Coacervate formed from catechol-substituted anionic polymer, adhesive comprising same, and method for producing same
A coacervate including a catechol-substituted anionic polymer; an adhesive including same; and a method for producing the coacervate are described. More specifically, a coacervate formed by mixing a catechol derivative of a mussel adhesive protein and a catechol-substituted anionic polymer; an adhesive including the coacervate; and a method for producing a coacervate are described. The method includes a step of obtaining a catechol-substituted anionic polymer through catechol substitution of an anionic polymer, and a step of mixing the catechol-substituted anionic polymer and a catechol derivative of a mussel adhesive protein.
1. A coacervate comprising:
a mixture of:
a catechol derivative of a modified mussel adhesive protein in which a tyrosine residue is modified as a catechol derivative, and
a catechol-substituted hyaluronic acid as anionic polymer, wherein a substitution degree of the hyaluronic acid is 10% to 52%.
2. The coacervate of claim 1 , wherein the catechol derivative of the mussel adhesive protein comprises 10% to 100% of a total number of tyrosine residues the mussel adhesive protein is a catechol derivative substitution.
3. The coacervate of claim 1 , wherein the catechol derivative is at least one selected from the group consisting of 3,4-dihydroxyphenylalanine (DOPA), DOPA o-quinone, 2,4,5-trihydroxyphenylalanine (TOPA), TOPA quinone and a derivative thereof.
4. The coacervate of claim 1 , wherein a molecular weight of the hyaluronic acid is 1 kDa to 5000 kDa.
5. The coacervate of claim 1 , wherein the substitution degree is 30% to 50%.
6. The coacervate of claim 1 , wherein the substitution degree is 35% to 50%.
7. An adhesive comprising the coacervate claim 1 .