Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer
The present invention concerns the use of interleukin-8 (IL-8) as a biomarker for predicting the outcome of the treatment with aflibercept, or ziv-aflibercept of a patient suspected to suffer from a cancer.
1. A method of determining the therapeutic efficacy of aflibercept or ziv-aflibercept in a patient with colon cancer, colorectal cancer, or rectal cancer, comprising subjecting a biological sample from the patient to at least one assay to measure the IL-8 expression level in the biological sample, and comparing the measured IL-8 expression level to a reference level of IL-8, wherein an IL-8 expression level measured in the biological sample lower than the reference level is indicative of the therapeutic efficacy of aflibercept in said patient.
2. The method of claim 1 , wherein the colon cancer is metastatic colon cancer.
3. The method of claim 1 , wherein the colorectal cancer is metastatic colorectal cancer.
4. The method of claim 1 , wherein the rectal cancer is metastatic rectal cancer.
5. The method of claim 1 , wherein the reference level of IL-8 is between about 10 and about 30 pg/mL.
6. The method of claim 1 , wherein the reference level of IL-8 is about 19 pg/mL.
7. The method of claim 1 , wherein the biological sample is selected from the group consisting of blood, serum and plasma.
8. The method of claim 1 , wherein the IL-8 level is a circulating level.
9. The method of claim 1 , wherein the patient has previously been treated with oxaliplatin or bevacizumab.
10. The method of claim 1 , wherein the reference level of IL-8 is the expression level of IL-8 in a subject without cancer.