Aqueous oral care fluoride treatment compositions, and methods

1. An aqueous oral care fluoride treatment composition comprising:

a water-soluble N-containing polymer present in an amount of 0.5 wt-% to 4.8 wt-%;

sodium fluoride present in an amount of 1.0 wt-% to 2.5 wt-%;

a water-soluble calcium salt;

water present in an amount of at least 60 wt %; and

a pharmaceutically acceptable buffer;

wherein the weight percentages are based on the total weight of the aqueous composition.

2. The aqueous oral care fluoride treatment composition of claim 1 , wherein the water-soluble N-containing polymer is present in an amount of 0.6 wt-% to 4.0 wt-%.

3. The aqueous oral care fluoride treatment composition of claim 1 , wherein the water-soluble N-containing polymer is selected from a (meth)acrylate copolymer having dimethylaminoethyl side groups, apolyethyleneimine, a cationic-modified polysaccharide, and a combination thereof.

4. The aqueous oral care fluoride treatment composition of claim 3 , wherein the water-soluble N-containing polymer is selected from:

wherein n=50-2000;

wherein x=200-20,000, and y=200-20,000;

wherein n=5,000-1,000,000;

wherein n=10-1,000;

and a combinations thereof.

5. The aqueous oral care fluoride treatment composition of claim 1 , further comprising a thickener.

6. The aqueous oral care fluoride treatment composition of claim 5 , wherein the thickener is present in an amount sufficient to provide the composition with a viscosity of 0.5 to 100 Pascal seconds at a shear rate of 1.0/second.

7. The aqueous oral care fluoride treatment composition of claim 5 , wherein the thickener is present in an amount of less than 2.5 wt-%.

8. The aqueous oral care fluoride treatment composition of claim 1 , wherein the water-soluble calcium salt is selected from calcium chloride, calcium nitrate, calcium gluconate, calcium lactate gluconate, calcium acetate, hydrates thereof, and a combination thereof.

9. The aqueous oral care fluoride treatment composition of claim 1 , which has a pH of 6 to 8.

10. The aqueous oral care fluoride treatment composition of claim 1 , comprising less than 5 wt-% organic solvent.

11. The aqueous oral care fluoride treatment composition of claim 1 , which releases at least 50% of the sodium fluoride in 5 minutes or less.

12. The aqueous oral care fluoride treatment composition of claim 1 , which releases no greater than 90% of the sodium fluoride in 1 minute or less.

13. The aqueous oral care fluoride treatment composition of claim 1 , which releases 100% of the sodium fluoride in 10 minutes or less.

14. The aqueous oral care fluoride treatment composition of claim 1 , comprising up to 96 wt-% water.

15. A method of providing fluoride to a tooth surface of a subject, the method comprising applying an aqueous oral care fluoride treatment composition of claim 1 to the tooth surface of the subject.

16. The method of claim 15 , wherein applying comprises painting the aqueous oral care fluoride treatment composition on the tooth surface of the subject.

17. The method of claim 15 , wherein the applying comprises dispensing the treatment composition into a dental tray and attaching the dental tray having the aqueous oral care fluoride treatment composition therein to the tooth surface of the subject.

18. The method of claim 17 , wherein the dental tray comprises an orthodontic aligner treatment tray.

19. A method of reducing the incidence of dental caries in a subject in need thereof, the method comprising applying an aqueous oral care fluoride treatment composition of claim 1 to a tooth surface of the subject.

20. The aqueous oral care fluoride treatment composition of claim 1 , wherein the water-soluble calcium salt is present in an amount of 0.5 wt % to 1.5 wt % based on the total weight of the aqueous oral care fluoride composition.

21. The aqueous oral care fluoride treatment composition of claim 1 , wherein the water-soluble N-containing polymer is cationic.