Occlusion device
Provided herein is an occlusion device comprising: (a) continuous mesh structure comprising a medial pinch point; (b) a resilient mesh disc-shaped body extending distally and outward from the medial pinch point; and (c) a compressible mesh carriage extending distally from the medial pinch point on an opposing side of the resilient mesh body of (b), wherein the compressible mesh carriage comprises a pinch point on each end of the carriage, wherein one of the pinch points is the medial pinch point of (a); wherein the continuous mesh structure has a first delivery shape and a second expandable deployed shape, and wherein the length (x) of the resilient mesh body is greater than the length (y) of the compressible mesh carriage in free air and in the deployed shape. Also provided herein is a kit comprising the occlusion device disclosed herein and a means for delivery thereof. Methods of manufacture and use of the occlusion device disclosed herein are also disclosed.
1. An occlusion device comprising:
a continuous mesh structure comprising: a continuous resilient mesh disc-shaped body extending distally and outward from a first side of a first marker, wherein the continuous resilient mesh disc-shaped body has an exposed internal surface that has a convex portion adjacent the first marker, followed by a concave portion toward a distal end of the continuous resilient mesh disc-shaped body, and cii) a compressible continuous mesh carriage extending proximally-from a second side of the first marker to a first side of a second marker,
wherein the first side of the second maker faces the second side of the first marker and the compressible mesh carriage comprises a pinch point in the first and second marker on each end of the compressible continuous mesh carriage, and one of the compressible continuous mesh carriage end pinch points is a medial pinch point of the continuous mesh structure, wherein each pinch point on the ends of the compressible continuous mesh carriage is a constrained and gathered location on the continuous mesh structure, and wherein
the continuous mesh structure has a first delivery shape and a second expandable deployed shape, the continuous resilient mesh disc-shaped body having a first outer-most diameter and the compressible continuous mesh carriage mesh carriage having a second outer-most diameter, wherein the first outer-most diameter is greater than the second outer-most diameter in free air and in the deployed shape.
2. The occlusion device of claim 1 , wherein the second marker encircles at least one pinch point of the continuous mesh structure.
3. The occlusion device of claim 1 , wherein the continuous mesh structure expands to the deployed shape and is configured to fill a body lumen or aneurysm.
4. The occlusion device of claim 1 , wherein the continuous mesh structure has an open mesh density for enhanced tissue integration and/or stabilization of the occlusion device.
5. The occlusion device of claim 1 , wherein the continuous resilient mesh disc-shaped body of the occlusion device is single-layer mesh.
6. The occlusion device of claim 1 , wherein the continuous resilient mesh disc-shaped body of the occlusion device is a dual or double layer mesh.
7. The occlusion device of claim 6 , wherein the dual or double layer mesh comprises a single layer of mesh folded circumferentially.
8. The occlusion device of claim 1 , wherein the continuous resilient mesh disc-shaped body and the compressible continuous mesh carriage are closed on all sides.
9. A kit for treatment and/or amelioration of an aneurysm; the kit the occlusion device according to claim 1 ; and
a delivery system or detachment system corresponding to the occlusion device.
10. The kit of claim 9 , wherein the delivery system is a microcatheter, catheter, guide wire, or pusher wire.
11. The kit of claim 9 , wherein the detachment system is an electrolytic detachment system.
12. A method for treating or ameliorating an aneurysm in a patient, the method comprising:
delivering to an aneurysm the occlusion device according to claim 1 ; and
deploying the occlusion device in the aneurysm, thereby treating or ameliorating the aneurysm in the patient.