IP Library Granted Patent US 10,613,110
Granted Patent B2
US 10,613,110 · App. 16/653,537 · Granted Apr 7, 2020

Pipettor system

Inventors: Michael Nichols (Brookline, MA); Louis J. Guarracina (Newburyport, MA)
Assignee: HIGHRES BIOSOLUTIONS, INC.
G01N35/1072B01L3/0227B01L3/0237G01N35/0099G01N35/10G01N35/1011G01N35/1065G01N2035/1076
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Quick Facts
Patent No.
US 10,613,110
App. No.
16/653,537
Granted
Apr 7, 2020
Kind
B2
Abstract

Various embodiments include a system having a pipetting chamber, a set of pipettor cartridges docked in the pipetting chamber, a gantry system mounted on a ceiling within the pipetting chamber, the gantry system including at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track, and a carrier configured to transport each of the set of pipettor cartridges to a pipetting location within the pipetting chamber, the carrier configured to move each pipettor cartridge in a third direction perpendicular to both the first and second directions.

Claims (45)

1. A method comprising:

providing a pipetting chamber having a ceiling within the pipetting chamber;

docking a set of pipettor cartridges on the ceiling within the pipetting chamber;

providing a tray dock movably mounted within the pipetting chamber;

providing a gantry system mounted on the ceiling within the pipetting chamber, the gantry system having at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track;

transporting, with a carrier, each pipettor cartridge of the set of pipettor cartridges to a pipetting location within the pipetting chamber, where the carrier moves each pipettor cartridge in a third direction perpendicular to both the first and second directions;

controlling movement, with a control system coupled with the pipetting chamber, of the carrier along the first direction, the second direction, and the third direction; and

moving the tray dock within the pipetting chamber relative to the pipetting location, where the tray dock has more than one tray dock sections each being separate and distinct from each other and each of the more than one tray dock sections docks with a different corresponding pipetting tray; and

swapping the different corresponding pipetting trays at the pipetting location by moving each of the more than one tray dock sections past each other relative to the pipetting location.

2. The method of claim 1 , wherein each pipettor cartridge of the set of pipettor cartridges is provided with a casing, a mount on a top side of the casing, a set of pipettes extending from a bottom side of the casing, and an access door on a side of the casing between the top side and the bottom side.

3. The method of claim 1 , further comprising rotating the carrier about an axis of the carrier to at least one of engage a pipettor cartridge, disengage a pipettor cartridge, or facilitate pipetting via a pipettor cartridge, wherein the axis of the carrier is parallel to the third direction.

4. The method of claim 1 , further comprising providing a storage chamber, coupled to the pipetting chamber, wherein the storage chamber stores pipetting trays.

5. The method of claim 4 , further comprising:

providing a set of fluid reservoirs coupled with an exterior of at least one of the storage chamber or the pipetting chamber; and

providing a set of fluid conduits fluidly connected with the set of fluid reservoirs and the set of pipettor cartridges through the pipetting chamber.

6. The method of claim 4 , further comprising:

providing the storage chamber with a robotic arm, wherein the robotic arm moves the pipetting trays between the pipetting chamber and the storage chamber; and

providing the storage chamber with a storage carousel, wherein the storage carousel stores pipetting trays.

7. The method of claim 6 , further comprising:

moving, with the robotic arm, the pipetting trays between the pipetting chamber and the storage chamber in a Z direction; and

moving, with the robotic arm, the pipetting trays in X and Y directions within each of the pipetting chamber and the storage chamber.

8. The method of claim 1 , wherein the more than one tray dock sections are disposed within the pipetting chamber to move freely past each other and a pipettor cartridge on the carrier at the pipetting location and swap the different corresponding pipetting trays at the pipetting location.

9. The method of claim 1 , further comprising effecting replacement, with the gantry system, at the pipetting location of a pipettor cartridge of the set of pipettor cartridges with another pipettor cartridge of the set of pipettor cartridges independent of tray dock section movement swapping the different corresponding pipettor trays at the pipetting location, wherein the carrier moves freely in the first, second, and third direction between the pipetting location and different docking locations of the set of pipettor cartridges.

10. The method of claim 1 , further comprising swapping the different corresponding pipetting trays at an opening location of a tray passage opening between a storage chamber and the pipetting chamber, the opening location being away from the pipetting location, wherein each tray dock section moves past each other tray dock section relative to the opening location and the storage chamber is coupled to the pipetting chamber.

11. The method of claim 1 , wherein at least a corresponding pipetting tray docked to one of the more than one tray dock sections is of a different type than another corresponding pipetting tray docked to another of the more than one tray dock sections.

12. The method of claim 1 , wherein the more than one tray dock sections include a number of tray dock sections so that swapping movement of tray dock sections is effected at the pipetting location with a tray dock section located at the opening location.

13. The method of claim 1 , wherein the more than one tray dock sections include a number of tray dock sections so that swapping movement of tray dock sections is effected at the opening location with a tray dock section located at the pipetting location.

14. A method comprising:

providing a pipetting chamber having a ceiling within the pipetting chamber;

docking a set of pipettor cartridges on the ceiling within the pipetting chamber

providing a tray dock movably mounted within the pipetting chamber;

providing a gantry system mounted on the ceiling within the pipetting chamber, the gantry system having at least one stationary track aligned in a first direction, and a movable track aligned in a second direction distinct from the first direction, the movable track coupled to the at least one stationary track;

transporting, with a carrier, each pipettor cartridge of the set of pipettor cartridges to a pipetting location within the pipetting chamber, where the carrier moves each pipettor cartridge in a third direction perpendicular to both the first and second directions, and where the carrier moves completely circumferentially about the set of pipettor cartridges docked on the ceiling;

controlling movement, with a control system coupled with the pipetting chamber, of the carrier along the first direction, the second direction, and the third direction; and

moving the tray dock within the pipetting chamber relative to the pipetting location, where the tray dock has more than one tray dock sections each being separate and distinct from each other and each of the more than one tray dock sections docks with a different corresponding pipetting tray; and

swapping the different corresponding pipetting trays at the pipetting location by moving each of the more than one tray dock sections past each other relative to the pipetting location.

15. The method of claim 14 , further comprising:

moving, with a robotic arm, the different corresponding pipetting trays between the pipetting chamber and a storage chamber in a Z direction; and

moving, with the robotic arm, the pipetting trays in X and Y directions within each of the pipetting chamber and the storage chamber.

16. The method of claim 14 , wherein the more than one tray dock sections are disposed within the pipetting chamber to move freely past each other and a pipettor cartridge on the carrier at the pipetting location and swap the different corresponding pipetting trays at the pipetting location.

17. The method of claim 14 , further comprising effecting replacement, with the gantry system, at the pipetting location of a pipettor cartridge of the set of pipettor cartridges with another pipettor cartridge of the set of pipettor cartridges independent of tray dock section movement swapping the different corresponding pipettor trays at the pipetting location, wherein the carrier moves freely in the first, second, and third direction between the pipetting location and different docking locations of the set of pipettor cartridges.

18. The method of claim 14 , further comprising swapping the different corresponding pipetting trays at an opening location of a tray passage opening between a storage chamber and the pipetting chamber, the opening location being away from the pipetting location, wherein each tray dock section moves past each other tray dock section relative to the opening location and the storage chamber is coupled to the pipetting chamber.

19. The method of claim 14 , wherein at least a corresponding pipetting tray docked to one of the more than one tray dock sections is of a different type than another corresponding pipetting tray docked to another of the more than one tray dock sections.

20. The method of claim 14 , wherein the more than one tray dock sections include a number of tray dock sections so that swapping movement of tray dock sections is effected at the pipetting location with a tray dock section located at the opening location.

21. The method of claim 14 , wherein the more than one tray dock sections include a number of tray dock sections so that swapping movement of tray dock sections is effected at the opening location with a tray dock section located at the pipetting location.

Assignments (2)
SECURITY INTEREST Recorded Jan 4, 2022
From: HIGHRES BIOSOLUTIONS
To: SANTANDER BANK, N.A.
Reel/Frame 058543/0064 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2019
From: NICHOLS, MICHAEL; GUARRACINA, LOUIS J.
To: HIGHRES BIOSOLUTIONS, INC.
Reel/Frame 050722/0284 →
Continuity (4)
Continuation 15883738 · Jan 30, 2018
Continuation 15454122 · Mar 9, 2017
Continuation 14636962 · Mar 3, 2015
Related Publication 20200041534A1 · Feb 6, 2020
Cited By (1)
US 12,674,810