IP Library Granted Patent US 11,247,960
Granted Patent B2
US 11,247,960 · App. 16/649,805 · Granted Feb 15, 2022

Method for producing fluorinated compounds

Inventors: Reiner Friedrich (Seeheim-Jugenheim, DE); Fabian Koch (Pfungstadt, DE)
Assignee: MERCK PATENT GMBH
C07C41/14C07C17/2637C07C17/272C07C41/03C07C43/137C07D303/24C09D5/006C09D7/40C09D7/61
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Quick Facts
Patent No.
US 11,247,960
App. No.
16/649,805
Granted
Feb 15, 2022
Kind
B2
Abstract

The present invention relates to a process for the preparation of fluorinated compounds, to novel compounds containing fluorinated end groups, to the use thereof and to compositions comprising novel compounds containing fluorinated end groups.

Claims (46)

1. A process for preparing a compound of formula (I)

comprising

first preparing a compound of formula (II)

in a step a) by reacting a compound of formula (III) with glycidol (IV) to give a compound of formula (II)

and

converting said compound of formula (II) into a compound of formula (I), in a step b) by reacting the compound of formula (II) with an alcohol of formula (V) to give a compound of formula (I)

where

Rf is CF 3 —(CF 2 ) 0-3 —O—,

R is a linear or branched alkyl or siloxane group, optionally containing one or more heteroatoms, or a group Rf′, and

Rf′ is a fluorinated, linear or branched alkyl group, optionally containing one or more heteroatoms.

2. The process according to claim 1 , wherein Rf′ is of the following formula

CF 3 —(CF 2 ) a —O b —(CF 2 ) c —O d —(CR 1 R 2 ) e —(CR 3 R 4 ) f —O g —,

where

R 1 , R 2 , R 3 and R 4 , independently of one another, are hydrogen or an alkyl group,

a=0, 1, 2 or 3,

b=0 or 1,

c=0, 1, 2 or 3,

d=0 or 1,

e=0, 1, 2, 3 or 4,

f=0, 1, 2, 3 or 4 and

g=0 or 1.

3. The process according to claim 1 , wherein Rf and Rf′ are different.

4. The process according to claim 1 , wherein Rf′ is a fluorinated C 1 -C 6 -alkyl group.

5. The process according to claim 1 , wherein R is a C 1 -C 20 alkyl group.

6. The process according to claim 1 , wherein Rf and/or Rf′ is a perfluorinated C 1 -C 4 -alkyl group.

7. The process according to claim 1 , wherein Rf and/or Rf′ is a perfluorinated C 3 -alkyl group.

8. The process according to claim 1 , wherein R is a C 6 -C 14 alkyl group.

9. The process according to claim 1 , wherein R is a siloxane group.

10. The process according to claim 1 , wherein R is Rf′.

11. The process according to claim 1 , wherein one of the following compounds of formula I is prepared

12. A process for preparing a compound of formula (I)

comprising

first preparing a compound of formula (II)

in a step a) by reacting a compound of formula (III) with glycidol (IV) to give a compound of formula (II)

and

converting said compound of formula (II) into a compound of formula (I), in a step b) by reacting the compound of formula (II) with an alcohol of formula (V) to give a compound of formula (I)

where

Rf is a fluorinated, linear or branched alkyl group, optionally containing one or more heteroatoms,

R is a siloxane group, optionally containing one or more heteroatoms.

13. The process according to claim 12 , wherein Rf is of the following formula

CF 3 —(CF 2 ) a —O b —(CF 2 ) c —O d —

where

a=0, 1, 2 or 3,

b=0 or 1,

c=0, 1, 2 or 3 and

d=0 or 1.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 28, 2025
From: MERCK PATENT GMBH
To: SUSONITY COMMERCIAL GMBH
Reel/Frame 072287/0400 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2020
From: KOCH, FABIAN; FRIEDRICH, REINER
To: MERCK PATENT GMBH
Reel/Frame 052195/0588 →
Priority Claims (1)
EP 17193044 · Sep 26, 2017 · regional
Continuity (1)
Related Publication 20200277247A1 · Sep 3, 2020