Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease
Pharmaceutical compositions are described, the compositions comprising therapeutically effective quantities of compounds (such as mycophenolic acid or cyclosporine) that are capable of treating, preventing, and/or or alleviating an ocular surface disease. Methods for fabricating the compositions and using them are also described.
1. A pharmaceutical composition for topical administration to an eye, the composition comprising:
a. mycophenolic acid or a pharmaceutically acceptable salt thereof at a concentration of about 0.1% w/w;
b. a lubricating agent;
c. chondroitin sulfate; and
d. a pharmaceutically acceptable carrier.
2. The pharmaceutical composition of claim 1 , wherein the mycophenolic acid or the pharmaceutically acceptable salt thereof is at a concentration of 0.1% w/w.
3. The pharmaceutical composition of claim 1 , wherein the lubricating agent is glycerol.
4. The pharmaceutical composition of claim 1 , wherein the concentration of the lubricating agent is from about 0.1% w/w to about 5.0% w/w.
5. The pharmaceutical composition of claim 1 , wherein the concentration of the chondroitin sulfate is from about 0.1% w/w to about 5.0 w/w.
6. A topical composition for the treatment of dry eye disease comprising the pharmaceutical composition of claim 1 packaged as eye drops.
7. A pharmaceutical composition for topical administration to an eye, the composition comprising:
a. mycophenolic acid or a pharmaceutically acceptable salt thereof at a concentration of about 0.1% w/w;
b. chondroitin sulfate; and
c. a pharmaceutically acceptable carrier.
8. The pharmaceutical composition of claim 7 , wherein the mycophenolic acid or the pharmaceutically acceptable salt thereof is at a concentration of 0.1% w/w.
9. The pharmaceutical composition of claim 7 , wherein the chondroitin sulfate is at a concentration from about 0.1% w/w to about 5.0% w/w.
10. The pharmaceutical composition of claim 9 , wherein the chondroitin sulfate is at a concentration of 0.25% w/w.
11. The pharmaceutical composition of claim 7 , further comprising a corticosteroid.
12. The pharmaceutical composition of claim 11 , wherein the corticosteroid comprises betamethasone sodium phosphate.
13. The pharmaceutical composition of claim 7 , further comprising glycerol.
14. The pharmaceutical composition of claim 13 , wherein the glycerol is at a concentration from about 0.1% w/w to about 5.0 w/w.
15. A topical composition for the treatment of dry eye disease comprising the pharmaceutical composition of claim 7 packaged as eye drops.