DOSING REGIMEN FOR INJECTABLE CETIRIZINE
Described herein is a method of administering injectable cetirizine or levocetirizine including intravenously injecting a mammal in need thereof with a therapeutically effective amount of an injectable cetirizine or levocetirizine composition, wherein the mammal receives a maximum daily dose of the cetirizine or levocetirizine that is no more than 15 times a maximum recommended daily clinical dose for the mammal.
1 . A method of administering injectable cetirizine or levocetirizine to treat acute urticaria, comprising
intravenously injecting a human patient in an emergency department or clinic with a therapeutically effective amount of an injectable cetirizine or levocetirizine composition,
determining, by the patient, a patient rated pruritus severity score at baseline and at a 1 hour assessment, and
a physician determining readiness to discharge as effective treatment of the acute urticaria based on the patient rated pruritus score reduction of at least 1 unit at the 1 hour assessment compared to the baseline assessment, wherein the human patient spends 1.7±0.9 hours in the emergency department or clinic.
2 . The method of claim 1 , wherein the therapeutically effective amount is the maximum recommended daily clinical dose.
3 . The method of claim 2 , wherein the maximum recommended human daily clinical dose is 2.5, 5 or 10 mg of cetirizine dihydrochloride administered once daily.
4 . The method of claim 3 , wherein the human subject is a child 6 months to 5 years and the maximum recommended human daily clinical dose of cetirizine dihydrochloride is 2.5 mg; the human subject is a child 6 to 11 years and the recommended human daily clinical dose of cetirizine dihydrochloride is 5 or 10 mg; or the human subject is an adult of adolescent 12 years or older and the maximum recommended daily clinical dose of cetirizine dihydrochloride is 10 mg.
5 . The method of claim 2 , wherein the maximum recommended human daily clinical dose is 1.25, 2.5 or 5 mg of levocetirizine dihydrochloride administered once daily.
6 . The method of claim 5 , wherein the human subject is a child 6 months 5 years and the recommended human daily clinical dose of levocetirizine dihydrochloride is 1.25 mg; the human subject is a child 6 to 11 years and the recommended human daily clinical dose of levocetirizine dihydrochloride is 2.5 or 5 mg; or the human subject is an adult of adolescent 12 years or older and the recommended daily clinical dose of levocetirizine dihydrochloride is 5 mg.
7 . The method of claim 1 , wherein the human patient returns to the emergency department or clinic.
8 . (canceled)
9 . The method of claim 1 , wherein the human subject has concomitant angioedema.
10 . The method of claim 1 , wherein the cetirizine dihydrochloride composition is a 10 mg/mL aqueous solution.