Compositions and methods for increasing butyrate production
Provided herein are compositions and methods for increasing butyrate production in a subject. In particular, provided herein are compositions, probiotic compositions, and combinations thereof that promote butyrate production in a subject.
1. A method of increasing butyrate levels in the intestine of a subject, comprising:
a) assaying a sample from a subject for the presence of Clostridium seq 176 and/or Ruminococcus bromii ; and
b) administering a composition comprising a potato starch and one or both of Clostridium seq 176 and/or Ruminococcus bromii to a subject lacking said Clostridium seq 176 and/or Ruminococcus bromii, wherein said composition comprises said Clostridium seq 176 and/or Ruminococcus bromii that the subject lacks.
2. The method of claim 1 , wherein said composition is a capsule.
3. The method of claim 1 , wherein said composition is administered orally.
4. The method of claim 1 , wherein said composition is administered rectally.
5. The method of claim 4 , wherein said composition is a suppository.
6. The method of claim 1 , wherein said subject is a human.
7. The method of claim 1 , wherein the increased level of butyrate is increased relative to a control selected from the group consisting of the level in an individual not administered said composition, the level in an individual diagnosed with a disease or conditions related to low butyrate levels, and an sub-optimal level of butyrate.
8. The method of claim 1 , wherein said administering results in a decrease in signs or symptoms of a disease or condition.
9. The method of claim 8 , wherein said disease or condition is selected from the group consisting of inflammatory bowel diseases, type II diabetes, metabolic syndrome, obesity, cancer, and graft versus host disease.
10. The method of claim 1 , wherein said Clostridium seq 176 has a 16S rRNA V4 region sequence of SEQ ID NO:1 or sequences at least 95% identical to SEQ ID NO:1.
11. A method of treating a disease or condition associated with low levels of butyrate in the intestine of a subject, comprising:
a) assaying a sample from a subject for the presence of Clostridium seq 176 and/or Ruminococcus bromii ; and
b) administering a composition comprising a potato starch and one or both of Clostridium seq 176 and/or Ruminococcus bromii to a subject lacking said Clostridium seq 176 and/or Ruminococcus bromii, wherein said composition comprises said Clostridium seq 176 and/or Ruminococcus bromii that the subject lacks.
12. The method of claim 1 , further comprising administering at least one second bacteria selected from the group consisting of bacteria belonging to the taxons identified as Faecalibacterium prausnitzii, Eubacterium rectale, Roseburia spp., Eubacterium hallii , and Anaerostipes hadrus to said subject.
13. The method of claim 11 , further comprising administering at least one second bacteria selected from the group consisting of bacteria belonging to the taxons identified as Faecalibacterium prausnitzii, Eubacterium rectale, Roseburia spp., Eubacterium hallii , and Anaerostipes hadrus to said subject.
14. The method of claim 13 , wherein said Roseburia spp. is selected from the group consisting of Roseburia faecis, Roseburia intestinalis , and Roseburia inulinivorans.