Meroterpenoid compounds for use in the prevention and treatment of a neurological disorder
The present invention relates to a compound, in particular a meroterpenoid compound, or salt thereof, for use in the prevention and/or treatment of a neurological disorder in an individual. The compound of the invention can promote lactate secretion. A composition comprising the compound of the invention, and a food or food extract enriched with said compound or composition is also provided.
1. A method of increasing lactate secretion from brain cells of an elderly human, the method comprising administering a compound to the elderly human, the compound having the structural formula (Ib)
wherein R1=a halogen;
R2=cyclized isoprenoid chain with 5 to 19 carbon atoms, hydrogen, and optionally oxygen, and optionally with further esterification; and
R3=H or OH.
2. The method according to claim 1 , wherein the compound has the structural formula
wherein R1=a halogen;
R2=cyclized isoprenoid chain with 5 to 19 carbon atoms, hydrogen, and optionally oxygen; and
R3=H or OH.
3. The method according to claim 1 , wherein R1=Cl, and R3=H.
4. The method according to claim 1 , wherein the compound is ascochlorin.
5. The method according to claim 1 , where the compound is Illicicolin C (CAS 22562-67-0).
6. The method according to claim 1 , where the compound is Illicicolin F (CAS 22738-98-3).
7. The method according to claim 1 , wherein the lactate secretion from astrocytes is promoted.
8. The method according to claim 1 , wherein the elderly human has a neurodegenerative disorder selected from the group consisting of Alzheimer's disease, Huntington's disease, Parkinson's disease, Tourette's syndrome, and combinations thereof.
9. The method according to claim 1 , wherein the elderly human has cognitive impairment.