11-24:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-ethyl-7H-pyrrolo[2,3-c]pyridazine-3-
carboxamide;
11-25:
7-amino-3-methyl-N-((S)-6-((S)-3-(methylamino)pyrrolidin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyrazine-6-carboxamide;
11-26:
7-amino-3-methyl-N-((R)-6-((S)-3-(methylamino)pyrrolidin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyrazine-6-carboxamide;
11-27:
7-amino-3-methyl-N-((S)-6-((R)-3-(methylamino)pyrrolidin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyrazine-6-carboxamide;
11-28:
7-amino-3-methyl-N-((R)-6-((R)-3-(methylamino)pyrrolidin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-b]pyrazine-6-carboxamide;
11-29:
N-((S)-6-(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
11-30:
N-((R)-6-(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
11-31:
N-((S)-6-(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
11-32:
N-((R)-6-(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
11-33:
(S)-6-amino-2-methyl-N-(6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-d]thiazole-5-carboxamide;
11-34:
(R)-6-amino-2-methyl-N-(6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)thieno[2,3-d]thiazole-5-carboxamide;
11-35:
N-((2S)-6-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
11-36:
N-((2R)-6-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
11-37:
(R)-7-amino-N-(8-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
11-38:
(S)-7-amino-N-(8-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
11-39:
N-((2S)-6-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-8-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
11-40:
N-((2R)-6-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-8-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
12-1:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-amino-2-methylthieno[2,3-d]thiazole-5-
carboxamide;
12-2:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-amino-2-methylthieno[2,3-d]thiazole-5-
carboxamide;
13-1:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5,8-difluorochroman-3-yl)-
3-amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
13-2:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5,8-difluorochroman-3-yl)-
3-amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
13-3:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5,6-difluorochroman-3-yl)-
3-amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
13-4:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5,8-difluorochroman-3-yl)-
3-amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
13-5:
(R)-3-amino-N-(6-chloro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
13-6:
(S)-3-amino-N-(6-chloro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
13-7:
(R)-3-amino-N-(8-chloro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
13-8:
(S)-3-amino-N-(8-chloro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
14-1:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-cyano-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
14-2:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-cyano-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
14-3:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7-cyano-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
14-4:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7-cyano-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
14-5:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-cyano-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
14-6:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-cyano-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
14-7:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7-cyano-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
14-8:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7-cyano-1,2,3,4-
tetrahydronaphthalen-2-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
14-9:
(R)-3-amino-N-(5-cyano-8-fluoro-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
14-10:
(S)-3-amino-N-(5-cyano-8-fluoro-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
14-11:
(R)-7-amino-N-(5-cyano-8-fluoro-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyrazine-6-
carboxamide;
14-12:
(S)-7-amino-N-(5-cyano-8-fluoro-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
14-13:
(R)-6-amino-N-(5-cyano-8-fluoro-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-2-methylthieno[2,3-d]thiazole-5-
carboxamide;
14-14:
(S)-6-amino-N-(5-cyano-8-fluoro-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-2-methylthieno[2,3-d]thiazole-5-
carboxamide;
14-15:
3-amino-N-[(2S)-5-cyano-8-fluoro-6-{9-oxa-3,7-
diazabicyclo[3.3.1]nonan-3-yl}1,2,3,4-tetrahydronaphthalen-2-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
14-16:
3-amino-N-[(2R)-5-cyano-8-fluoro-6-{9-oxa-3,7-
diazabicyclo[3.3.1]nonan-3-yl}1,2,3,4-tetrahydronaphthalen-2-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
14-17:
3-amino-N-[(2S)-5-cyano-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}8-fluoro-
1,2,3,4-tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
14-18:
3-amino-N-[(2R)-5-cyano-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}8-fluoro-
1,2,3,4-tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
14-19:
7-amino-N-[(2S)-5-cyano-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}8-fluoro-
1,2,3,4-tetrahydronaphthalen-2-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
14-20:
7-amino-N-[(2R)-5-cyano-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}8-fluoro-
1,2,3,4-tetrahydronaphthalen-2-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
14-21:
6-amino-N-[(2S)-5-cyano-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}8-fluoro-
1,2,3,4-tetrahydronaphthalen-2-yl]-2-methylthieno[2,3-d][1.3]thiazole-5-
carboxamide;
14-22:
6-amino-N-[(2R)-5-cyano-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}8-fluoro-
1,2,3,4-tetrahydronaphthalen-2-yl]-2-methylthieno[2,3-d][1.3]thiazole-5-
carboxamide;
14-23:
3-amino-N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5-cyano-
8-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
14-24:
3-amino-N-[(2R)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5-cyano-
8-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
15-1:
(R)-3-amino-6-methyl-N-(3-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-7-
yl)thieno[2,3-b]pyridine-2-carboxamide;
15-2:
(S)-3-amino-6-methyl-N-(3-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-7-
yl)thieno[2,3-b]pyridine-2-carboxamide;
16:
(R)-3-amino-6-methyl-N-(7-(piperazin-1-yl)-3,4-dihydro-2H-pyrano[3,2-
c]pyridin-3-yl)thieno[2,3-b]pyridine-2-carboxamide;
17:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluoro-3,4-dihydro-2H-
pyrano[3,2-c]pyridin-3-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
18:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-3,4-dihydro-2H-
pyrano[3,2-c]pyridin-3-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
19:
(R)-3-amino-6-methyl-N-(7-(piperazin-1-yl)-3,4-dihydro-2H-pyrano[2,3-
b]pyridin-3-yl)thieno[2,3-b]pyridine-2-carboxamide;
20:
(R)-3-amino-N-(6-fluoro-7-(piperazin-1-yl)-3,4-dihydro-2H-pyrano[2,3-
b]pyridin-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
21-1:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
21-2:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
21-3:
N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
21-4:
N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
21-5:
(R)-3-amino-N-(5-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
21-6:
(S)-3-amino-N-(5-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
21-7:
(R)-3-amino-N-(7-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
21-8:
(S)-3-amino-N-(7-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
21-9:
(S)-7-amino-N-(5-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
21-10:
(R)-7-amino-N-(5-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
21-11:
(S)-7-amino-N-(7-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
21-12
(R)-7-amino-N-(7-fluoro-6-(piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-
2-yl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
22-1:
(S)-3-amino-N-(5,8-difluoro-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
22-2:
(R)-3-amino-N-(5,8-difluoro-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
22-3:
N-((2S)-6-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-5,8-difluoro-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
22-4:
N-((2R)-6-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-5,8-difluoro-1,2,3,4-
tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
22-5:
3-amino-N-[(2S)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,8-difluoro-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
22-6:
3-amino-N-[(2R)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,8-difluoro-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
23-1:
7-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
23-2:
7-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
23-3:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
23-4:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
23-5:
3-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
23-6:
7-amino-3-methyl-N-[(6S)-2-piperazin-1-yl]-5,6,7,8-tetrahydroquinolin-
6-yl]thieno[2,3-b]pyrazine-6-carboxamide;
23-7:
3-amino-6-methyl-N-[(6S)-2-piperazin-1-yl]-5,6,7,8-tetrahydroquinolin-
6-yl]thieno[2,3-b]pyridine-6-carboxamide;
23-8:
3-amino-6-methyl-N-[(6R)-2-piperazin-1-yl]-5,6,7,8-tetrahydroquinolin-
6-yl]thieno[2,3-b]pyridine-2-carboxamide;
23-9:
6-amino-2-methyl-N-[(6S)-2-piperazin-1-yl]-5,6,7,8-tetrahydroquinolin-
6-yl]thieno[2,3-d]thiazole-5-carboxamide;
23-10:
3-amino-N-[(6S)-2-{3,6-diazabicyclo[3.1.1]heptan-3-yl}-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
23-11:
7-amino-N-[(6S)-2-{3,6-diazabicyclo[3.1.1]heptan-3-yl}-5,6,7,8-
tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
23-12:
3-amino-N-[(6S)-2-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
23-13:
7-amino-N-[(6S)-2-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,6,7,8-
tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
23-14:
3-amino-4,6-dimethyl-N-[(6S)-2-piperazin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
23-15:
3-amino-6-methyl-N-[(6S)-2-[(3S)-3-methylpiperazin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
23-16:
3-amino-6-methyl-N-[(6S)-2-[(3R)-3-methylpiperazin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
23-17:
3-amino-N-[(6S)-4-fluoro-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-
yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
23-18:
3-amino-N-[(6S)-2-{3,8-diazabicyclo[3.2.1]octan-3-yl}4-fluoro-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyrazine-6-carboxamide;
24-1:
3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
24-2:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
25:
3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
26-1:
3-amino-N-[(6S)-2-[(3S,4R)-3-(methoxymethyl)-4-
(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
26-2:
3-amino-N-[(6S)-2-[(3R,4S)-3-(methoxymethyl)-4-
(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
27-1:
3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
27-2:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
28-1:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(2-methoxyethoxy)pyrrolidin-1-
yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
28-2:
3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(2-methoxyethoxy)pyrrolidin-1-
yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
29-1:
3-amino-N-[(6S)-2-[(9S)-9-amino-1,4-dioxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
29-2:
3-amino-N-[(6S)-2-[(9R)-9-amino-1,4-dioxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
30-1:
3-amino-N-[(6S)-3-fluoro-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-
yl]thieno[2,3-b]pyridine-2-carboxamide;
30-2:
3-amino-N-[(6R)-3-fluoro-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-
yl]thieno[2,3-b]pyridine-2-carboxamide;
31-1:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinazolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
31-2:
3-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinazoolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
31-3:
3-amino-6-methyl-N-[(6′S)-2′-(piperazin-1-yl)-6′,7′-dihydro-5′H-
spiro[cyclopropane-1-8′-quinoline]-6′-yl]thieno[2,3-b]pyridine-2-
carboxamide;
31-4:
3-amino-6-methyl-N-[(6′S)-2′-(piperazin-1-yl)-6′,7′-dihydro-5′H-
spiro[cyclopropane-1-8′-quinoline]-6′-yl]thieno[2,3-b]pyridine-2-
carboxamide;
32-1:
3-amino-6-methyl-N-[(7S)-3-(piperazin-1-yl)-5,6,7,8-
tetrahydroisoquinolin-7-yl]thieno[2,3-b]pyridine-2-carboxamide;
32-2:
3-amino-6-methyl-N-[(7R)-3-(piperazin-1-yl)-5,6,7,8-
tetrahydroisoquinolin-7-yl]thieno[2,3-b]pyridine-2-carboxamide;
33-1:
3-amino-N-[(3R)-5-fluoro-7-(piperazin-1-yl)-3,4-dihydro(4,4-Á 2 Há,,)-2H-
1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
33-2:
3-amino-N-[(3S)-5-fluoro-7-(piperazin-1-yl)-3,4-dihydro(4,4-Á 2 Há,,)-2H-
1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
33-3:
3-amino-N-[(3R)-7-{(1R,6S)-3,8-diazabicyclo[4.2.0]octan-8-yl}-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
33-4:
3-amino-N-[(3R)-7-{(1S,6R)-3,8-diazabicyclo[4.2.0]octan-8-yl}-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
34:
3-amino-N-[(3R)-7-(4-cyano-1,1-dioxo-1λ6-thian-4-yl)-3,4-dihydro-2H-1-
benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
35:
3-amino-6-methyl-N-[(3R)-5,6,8-trifluoro-7-(piperazin-1-yl)3,4-dihydro-
2H-1-benzopyran-3-yl]thieno[2,3-b]pyridine-2-carboxamide;
36:
(R)-7-amino-2-ethyl-N-(7-(piperazin-1-yl)chroman-3-yl)-thieno[2,3-
b]pyrazine-6-carboxamide;
37:
(S)-7-amino-2-ethyl-N-(7-(piperazin-1-yl)chroman-3-yl)-thieno[2,3-
b]pyrazine-6-carboxamide;
38:
(R)-1-(difluoromethyl)-N-(7-(piperazin-1-yl)chroman-3-yl)-1H-pyrrolo[2,3-
b]pyridine-5-carboxamide;
39:
(S)-1-(difluoromethyl)-N-(7-(piperazin-1-yl)chroman-3-yl)-1H-pyrrolo[2,3-
b]pyridine-5-carboxamide;
40:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-6-fluorochroman-3-yl)-7-
amino-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
41:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-6-fluorochroman-3-yl)-7-
amino-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
42:
3-amino-N-((S)-7-((3aS,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-
yl)chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
43:
3-amino-N-((R)-7-((3aR,6aR)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-
yl)chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
44:
3-amino-N-((S)-7-((3aR,6aR)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-
yl)chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
45:
(R)-6-amino-2-cyclopropyl-N-(7-(piperazin-1-yl)chroman-3-yl)-thieno[2,3-
d]thiazole-5-carboxamide;
46:
N-((3S)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-6-fluorochroman-3-yl)-6-
amino-2-methylthieno[2,3-d]thiazole-5-carboxamide;
47:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-6-fluorochroman-3-yl)-6-
amino-2-methylthieno[2,3-d]thiazole-5-carboxamide;
48:
(R)-3-amino-N-(5-chloro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
49:
(S)-3-amino-N-(5-chloro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
50:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-5,6,7,8-
tetrahydro-1,8-naphthyridine-3-carboxamide;
51:
N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-3,4-dihydro-
2H-pyrano[2,3-b]pyridine-2-carboxamide;
52:
(R)-6-(benzylamino)-N-(7-(piperazin-1-yl)chroman-3-yl)nicotinamide;
53:
6-(((S)-1-phenylethyl)amino)-N-((R)-7-(piperazin-1-yl)chroman-3-
yl)nicotinamide;
54:
6-(((R)-1-phenylethyl)amino)-N-((R)-7-(piperazin-1-yl)chroman-3-
yl)nicotinamide;
55:
(R)-3-amino-N-(5,8-difluoro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
56:
(R)-6-amino-N-(5,8-difluoro-7-(piperazin-1-yl)chroman-3-yl)-2-
methylthieno[2,3-d]thiazole-5-carboxamide;
57:
(R)-7-hydroxy-N-((R)-7-(piperazin-1-yl)chroman-3-yl)-6,7-dihydro-5H-
cyclopenta[b]pyridine-3-carboxamide;
58:
(S)-7-hydroxy-N-((R)-7-(piperazin-1-yl)chroman-3-yl)-6,7-dihydro-5H-
cyclopenta[b]pyridine-3-carboxamide;
59:
(R)-1-benzyl-N-(7-(piperazin-1-yl)chroman-3-yl)-1H-pyrrolo[2,3-
b]pyridine-5-carboxamide;
60:
(R)-7-amino-N-(8-cyano-5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-3-
methylthieno[2,3-b]pyrazine-6-carboxamide;
61:
(R)-3-amino-N-(5,6-difluoro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
62:
3-amino-N-((R)-7-((3S,4R)-3-hydroxypiperidin-4-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
63:
3-amino-N-((R)-7-((3R,4S)-3-hydroxypiperidin-4-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
64:
3-amino-N-((R)-7-((3R,4R)-3-hydroxypiperidin-4-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
65:
3-amino-N-((R)-7-((3S,4S)-3-hydroxypiperidin-4-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
66:
(R)-6-amino-N-(5,6-difluoro-7-(piperazin-1-yl)chroman-3-yl)-2-
methylthieno[2,3-d]thiazole-5-carboxamide;
67:
(R)-7-amino-N-(6-cyano-5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-3-
methylthieno[2,3-b]pyrazine-6-carboxamide;
68:
(R)-3-amino-N-(5,8-difluoro-7-(piperazin-1-yl)chroman-3-yl)-6-
methylfuro[2,3-b]pyridine-2-carboxamide;
69:
3-amino-N-((R)-7-((R)-3,3-difluoropiperidin-4-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
70:
3-amino-N-((R)-7-((S)-3,3-difluoropiperidin-4-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
71:
(R)-7-amino-3-methyl-N-(7-(piperazin-1-yl)-3,4-dihydro-2H-pyrano[3,2-
c]pyridin-3-yl)thieno[2,3-b]pyrazine-6-carboxamide;
72:
(R)-3-amino-5-fluoro-6-methyl-N-(7-(piperazin-1-yl)-3,4-dihydro-2H-
pyrano[3,2-c]pyridin-3-yl)thieno[2,3-b]pyridine-2-carboxamide;
73:
(7S)-N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-7-
methyl-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carboxamide;
74:
(7R)-N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)chroman-3-yl)-7-
methyl-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carboxamide;
75:
N-((R)-7-((1S,4S)-2,5-diazabicyclo[2.2.2]octan-2-yl)-3,4-dihydro-2H-
pyrano[3,2-c]pyridin-3-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
76:
N-((R)-7-((1R,4R)-2,5-diazabicyclo[2.2.2]octan-2-yl)-3,4-dihydro-2H-
pyrano[3,2-c]pyridin-3-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
77:
N-((3R)-7-(3,6-diazabicyclo[3.1.1]heptan-3-yl)-8-cyano-5-
fluorochroman-3-yl)-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
78:
N-((3R)-7-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-5,8-
difluorochroman-3-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
79:
N-((3R)-7-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-5,6-
difluorochroman-3-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
80:
3-amino-N-((R)-7-((3R,4R)-3-fluoropiperidin-4-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
81:
3-amino-N-((R)-7-((3S,4S)-3-fluoropiperidin-4-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
82:
3-amino-N-((R)-7-((3S,4R)-3-fluoropiperidin-4-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
83:
3-amino-N-((R)-7-((3R,4S)-3-fluoropiperidin-4-yl)chroman-3-yl)-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
84:
N-((R)-5,8-difluoro-7-((3R,4S)-3-hydroxypiperidin-4-yl)chroman-3-yl)-7-
ethyl-7H-pyrrolo[2,3-c]pyridazine-3-carboxamide;
85:
N-((R)-5,8-difluoro-7-((3S,4R)-3-hydroxypiperidin-4-yl)chroman-3-yl)-7-
ethyl-7H-pyrrolo[2,3-c]pyridazine-3-carboxamide;
86:
3-amino-N-((R)-7-((3R,4R)-3-amino-4-methoxypyrrolidin-1-yl)-5,8-
difluorochroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
87:
3-amino-N-((R)-7-((3S,4S)-3-amino-4-methoxypyrrolidin-1-yl)-5,8-
difluorochroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
88:
N-((3R)-7-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)chroman-3-yl)-3-
amino-4-(difluoromethyl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
89:
(1aS,7bR)-N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5,8-
difluorochroman-3-yl)-1a,2,3,7b-tetrahydro-1H-
cyclopropa[c][1,8]naphthyridine-6-carboxamide;
90:
(1aR,7bS)-N-((3R)-7-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5,8-
difluorochroman-3-yl)-1a,2,3,7b-tetrahydro-1H-
cyclopropa[c][1,8]naphthyridine-6-carboxamide;
91:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-methoxypyrrolidin-1-yl]-8-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
92:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-8-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
93:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-methoxypyrrolidin-1-yl]-6-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
94:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-6-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
95:
3-amino-N-[(3R)-8-cyano-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
96:
3-amino-N-[(3R)-8-cyano-5-fluoro-7-{9-oxa-3,7-
diazabicyclo[3.3.1]nonan-3-yl}-3,4-dihydro-2H-1-benzopyran-3-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
97:
7-amino-N-[(3R)-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,6-difluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
98:
6-amino-N-[(3R)-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,8-difluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-2-methylthieno[2,3-d]thiazole-5-
carboxamide;
99:
3-amino-N-[(2S)-5-fluoro-6-{9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl}-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
100:
3-amino-N-[(2R)-5-fluoro-6-{9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl}-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
101:
3-amino-N-[(2S)-7-fluoro-6-{9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl}-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
102:
3-amino-N-[(2S)-5-fluoro-6-{9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl}-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
103:
3-amino-N-[(3R)-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-8-fluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
104:
3-amino-N-[(3R)-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-6-fluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
105:
3-amino-N-[(2R)-8-fluoro-7-{9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl}-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
106:
3-amino-N-[(3R)-6-fluoro-7-{9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl}-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
107:
7-amino-N-[(3R)-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,8-difluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
108:
6-amino-N-[(3R)-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,8-difluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-2-methylthieno[2,3-d]thiazole-5-
carboxamide;
109:
3-amino-N-[(2S)-7-cyano-6-{9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl}-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
110:
3-amino-N-[(3R)-7-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]5,8-
difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
111:
3-amino-N-[(3R)-7-[(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl]5,8-
difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
112:
3-amino-N-[(3R)-7-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]5,6-
difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
113:
3-amino-N-[(3R)-7-{9,9-difluoro-3,7-diazabicyclo[3.3.1]nonan-2-yl}-
2H,3H,4H-pyrano[2,3-b]pyridin-3-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
114:
3-amino-N-[(3R)-7-{9,9-difluoro-3,7-diazabicyclo[3.3.1]nonan-2-yl}-
2H,3H,4H-pyrano[3,2-c]pyridin-3-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
115:
3-amino-N-[(3R)-7-[(1S,4S)-3-amino-4-ethoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
116:
3-amino-N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
117:
7-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
118:
6-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-2-methylthieno[2,3-d]thiazole-5-
carboxamide;
119:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypiperidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
120:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-methoxypiperidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
121:
3-amino-N-[(3R)-7-[(3S,4R)-3-amino-4-methoxypiperidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
122:
3-amino-N-[(3R)-7-[(3R,4S)-3-amino-4-methoxypiperidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
123:
3-amino-6-methyl-N-[(3R)-7-[(1s,4S)-3-aminocyclobutyl]-3,4-dihydro-
2H-1-benzopyran-3-yl]thieno[2,3-b]pyridine-2-carboxamide;
124:
3-amino-6-methyl-N-[(3R)-7-[(1r,3r)-3-aminocyclobutyl]-3,4-dihydro-2H-
1-benzopyran-3-yl]thieno[2,3-b]pyridine-2-carboxamide;
125:
3-amino-6-methyl-N-[(3R)-7-{3-oxa-9-diazabicyclo[3.3.1]nonan-3-yl}-3,4-
dihydro-2H-1-benzopyran-3-yl]thieno[2,3-b]pyridine-2-carboxamide;
126:
3-amino-N-[(3R)-6-cyano-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
127:
3-amino-N-[(3R)-6-cyano-5-fluoro-7-{9-oxa-3,7-
diazabicyclo[3.3.1]nonan-3-yl}-3,4-dihydro-2H-1-benzopyran-3-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
128:
3-amino-N-[(3R)-7-[(3S,4S)-4-amino-3-methoxypiperidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
129:
3-amino-N-[(3R)-7-[(3R,4R)-4-amino-3-methoxypiperidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
130:
7-amino-N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydronaphthalen-2-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
131:
N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydronaphthalen-2-yl]-7-ethyl-7H-pyrrolo[2,3-c]pyridazine-3-
carboxamide;
132:
N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydronaphthalen-2-yl]-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
133:
6-amino-N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydronaphthalen-2-yl]-3-methylthieno[2,3-d][1.3]thiazole-5-
carboxamide;
134:
3-amino-N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydronaphthalen-2-yl]-6-methoxythieno[2,3-b]pyridine-2-
carboxamide;
135:
3-amino-N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydronaphthalen-2-yl]-5-fluoro-6-methoxythieno[2,3-b]pyridine-2-
carboxamide;
136:
3-amino-N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-8-fluoro-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methoxythieno[2,3-b]pyridine-2-
carboxamide;
137:
3-amino-N-[(2R)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-8-fluoro-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methoxythieno[2,3-b]pyridine-2-
carboxamide;
138:
N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-8-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl]-7-ethyl-7H-pyrrolo[2,3-c]pyridazine-3-
carboxamide;
139:
N-[(2R)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-8-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl]-7-ethyl-7H-pyrrolo[2,3-c]pyridazine-3-
carboxamide;
140:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-cyclopropoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
141:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-cyclobutoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
142:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-ethoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
143:
3-amino-N-[(2S)-6-[(3S,4R)-3-amino-4-methoxypyrrolidin-1-yl]1,2,3,4-
tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
144:
3-amino-N-[(2S)-6-[(3R,4S)-3-amino-4-methoxypyrrolidin-1-yl]1,2,3,4-
tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
145:
3-amino-N-[(3R)-7-[(3S,4R)-3-amino-4-methoxypyrrolidin-1-yl]-5-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
146:
3-amino-N-[(3R)-7-[(3R,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
147:
7-amino-N-[(3R)-7-[(3S,4R)-3-amino-4-methoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
148:
7-amino-N-[(3R)-7-[(3R,4S)-3-amino-4-methoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
149:
6-amino-N-[(3R)-7-[(3S,4R)-3-amino-4-methoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-2-methylthieno[2,3-d]thiazole-5-
carboxamide;
150:
6-amino-N-[(3R)-7-[(3R,4S)-3-amino-4-methoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-2-methylthieno[2,3-d]thiazole-5-
carboxamide;
151:
3-amino-N-[(3R)-7-[(3S,4R)-3-amino-4-ethoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
152:
3-amino-N-[(3R)-7-[(3R,4S)-3-amino-4-ethoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
153:
N-[(3R)-7-[(4aS,7aR)-octahydropyrrolo[3,4-b]morpholin-6-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
154:
N-[(3R)-7-[(4aR,7aS)-octahydropyrrolo[3,4-b]morpholin-6-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
155:
3-amino-N-[(3R)-7-[(2S)-2-(methoxymethyl)piperazin-1-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
156:
3-amino-N-[(3R)-7-[(2R)-2-(methoxymethyl)piperazin-1-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
157:
3-amino-N-[(3R)-7-[(3R)-3-(methoxymethyl)piperazin-1-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
158:
3-amino-N-[(3R)-7-[(3S)-3-(methoxymethyl)piperazin-1-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
159:
3-amino-N-[(3R)-5,6-difluoro-7-(piperazin-1-yl)-3,4-dihydro-2H-1-
benzopyran-3-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
160:
3-amino-N-[(3S)-5,6-difluoro-7-(piperazin-1-yl)-3,4-dihydro-2H-1-
benzopyran-3-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
161:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
162:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
163:
3-amino-N-[(3R)-7-[(3S,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
164:
3-amino-N-[(3R)-7-[(3R,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
165:
N-[(3R)-7-[(3aR,6aR)-octahydropyrrolo[2,3-c]pyrrolo-1-yl]-3,4-dihydro-2H-
1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
166:
N-[(3R)-7-[(3aS,6aS)-octahydropyrrolo[2,3-c]pyrrolo-1-yl]-3,4-dihydro-2H-
1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
167:
3-amino-N-[(3R)-7-[(3R,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
168:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
169:
3-amino-N-[(3R)-5-fluoro-7-(piperazin-1-yl)-3,4-dihydro-2H-1-
benzopyran-3-yl]-6-methylfuro[2,3-b]pyridine-2-carboxamide;
170:
3-amino-N-[(3R)-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-fluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylfuro[2,3-b]pyridine-2-
carboxamide;
171:
3-amino-N-[(2S)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-1,2,3,4-
tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
172:
3-amino-N-[(3R)-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,8-difluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylfuro[2,3-b]pyridine-2-
carboxamide;
173:
3-amino-N-[(3R)-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-2H,3H,4H-
pyrano[2,3-b]pyridin-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
174:
7-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-8-cyano-
5-fluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
175:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-8-cyano-
5-fluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
176:
7-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-6-cyano-
3,4-dihydro-2H-1-benzopyran-3-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
177:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-6-cyano-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
178:
3-amino-N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5-cyano-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
179:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-2H,3H,4H-
pyrano[2,3-c]pyridin-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
180:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-ethoxypyrrolidin-1-yl]-2H,3H,4H-
pyrano[2,3-c]pyridin-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
181:
7-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-
2H,3H,4H-pyrano[2,3-b]pyridin-3-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
182:
7-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-ethoxypyrrolidin-1-yl]-2H,3H,4H-
pyrano[2,3-b]pyridin-3-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
183:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-3-fluoro-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
184:
N-[(3R)-7-[(4aR,7aS)-octahydropyrrolo[3,4-b]morpholin-4-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
185:
N-[(3R)-7-[(4aS,7aR)-octahydropyrrolo[3,4-b]morpholin-4-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
186:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
187:
3-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
188:
N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-
naphthyridine-2-carboxamide;
189:
(6aS,7aR)-N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-
naphthyridine-2-carboxamide;
190:
(6aR,7aS)-N-[(2S)-6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-
naphthyridine-2-carboxamide;
191:
(6aS,7aR)-N-[(2S)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-8-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-
naphthyridine-2-carboxamide;
192:
(6aR,7aS)-N-[(2S)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-8-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-
naphthyridine-2-carboxamide;
193:
(6aS,7aR)-N-[(2R)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-8-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-
naphthyridine-2-carboxamide;
194:
(6aR,7aS)-N-[(2R)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-8-fluoro-1,2,3,4-
tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-
naphthyridine-2-carboxamide;
195:
(6aS,7aR)-N-[(2S)-5-cyano-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-8-
fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-
cyclopropa[c]1,8-naphthyridine-2-carboxamide;
196:
(6aR,7aS)-N-[(2S)-5-cyano-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-8-
fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-
cyclopropa[c]1,8-naphthyridine-2-carboxamide;
197:
(6aS,7aR)-N-[(2R)-5-cyano-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-8-
fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-
cyclopropa[c]1,8-naphthyridine-2-carboxamide;
198:
(6aR,7aS)-N-[(2R)-5-cyano-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-8-
fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]5H,6H,6aH,7H,7aH-
cyclopropa[c]1,8-naphthyridine-2-carboxamide;
199:
7-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-6-cyano-
5-fluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-3-methylthieno[2,3-
b]pyrazine-6-carboxamide;
200:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-6-cyano-
5-fluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
201:
3-amino-N-[(2S)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-7-cyano-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
202:
3-amino-N-[(3S)-7-[(3S,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
203:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-5-fluoro-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
204:
3-amino-5-fluoro-6-methyl-N-[(6S)-2-(piperazin-1-yl)-5,6,7,8-
tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
205:
3-amino-6-methyl-N-[(6S,8S)-8-methyl-2-(piperazin-1-yl)-5,6,7,8-
tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
206:
3-amino-6-methyl-N-[(6R,8S)-8-methyl-2-(piperazin-1-yl)-5,6,7,8-
tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
207:
3-amino-6-methyl-N-[(6S,8R)-8-methyl-2-(piperazin-1-yl)-5,6,7,8-
tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
208:
3-amino-6-methyl-N-[(6R,8R)-8-methyl-2-(piperazin-1-yl)-5,6,7,8-
tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
209:
3-amino-6-methyl-N-[(3R)-7-{3-oxa-7,9-diazabicyclo[3.3.1]nonan-9-yl}-
3,4-dihydro-2H-1-benzopyran-3-yl]thieno[2,3-b]pyridine-2-carboxamide;
210:
3-amino-N-[(6S)-2-[(3S,4S)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
211:
3-amino-N-[(6S)-2-[(3R,4R)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
212:
3-amino-N-[(3R)-7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
213:
3-amino-N-[(3R)-7-[(3S,4S)-3-acetamido-4-methoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
214:
3-amino-N-[(3R)-7-[(4R)-4-amino-3,3-dimethylpyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
215:
3-amino-N-[(3R)-7-[(4S)-4-amino-3,3-dimethylpyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
216:
N-[(6S)-2-[(3aS,6aS)-octahydropyrrolo[2,3-c]pyrrol-1-yl]5,6,7,8-
tetrahydroquinolin-6-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
217:
N-[(6S)-2-[(3aR,6aR)-octahydropyrrolo[2,3-c]pyrrol-1-yl]5,6,7,8-
tetrahydroquinolin-6-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
218:
N-[(6S)-2-[(3aS,6aS)-octahydropyrrolo[2,3-c]pyrrol-1-yl]5,6,7,8-
tetrahydroquinolin-6-yl]-3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
219:
N-[(6S)-2-[(3aR,6aR)-octahydropyrrolo[2,3-c]pyrrol-1-yl]5,6,7,8-
tetrahydroquinolin-6-yl]-3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
220:
N-[(3R)-7-[(3aS,6aS)-octahydropyrrolo[2,3-c]pyrrol-1-yl]-5-fluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
221:
N-[(3R)-7-[(3aR,6aR)-octahydropyrrolo[2,3-c]pyrrol-1-yl]-5-fluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
222:
N-[(3R)-7-[(3aS,6aS)-octahydropyrrolo[2,3-c]pyrrol-1-yl]-5-fluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-4,6-dimethylthieno[2,3-
b]pyridine-2-carboxamide;
223:
N-[(3R)-7-[(3aR,6aR)-octahydropyrrolo[2,3-c]pyrrol-1-yl]-5-fluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-4,6-dimethylthieno[2,3-
b]pyridine-2-carboxamide;
224:
N-[(3R)-7-[(3aR,7aR)-octahydro-1H-pyrrolo[2,3-c]pyridin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
225:
N-[(3R)-7-[(3aS,7aR)-octahydro-1H-pyrrolo[2,3-c]pyridin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
226:
N-[(3R)-7-[(3aS,6aS)-octahydropyrrolo[2,3-c]pyrrol-1-yl]-3,4-dihydro-2H-
1-benzopyran-3-yl]-3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
227:
N-[(3R)-7-[(3aR,6aR)-octahydropyrrolo[2,3-c]pyrrol-1-yl]-3,4-dihydro-2H-
1-benzopyran-3-yl]-3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
228:
(6aS,7aR)-N-[(3R)-8-cyano-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-
fluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-5H,6H,6aH,7H,7aH-
cyclopropa[c]1,8-naphthyridine-2-carboxamide;
229:
(6aR,7aS)-N-[(3R)-8-cyano-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-
fluoro-3,4-dihydro-2H-1-benzopyran-7-3-yl]-5H,6H,6aH,7H,7aH-
cyclopropa[c]1,8-naphthyridine-2-carboxamide;
230:
3-amino-N-[(3R)-8-cyano-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
231:
N-[(3R)-7-[(3aR,6R,7aR)-6-amino-octahydro-1H-indol-1-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
232:
N-[(3R)-7-[(3aR,6S,7aR)-6-amino-octahydro-1H-indol-1-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
233:
N-[(3R)-7-[(3aS,6R,7aS)-6-amino-octahydro-1H-indol-1-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
234:
N-[(3R)-7-[(3aS,6S,7aS)-6-amino-octahydro-1H-indol-1-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
235:
N-[(3R)-7-[(3aS,7aR)-octahydro-1H-pyrrolo[3,2-c]pyridin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
236:
N-[(3R)-7-[(3aR,7aS)-octahydro-1H-pyrrolo[3,2-c]pyridin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
237:
N-[(3R)-7-[(4aR,7aR)-4,4-difluoro-octahydro-1H-pyrrolo[3,4-b]pyridin-6-
yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
238:
N-[(3R)-7-[(4aS,7aS)-4,4-difluoro-octahydro-1H-pyrrolo[3,4-b]pyridin-6-
yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
239:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxy-3-methylpyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
240:
3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-methoxy-3-methylpyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
241:
3-amino-N-[(3R)-6-cyano-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
242:
N-[(3R)-7-[(4aR,7aR)-octahydro-1H-pyrrolo[3,4-c]pyridin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
243:
N-[(3R)-7-[(4aS,7aS)-octahydro-1H-pyrrolo[3,4-c]pyridin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
244:
3-amino-N-[(3R)-7-[(2R,5R)-5-amino-2-(trifluoromethyl)piperidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
245:
3-amino-N-[(3R)-7-[(2S,5S)-5-amino-2-(trifluoromethyl)piperidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
246:
3-amino-N-[(3R)-7-[(2R,5S)-5-amino-2-(trifluoromethyl)piperidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
247:
3-amino-N-[(3R)-7-[(2S,5R)-5-amino-2-(trifluoromethyl)piperidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
248:
N-[(3R)-7-[(3aS)-3a-amino-octahydrocyclopenta[c]pyrrol-2-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
249:
N-[(3R)-7-[(3aR)-3a-amino-octahydrocyclopenta[c]pyrrol-2-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
250:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5-fluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
251:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5-fluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
252:
3-amino-N-[(2S)-6-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
253:
3-amino-N-[(2S)-6-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
254:
3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-ethoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
255:
3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-ethoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
256:
3-amino-N-[(3R)-7-[(4S)-4-amino-3,3-difluoropyrrolidin-1-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
257:
3-amino-N-[(3R)-7-[(4R)-4-amino-3,3-difluoropyrrolidin-1-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
258:
3-amino-N-[(3R)-7-[(8R)-8-amino-2-oxa-6-azaspiro[3.4]octan-6-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
259:
3-amino-N-[(3R)-7-[(8S)-8-amino-2-oxa-6-azaspiro[3.4]octan-6-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
260:
3-amino-N-[(3R)-7-[(2S,4R)-4-amino-2-(methoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
261:
3-amino-N-[(3R)-7-[(2R,4S)-4-amino-2-(methoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
262:
3-amino-N-[(3R)-7-[(2R,4R)-4-amino-2-(methoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
263:
3-amino-N-[(3R)-7-[(2S,4S)-4-amino-2-(methoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
264:
(6aS,7aR)-N-[(3R)-6-cyano-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-
fluoro-3,4-dihydro-2H-1-benzopyran-7-3-yl]-5H,6H,6aH,7H,7aH-
cyclopropa[c]1,8-naphthyridine-2-carboxamide;
265:
(6aR,7aS)-N-[(3R)-6-cyano-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-
fluoro-3,4-dihydro-2H-1-benzopyran-7-3-yl]-5H,6H,6aH,7H,7aH-
cyclopropa[c]1,8-naphthyridine-2-carboxamide;
266:
7-amino-N-[(6S)-2-[(3S,4S)-3-acetamido-4-methoxypyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
267:
3-amino-N-[(2S)-6-[(3S,4R)-3-amino-4-ethoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydrophthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
268:
3-amino-N-[(2S)-6-[(3R,4S)-3-amino-4-ethoxypyrrolidin-1-yl]-1,2,3,4-
tetrahydrophthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
269:
3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
270:
3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
271:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinazolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
272:
3-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinazolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
273:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinazolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
274:
3-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinazolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
275:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
276:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
277:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-4,6-dimethylthieno[2,3-
b]pyridine-2-carboxamide;
278:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-4,6-dimethylthieno[2,3-
b]pyridine-2-carboxamide;
279:
7-amino-N-[(6S)-2-[(3S,4S)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
280:
7-amino-N-[(6S)-2-[(3R,4R)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
281:
3-amino-N-[(3R)-7-[(3S,4S)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
282:
3-amino-N-[(3R)-7-[(3R,4R)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
283:
3-amino-N-[(3R)-7-[(2S,3R,4S)-4-amino-3-methoxy-2-methylpyrrolidin-
1-yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
284:
3-amino-N-[(3R)-7-[(2R,3S,4R)-4-amino-3-methoxy-2-methylpyrrolidin-
1-yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
285:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-cyclobutoxypyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
286:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-
2H,3H,4H-pyrano[2,3-b]pyridin-3-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
287:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-
2H,3H,4H-pyrano[2,3-b]pyridin-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
288:
3-amino-N-[(3R)-7-[(3R)-3-amino-pyrrolidin-1-yl]-3,4-dihydro-2H-1-
benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
289:
N-[(3R)-7-[(3aR,6aS)-3a-methoxy-octahydropyrrolo[2,3-c]pyrrol-5-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
290:
N-[(3R)-7-[(3aS,6aR)-3a-methoxy-octahydropyrrolo[2,3-c]pyrrol-5-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
291:
N-[(3R)-7-[(3aS,6aS)-3a-methoxy-octahydropyrrolo[2,3-c]pyrrol-2-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
292:
N-[(3R)-7-[(3aR,6aR)-3a-methoxy-octahydropyrrolo[2,3-c]pyrrol-2-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
293:
3-amino-N-[(6S)-2-[(3S,4S)-3-acetamido-3-methoxypyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinazolin-6-yl]4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
294:
3-amino-N-[(3R)-7-[(3R,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
295:
3-amino-N-[(3R)-7-[(3S,4R)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
296:
3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
297:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
298:
7-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
299:
7-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
300:
3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
3-fluoro-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
301:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
3-fluoro-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
302:
3-amino-N-[(6R)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
3-fluoro-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
303:
3-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
3-fluoro-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
304:
N-[(3R)-7-[(3aS,6aS)-octahydropyrrolo[3,4-b]pyrrol-5-yl]-3,4-dihydro-2H-
1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
305:
N-[(3R)-7-[(3aR,6aR)-octahydropyrrolo[3,4-b]pyrrol-5-yl]-3,4-dihydro-
2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
306:
3-amino-N-[(3R)-7-{2,6-diazaspiro[3.4]octan-6-yl}-3,4-dihydro-2H-1-
benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
307:
3-amino-N-[(3R)-7-[(5S,9S)-9-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
308:
3-amino-N-[(3R)-7-[(5R,9R)-9-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
309:
3-amino-N-[(3R)-7-[(5S,9R)-9-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
310:
3-amino-N-[(3R)-7-[(5R,9S)-9-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
311:
3-amino-N-[(6S)-2-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
312:
3-amino-N-[(6S)-2-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
313:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-(ethoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
314:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-(ethoxymethyl)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
315:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypiperidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
316:
3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-methoxypiperidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
317:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypiperidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
318:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-methoxypiperidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
319:
7-amino-N-[(2S)-6-[(3S,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-
1,2,3,4-tetrahydrophthalen-2-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
320:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
321:
3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
322:
3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
323:
3-amino-N-[(3R)-7-[(3S,4R)-3-amino-4-ethoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
324:
3-amino-N-[(3R)-7-[(3R,4S)-3-amino-4-ethoxypyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
325:
3-amino-N-[(3R)-7-[(3S,4S)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-
2H,3H,4H-pyrano[2,3-b]pyridin-3-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
326:
3-amino-N-[(3R)-7-[(3R,4R)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-
2H,3H,4H-pyrano[2,3-b]pyridin-3-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
327:
3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
328:
3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
329:
N-[(6S)-2-[(4aS,7aS)-4,4-difluoro-octahydro-1H-pyrrolo[3,4-b]pyridin-6-
yl]-5,6,7,8-tetrahydroquinolin-6-yl]-3-amino-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
330:
N-[(6S)-2-[(4aR,7aR)-4,4-difluoro-octahydro-1H-pyrrolo[3,4-b]pyridin-6-
yl]-5,6,7,8-tetrahydroquinolin-6-yl]-3-amino-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
331:
3-amino-N-[(6S)-2-[(3R,4R)-3-hydroxy-3-methyl-4-
(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
332:
3-amino-N-[(6S)-2-[(3S,4R)-3-hydroxy-3-methyl-4-
(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
333:
3-amino-N-[(3R)-7-[(2S,3S,4S)-3-amino-4-methoxy-2-methylpyrrolidin-
1-yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
334:
3-amino-N-[(3R)-7-[(2S,3S,4R)-4-amino-3-methoxy-2-methylpyrrolidin-
1-yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
335:
3-amino-N-[(3R)-7-[(2R,3R,4R)-3-amino-4-methoxy-2-methylpyrrolidin-
1-yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
336:
3-amino-N-[(3R)-7-[(2R,3R,4S)-4-amino-3-methoxy-2-methylpyrrolidin-
1-yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
337:
3-amino-N-[(3R)-7-[(8R)-8-amino-5-oxa-2-azaspiro[3.4]octan-2-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
338:
3-amino-N-[(3R)-7-[(8R)-8-amino-5-oxa-2-azaspiro[3.4]octan-2-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
339:
3-amino-N-[(3R)-7-[(4R,8R)-8-amino-1-oxa-6-azaspiro[3.4]octan-6-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
340:
3-amino-N-[(3R)-7-[(4S,8S)-8-amino-1-oxa-6-azaspiro[3.4]octan-6-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
341:
3-amino-N-[(6S)-2-[(3S,4R)-4-amino-3-(methoxymethyl)-3-
methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
342:
3-amino-N-[(6S)-2-[(3R,4R)-4-amino-3-(methoxymethyl)-3-
methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
343:
3-amino-N-[(6S)-2-[(3S,4S)-4-amino-3-(methoxymethyl)-3-
methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
344:
3-amino-N-[(6S)-2-[(3R,4S)-4-amino-3-(methoxymethyl)-3-
methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
345:
3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
346:
3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
347:
3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
348:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
2H,3H,4H-pyrano[2,3-b]pyridin-3-yl)-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
349:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-
2H,3H,4H-pyrano[2,3-b]pyridin-3-yl)-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
350:
3-amino-N-[(3R)-7-[(3S,4S)-3-hydroxy-4-(methylamino)pyrrolidin-1-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
351:
3-amino-N-[(3R)-7-[(7R)-7-amino-2-oxa-5-azaspiro[3.4]octan-5-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
352:
3-amino-N-[(3R)-7-[(7S)-7-amino-2-oxa-5-azaspiro[3.4]octan-5-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
353:
N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]5,6,7,8-
tetrahydroquinolin-6-yl]-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
354:
3-amino-N-[(6S)-2-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,6,7,8-
tetrahydroquinolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-
carboxamide;
355:
5-chloro-N-[(3R)-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,8-difluoro-3,4-
dihydro-2H-1-benzopyran-3-yl]-7-ethyl-7H-pyrrolo[2,3-c]pyridine-3-
carboxamide;
356:
5-chloro-N-[(3R)-8-cyano-7-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-fluoro-
3,4-dihydro-2H-1-benzopyran-3-yl]-7-ethyl-7H-pyrrolo[2,3-c]pyridazine-
3-carboxamide;
357:
3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(1,1-difluoroethoxy)pyrrolidin-1-
yl]5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
358:
3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(1,1-difluoroethoxy)pyrrolidin-1-
yl]5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
359:
(6aS,7aR)-N-[(2S)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-
(difluoromethyl)-8-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-
5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-naphthyridine-2-carboxamide;
360:
(6aR,7aS)-N-[(2S)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-
(difluoromethyl)-8-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-
5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-naphthyridine-2-carboxamide;
361:
(6aS,7aR)-N-[(2R)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-
(difluoromethyl)-8-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-
5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-naphthyridine-2-carboxamide;
362:
(6aR,7aS)-N-[(2R)-6-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5-
(difluoromethyl)-8-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-
5H,6H,6aH,7H,7aH-cyclopropa[c]1,8-naphthyridine-2-carboxamide;
363:
3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(trifluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
364:
3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(trifluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
365:
7-amino-N-[(6S)-2-[(8R)-8-amino-2-oxa-6-azaspiro[3.4]octan-6-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
366:
7-amino-N-[(6S)-2-[(8S)-8-amino-2-oxa-6-azaspiro[3.4]octan-6-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
367:
3-amino-N-[(6S)-2-[(1R,5S)-9,9-difluoro-2,7-diazabicyclo[3.3.1]nonan-7-
yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
368:
3-amino-N-[(6S)-2-[(1S,5R)-9,9-difluoro-2,7-diazabicyclo[3.3.1]nonan-7-
yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
369:
3-amino-N-[(3R)-7-[(3S)-3-aminopyrrolidin-1-yl]-3,4-dihydro-2H-1-
benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
370:
N-[(6S)-2-[(3R,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
371:
N-[(6S)-2-[(3S,4R)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
372:
3-amino-N-[(6S)-2-[(3R,4S)-3-(difluoromethyl)-4-acetamidopyrrolidin-1-
yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
373:
3-amino-N-[(3R)-7-[3-amino-3-(methoxymethyl)azetidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
374:
3-amino-N-[(6S)-2-[(3S)-3-(difluoromethylpiperazin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
375:
3-amino-N-[(6S)-2-[(3R)-3-(difluoromethylpiperazin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
376:
3-amino-N-[(6S)-2-[(3S,4R)-3-(difluoromethyl)-4-
(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
377:
3-amino-N-[(6S)-2-[(3R,4S)-3-(difluoromethyl)-4-
(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
378:
3-amino-N-[(3R)-7-[(3R,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
2H,3H,4H-pyrano[2,3-b]pyridin-3-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
379:
3-amino-N-[(3R)-7-[(3S,4R)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
2H,3H,4H-pyrano[2,3-b]pyridin-3-yl)-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
380:
3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinozolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
381:
3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinozolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
382:
3-amino-N-[(6R)-2-[(3S,4R)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinozolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
383:
3-amino-N-[(6R)-2-[(3R,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinozolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
384:
3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
385:
3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
386:
3-amino-N-[(6S)-2-[(3R)-3-amino-3-(hydroxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
387:
3-amino-N-[(6S)-2-[(3S)-3-amino-3-(hydroxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
388:
3-amino-N-[(6S)-2-[(3R)-3-amino-3-(hydroxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
389:
3-amino-N-[(6S)-2-[(3S)-3-amino-3-(hydroxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
390:
3-amino-N-[(6S)-2-[(5S,9S)-9-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
391:
3-amino-N-[(6S)-2-[(5S,9S)-9-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
392:
3-amino-N-[(6S)-2-[(5R,9R)-9-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
393:
3-amino-N-[(6S)-2-[(5R,9R)-9-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
394:
N-[(6S)-2-[(3aR,6aS)-3a-amino-hexahydro-1H-furo[3,4-c]pyrrol-5-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
395:
N-[(6S)-2-[(3aS,6aR)-3a-amino-hexahydro-1H-furo[3,4-c]pyrrol-5-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
396:
3-amino-6-methyl-N-[(6S)-2-[(1R,5S,9r)-9-amino-3-oxa-7-
azabicyclo[3.3.1]nonan-9-yl]-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-
b]pyridine-2-carboxamide;
397:
3-amino-6-methyl-N-[(6S)-2-[(1R,5S,9s)-9-amino-3-oxa-7-
azabicyclo[3.3.1]nonan-9-yl]-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-
b]pyridine-2-carboxamide;
398:
3-amino-N-[(6S)-2-[(7R)-7-amino-5-oxa-2-azaspiro[3.4]octan-2-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
399:
3-amino-N-[(6S)-2-[(7S)-7-amino-5-oxa-2-azaspiro[3.4]octan-2-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
400:
N-[(6S)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
401:
N-[(6S)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
402:
1-ethyl-N-[(6S)-2-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
403:
N-[(6S)-2-[(8R)-8-amino-2-oxa-6-azaspiro[3.4]octan-6-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
404:
N-[(6S)-2-[(8S)-8-amino-2-oxa-6-azaspiro[3.4]octan-6-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
405:
3-amino-N-[(6S)-2-[(4R,5S)-4-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
406:
3-amino-N-[(6S)-2-[(4S,5R)-4-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
407:
3-amino-N-[(6S)-2-[(4S,5S)-4-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
408:
3-amino-N-[(6S)-2-[(4R,5R)-4-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
409:
3-amino-N-[(3R)-7-[(4R,5R)-4-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
410:
3-amino-N-[(3R)-7-[(4R,5R)-4-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
411:
3-amino-N-[(3R)-7-[(4S,5S)-4-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
412:
3-amino-N-[(3R)-7-[(4S,5R)-4-amino-1-oxa-7-azaspiro[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
413:
3-amino-N-[(3R)-5-fluoro-7-[(1R)-1-methyl-9-oxa-3,7-
diazabicyclo[3.3.1]nonan-3-yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
414:
3-amino-N-[(3R)-5-fluoro-7-[(1S)-1-methyl-9-oxa-3,7-
diazabicyclo[3.3.1]nonan-3-yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
415:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-methoxypyrrolidin-1-yl]-5,6-
difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
416:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6-
difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
417:
3-amino-N-[(2S)-7,8-difluoro-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
418:
3-amino-N-[(2R)-7,8-difluoro-6-(piperazin-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
419:
3-amino-N-[(6S)-2-[(2R,3R)-3-amino-2-(methoxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
420:
3-amino-N-[(6S)-2-[(2S,3S)-3-amino-2-(methoxymethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
421:
N-[(6S)-2-[(3R,4S)-3-amino-4-(trifluoromethyl)pyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-
carboxamide;
422:
N-[(6S)-2-[(3S,4R)-3-amino-4-(trifluoromethyl)pyrrolidin-1-yl]-5,6,7,8-
tetrahydroquinolin-6-yl]-1-ethyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide;
423:
3-amino-N-[(3R)-7-[(3R,4R)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
424:
3-amino-N-[(3R)-7-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-3,4-
dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
425:
N-[(3R)-7-[(3aS,6R,6aS)-6-amino-hexahydro-2H-furo[3,2-b]pyrrol-4-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
426:
N-[(3R)-7-[(3aR,6R,6aR)-6-amino-hexahydro-2H-furo[3,2-b]pyrrol-4-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-3-amino-6-methylthieno[2,3-
b]pyridine-2-carboxamide;
427:
3-amino-N-[(6S)-2-[(3R,4S)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
428:
3-amino-N-[(6S)-2-[(3S,4R)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
429:
3-amino-N-[(6S)-2-{7-amino-3,3-dioxo-3λ ⊖ thia-9-
azabicyclo[3.3.1]nonan-9-yl}-5,6,7,8-tetrahydroquinolin-6-yl]-6-
methylthieno[2,3-b]pyridine-2-carboxamide;
430:
3-amino-N-[(6S)-2-[(5S,9R)-9-amino-2-oxa-7-azabicyclo[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
431:
3-amino-N-[(6S)-2-[(5R,9S)-9-amino-2-oxa-7-azabicyclo[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
432:
3-amino-N-[(6S)-2-[(5R,9S)-9-amino-2-oxa-7-azabicyclo[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
433:
3-amino-N-[(3R)-7-[(5S,9S)-9-amino-2-oxa-7-azabicyclo[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
434:
N-[(6S)-2-[(3aR,6aS)-3a-methoxy-octahydropyrrolo[2,3-c]pyrrol-5-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
435:
N-[(6S)-2-[(3aS,6aR)-3a-methoxy-octahydropyrrolo[2,3-c]pyrrol-5-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-3-amino-6-methylthieno[2,3-b]pyridine-
2-carboxamide;
436:
3-amino-N-[(2S)-6-[(3R,4R)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
437:
3-amino-N-[(6S)-2-[(5R,9R)-9-amino-2-oxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
438:
3-amino-N-[(6S)-2-[(5S,9S)-9-amino-2-oxa-7-azaspiro[4.4]nonan-7-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
439:
3-amino-N-[(3R)-7-[(5R,9R)-9-amino-2-oxa-7-azaspiro[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
440:
3-amino-N-[(3R)-7-[(5S,9R)-9-amino-2-oxa-7-azaspiro[4.4]nonan-7-yl]-
3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
441:
3-amino-N-[(6S)-2-[(3R,4R)-3-(fluoromethyl)-4-(methylamino)pyrrolidin-
1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
442:
3-amino-N-[(6S)-2-[(3S,4S)-3-(fluoromethyl)-4-(methylamino)pyrrolidin-
1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
443:
3-amino-N-[(3R)-7-[(3R,4R)-3-(fluoromethyl)-4-(methylamino)pyrrolidin-
1-yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
444:
3-amino-N-[(3R)-7-[(3S,4S)-3-(fluoromethyl)-4-(methylamino)pyrrolidin-
1-yl]-3,4-dihydro-2H-1-benzopyran-3-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
445:
3-amino-N-[(6R)-2-[(3R,4R)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
446:
3-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-
5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
447:
3-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-
1,2,3,4-tetrahydronaphthalen-2-yl]-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
448:
N-((2S)-6-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl]-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
449:
N-((2S)-6-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
450:
N-((2R)-6-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl]-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
451:
N-((2R)-6-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl]-3-amino-6-methylthieno[2,3-b]pyridine-2-
carboxamide;
452:
(R)-N-(6-(1,4-diazepan-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-7-
amino-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
453:
7-amino-N-((R)-6-((S)-6-fluoro-1,4-diazepan-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
454:
(S)-7-amino-N-(6-(6,6-difluoro-1,4-diazepan-1-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl]-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
455:
(S)-N-(6-(1,4-diazepan-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-7-
amino-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
456:
N-((2S)-6-(3-oxa-7,9-diazabicyclo[3.3.1]nonan-3-yl)-1,2,3,4-
tetrahydronaphthalen-2-yl]-7-amino-3-methylthieno[2,3-b]pyrazine-6-
carboxamide;
457:
(R)-7-bromo-N-(7-(piperazin-1-yl)chroman-3-yl)-pyrazolo[1,5-a]pyridine-
3-carboxamide;
458:
(R)-7-methyl-N-(7-(piperazin-1-yl)chroman-3-yl)-pyrazolo[1,5-a]pyridine-
3-carboxamide;
459:
(R)-1-acetyl-N-(7-(piperazin-1-yl)chroman-3-yl)-1,2,3,4-
tetrahydronaphthalen-6-carboxamide;
460:
(R)-N-(7-(piperazin-1-yl)chroman-3-yl)pyrazolo[1,5-a]pyridine-3-
carboxamide;
461:
(R)-5-methoxy-N-(7-(piperazin-1-yl)chroman-3-yl)pyrazolo[1,5-
a]pyridine-3-carboxamide;
462:
(R)-6-chloro-N-(7-(piperazin-1-yl)chroman-3-yl)pyrazolo[1,5-a]pyridine-
3-carboxamide;
463:
(R)-5,7-dimethyl-N-(7-(piperazin-1-yl)chroman-3-yl)pyrazolo[1,5-a]pyridine-
3-carboxamide;
464:
(R)-6-chloro-N-(7-(piperazin-1-yl)chroman-3-yl)imidazo[1,2-b]pyridazine-
2-carboxamide;
465:
(R)-5-methyl-N-(7-(piperazin-1-yl)chroman-3-yl)pyrazolo[1,5-a]pyridine-
3-carboxamide;
466:
(R)-N-(7-(piperazin-1-yl)chroman-3-yl)pyrazolo[1,5-a]pyridine-3-
carboxamide;
467:
(R)-6-((3-chlorobemzyl)amino)-N-(7-(piperazin-1-yl)chroman-3-
yl)nicotinamide;
468:
(R)-N-(7-(piperazin-1-yl)chroman-3-yl)-6-((pyridine-3-
ylmethyl)amino)nicotinamide;
469:
(R)-N-(7-(piperazin-1-yl)chroman-3-yl)-6-((3-trifluoromethyl)benzyl)
amino)nicotinamide;
470:
(R)-N-(7-(piperazin-1-yl)chroman-3-yl)-6-((pyridine-3-
ylmethyl)amino)nicotinamide;
471:
(R)-6-(((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)amino)-N-(7-
(piperazin-1-yl)chroman-3-yl)-nicotinamide;
472:
(R)-6-(((2,3-dihydrobenzofuran-5-yl)methyl)amino)-N-(7-(piperazin-1-
yl)chroman-3-yl)-nicotinamide;
473:
(R)-6-((3-acetamidobenzyl)amino)-N-(7-(piperazin-1-yl)chroman-3-
yl)-nicotinamide;
474:
7-ethyl-N-[(3R)-7-(piperazin-1-yl)-3,4-dihydro-2H-1-benzopyran-3-
yl]pyrazolo[1,5-a]pyridine-3-carboxamide;
475:
7-(hydroxymethyl)-N-[(3R)-7-(piperazin-1-yl)-3,4-dihydro-2H-1-
benzopyran-3-yl]pyrazolo[1,5-a]pyridine-3-carboxamide;
or a pharmaceutically acceptable salt thereof.
15. The compound of claim 1 , chosen from the following compounds:
10-1: (R)-3-amino-N-(5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
10-5: (S)-3-amino-N-(5-fluoro-7-(piperazin-1-yl)chroman-3-yl)-6-methylthieno[2,3-b]pyridine-2-carboxamide;
10-15: 3-amino-N-[(3R)-5-fluoro-7-(piperazin-1-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-N,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
10-16: 3-amino-N-[(3S)-5-fluoro-7-(piperazin-1-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-N,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
11-1: N-((2S)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
11-2: N-((2R)-6-(3,8-diazabicyclo[3.2.1]octan-3-yl)-1,2,3,4-tetrahydronaphthalen-2-yl)-3-amino-6-methylthieno[2,3-b]pyridine-2-carboxamide;
23-1: 7-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
23-2: 7-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
23-3: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
23-4: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
23-5: 3-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
23-6: 7-amino-3-methyl-N-[(6S)-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-b]pyrazine-6-carboxamide;
23-7: 3-amino-6-methyl-N-[(6S)-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
23-8: 3-amino-6-methyl-N-[(6R)-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
23-9: 6-amino-2-methyl-N-[(6S)-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-d][1,3]thiazole-5-carboxamide;
23-12: 3-amino-N-[(6S)-2-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
23-13: 7-amino-N-[(6S)-2-{3,8-diazabicyclo[3.2.1]octan-3-yl}-5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
23-14: 3-amino-4,6-dimethyl-N-[(6S)-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
23-17: 3-amino-N-[(6S)-4-fluoro-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
23-18: 3-amino-N-[(6S)-2-{3,8-diazabicyclo[3.2.1]octan-3-yl}-4-fluoro-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
24-1: 3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
24-2: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
25: 3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
26-1: 3-amino-N-[(6S)-2-[(3S,4R)-3-(methoxymethyl)-4-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
26-2: 3-amino-N-[(6S)-2-[(3R,4S)-3-(methoxymethyl)-4-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
27-1: 3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
27-2: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
28-1: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(2-methoxyethoxy)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
28-2: 3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(2-methoxyethoxy)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
29-1: 3-amino-N-[(6S)-2-[(9S)-9-amino-1,4-dioxa-7-azaspiro[4.4]nonan-7-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
29-2: 3-amino-N-[(6S)-2-[(9R)-9-amino-1,4-dioxa-7-azaspiro[4.4]nonan-7-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
30-1: 3-amino-N-[(6S)-3-fluoro-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
30-2: 3-amino-N-[(6R)-3-fluoro-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
31-3: 3-amino-6-methyl-N-[(6′S)-2′-(piperazin-1-yl)-6′,7′-dihydro-5′H-spiro[cyclopropane-1,8′-quinoline]-6′-yl]thieno[2,3-b]pyridine-2-carboxamide;
31-4: 3-amino-6-methyl-N-[(6′R)-2′-(piperazin-1-yl)-6′,7′-dihydro-5′H-spiro[cyclopropane-1,8′-quinoline]-6′-yl]thieno[2,3-b]pyridine-2-carboxamide;
142: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-ethoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
203: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-5-fluoro-6-methylthieno[2,3-b]pyridine-2-carboxamide;
204: 3-amino-5-fluoro-6-methyl-N-[(6S)-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
205: 3-amino-6-methyl-N-[(6S,8S)-8-methyl-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
206: 3-amino-6-methyl-N-[(6R,8S)-8-methyl-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
207: 3-amino-6-methyl-N-[(6S,8R)-8-methyl-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
208: 3-amino-6-methyl-N-[(6R,8R)-8-methyl-2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinolin-6-yl]thieno[2,3-b]pyridine-2-carboxamide;
210: 3-amino-N-[(6S)-2-[(3S,4S)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
211: 3-amino-N-[(6S)-2-[(3R,4R)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
239: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-methoxy-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
240: 3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-methoxy-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
254: 3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-ethoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
255: 3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-ethoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
269: 3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
270: 3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
279: 7-amino-N-[(6S)-2-[(3S,4S)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
280: 7-amino-N-[(6S)-2-[(3R,4R)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
285: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-cyclobutoxypyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
296: 3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
297: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
298: 7-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
299: 7-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-3-methylthieno[2,3-b]pyrazine-6-carboxamide;
300: 3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-3-fluoro-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
301: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-3-fluoro-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
302: 3-amino-N-[(6R)-2-[(3R,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-3-fluoro-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
303: 3-amino-N-[(6R)-2-[(3S,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-3-fluoro-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
311: 3-amino-N-[(6S)-2-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
312: 3-amino-N-[(6S)-2-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
320: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
321: 3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
322: 3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(propan-2-yloxy)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
327: 3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
328: 3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(methoxymethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
331: 3-amino-N-[(6S)-2-[(3R,4S)-3-hydroxy-3-methyl-4-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
332: 3-amino-N-[(6S)-2-[(3S,4R)-3-hydroxy-3-methyl-4-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
341: 3-amino-N-[(6S)-2-[(3S,4R)-4-amino-3-(methoxymethyl)-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
342: 3-amino-N-[(6S)-2-[(3R,4R)-4-amino-3-(methoxymethyl)-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
343: 3-amino-N-[(6S)-2-[(3S,4S)-4-amino-3-(methoxymethyl)-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
344: 3-amino-N-[(6S)-2-[(3R,4S)-4-amino-3-(methoxymethyl)-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
345: 3-amino-N-[(6S)-2-[(3R,4R)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
346: 3-amino-N-[(6S)-2-[(3S,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
347: 3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(difluoromethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
354: 3-amino-N-[(6S)-2-[3,8-diazabicyclo[3.2.1]octan-3-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide;
363: 3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(trifluoromethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
364: 3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(trifluoromethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
376: 3-amino-N-[(6S)-2-[(3S,4R)-3-(difluoromethyl)-4-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
377: 3-amino-N-[(6S)-2-[(3R,4S)-3-(difluoromethyl)-4-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
384: 3-amino-N-[(6S)-2-[(3R,4S)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
385: 3-amino-N-[(6S)-2-[(3S,4R)-3-amino-4-(fluoromethyl)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
427: 3-amino-N-[(6S)-2-[(3R,4S)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
428: 3-amino-N-[(6S)-2-[(3S,4R)-4-amino-3-methoxy-3-methylpyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
430: 3-amino-N-[(6S)-2-[(5S,9R)-9-amino-2-oxa-7-azaspiro[4.4]nonan-7-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
431: 3-amino-N-[(6S)-2-[(5R,9S)-9-amino-2-oxa-7-azaspiro[4.4]nonan-7-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
437: 3-amino-N-[(6S)-2-[(5R,9R)-9-amino-2-oxa-7-azaspiro[4.4]nonan-7-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide;
441: 3-amino-N-[(6S)-2-[(3R,4R)-3-(fluoromethyl)-4-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide; or
442: 3-amino-N-[(6S)-2-[(3S,4S)-3-(fluoromethyl)-4-(methylamino)pyrrolidin-1-yl]-5,6,7,8-tetrahydroquinolin-6-yl]-6-methylthieno[2,3-b]pyridine-2-carboxamide.