Interleukin 15 (IL-15) variants
The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
1. An isolated human interleukin 15 (hIL-15) variant comprising an Asn to Ala substitution at position 65 of SEQ ID NO:1.
2. An isolated hIL-15 variant comprising a Glu to Ala or a Glu to Ser substitution at position 92 of SEQ ID NO:1.
3. The hIL-15 variant of claim 2 , comprising E92A.
4. The hIL-15 variant of claim 2 , comprising E92S.
5. An isolated hIL-15 variant comprising an Ile to Ala or an Ile to Ser substitution at position 111 of SEQ ID NO:1.
6. The hIL-15 variant of claim 5 , comprising I111A.
7. The hIL-15 variant of claim 5 , comprising I111S.