IP Library Granted Patent US 10,953,014
Granted Patent B2
US 10,953,014 · App. 16/654,889 · Granted Mar 23, 2021

7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy

Inventors: Martin Stogniew (Lakewood Ranch, FL); Joshua E. Allen (New Haven, CT)
Assignee: ONCOCEUTICS, INC.
A61K31/519A61K31/337A61K31/395A61K31/4188A61K31/4545A61K31/513A61K45/06C07D471/14
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Quick Facts
Patent No.
US 10,953,014
App. No.
16/654,889
Granted
Mar 23, 2021
Kind
B2
Abstract

This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.

Claims (4)

1. A method of treatment comprising administering to a subject having ovarian cancer in need of such treatment a pharmaceutically acceptable amount of compound (1):

or a pharmaceutically acceptable salt thereof, wherein the pharmaceutically acceptable amount of compound (1) is administered as a salvage therapy.

2. A method of treatment, comprising administering to a subject in need of such treatment a therapeutic agent comprising compound (1):

or a pharmaceutically acceptable salt thereof, wherein the treatment is for a genitourinary cancer and wherein the genitourinary cancer is ovarian cancer.

Assignments (2)
CONFIRMATORY PATENT ASSIGNMENT Recorded Oct 27, 2025
From: CHIMERIX, INC.; ONCOCEUTICS, INC.
To: JAZZ PHARMACEUTICALS IRELAND LIMITED
Reel/Frame 073333/0883 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 18, 2020
From: STOGNIEW, MARTIN; ALLEN, JOSHUA E.
To: ONCOCEUTICS, INC.
Reel/Frame 051845/0309 →