IP Library › Granted Patent US 11,963,709
Granted Patent B2
US 11,963,709 · App. 16/663,773 · Granted Apr 23, 2024

Method and system for consistent, repeatable, and safe cryospray treatment of airway tissue

Inventors: Wendelin Maners (Hermosa Beach, CA); Ellen Sheets (Boston, MA); Rafael Cordero (Bedford, MA); Marc Davidson (Andover, MA); Wei Li Fan (Boston, MA); David Sherrill (Westford, MA); Brian M. Hanley (Reading, MA); Amy Sarli (Framingham, MA); Stephen Griffin (San Jose, CA); Heather V. Hawkes (Trumbull, CT)
Assignee: CSA Medical, Inc.
A61B18/0218A61B90/98A61B2018/00041A61B2018/00172A61B2018/00541A61B2018/00577A61B2018/00642A61B2018/00714A61B2018/00744A61B2018/00761A61B2018/00791A61B2018/00863A61B2018/00988A61B2018/0212A61B2018/0231
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Quick Facts
Patent No.
US 11,963,709
App. No.
16/663,773
Granted
Apr 23, 2024
Kind
B2
Abstract

A method and system for automated and semi-automated predictable, consistent, safe, effective, and lumen-specific and patient-specific cryospray treatment of airway tissue in which treatment duration is automatically set by the system following entry of patient information and treatment location information into the system by the user, and treatment spray is automatically stopped by the system when the automatically selected treatment duration has been achieved as determined by the system.

Claims (30)

1. A method of reducing mucous production in an airway of a patient comprising:

advancing a flexible endoscope through an airway passage;

inserting a flexible cryospray catheter through a working channel of the endoscope and toward a target tissue of a bronchial tree of a respiratory tract, wherein the target tissue comprises goblet cells;

calculating a metered amount of cryospray configured to generate a primarily regenerative response when applied to the target tissue comprising the goblet cells in the bronchial tree of the respiratory tract; and

automatically supplying the metered amount of cryospray through the catheter.

2. The method of claim 1 , wherein supplying the cryospray through the catheter is configured to reduce an amount of functioning goblet cells in the target tissue.

3. The method of claim 1 , wherein the target tissue is a pre-identified region within the patient.

4. The method of claim 1 , wherein the target tissue is a bronchi.

5. The method of claim 1 , wherein the target tissue is a principal bronchi.

6. The method of claim 1 , further comprising relocating the catheter to another target tissue.

7. A method of reducing mucous production in an airway of a patient comprising:

advancing a flexible endoscope through a trachea;

inserting a flexible cryospray catheter through a working channel of the endoscope and toward a target tissue of a bronchial tree of a respiratory tract, wherein the target tissue comprises mucosal tissue, the catheter having at least one radial aperture;

calculating a metered amount of cryospray configured to generate a primarily regenerative response when applied to the target tissue comprising the mucosal tissue in the bronchial tree of the respiratory tract; and

automatically supplying the metered amount of cryospray through the catheter.

8. The method of claim 7 , wherein supplying the cryospray through the catheter is configured to reduce an amount of functioning goblet cells in the target tissue.

9. The method of claim 7 , wherein the target tissue is a pre-identified region within the patient.

10. The method of claim 7 , wherein the target tissue is within a bronchi of the patient.

11. The method of claim 7 , wherein the target tissue is within a principal bronchi of the patient.

12. The method of claim 7 , further comprising relocating the catheter to another target tissue.

13. A method of reducing over-proliferating goblet cells in an airway of a patient comprising:

advancing a flexible endoscope through an airway passage;

inserting a flexible catheter through a working channel of the endoscope and toward a target tissue site in a bronchial tree of a respiratory tract;

calculating a metered amount of cryospray configured to generate a primarily regenerative response when applied to the target tissue in the bronchial tree of the respiratory tract; and

automatically supplying the metered amount of cryospray through the catheter; and

remodeling the target tissue to reduce a goblet cell count of the target tissue.

14. The method of claim 13 , wherein the target tissue is a pre-identified region within the patient.

15. The method of claim 13 , wherein the target tissue is within a bronchi of the patient.

16. The method of claim 13 , wherein the target tissue is within a principal bronchi of the patient.

17. The method of claim 13 , further comprising relocating the catheter to another target tissue.

Assignments (8)
SECURITY INTEREST Recorded Apr 29, 2024
From: CSA MEDICAL, INC.
To: SYMARK LLC; CHV III, L.P.; SV LIFE SCIENCES FUND V, L.P.; SV LIFE SCIENCES FUND V, STRATEGIC PARTNERS, L.P.; INTERSOUTH PARTNERS VII, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V-A, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V-C, L.P.; BHCM CSA MEDICAL, LLC; ALFRED M. RANKIN, JR. TRUST; BENMIKE INVESTMENT CO. LLC; CHARLES G. BROWN, INC.; CLAIBORNE R. RANKIN REVOCABLE TRUST U/A/D 6/22/71; BROWN, DAVID P.; INKLEY, E. DALE; COWELL, ENSIGN; EVERGREEN VENTURES LTD; KRONEBERGER, G. BRIAN, JR.; LINCOLN, G. RUSSELL; G. RUSSELL LINCOLN REVOCABLE TRUST DTD 10/31/2007; GUIDE MEDICAL VENTURES, LLC; H&B INVESTMENT PARTNERSHIP; MAHONEY, JAMES J., JR.; DAVIDSON, MARC S.; DYER, MARK V.; MEDTECH INVESTMENTS, LLC; ELLIS, MICHAEL A.; MWK TRUST, MIRIAM WINDER-KELLY TTE; SMITH, NATHANIEL T.; MARY T. VON HERRMANN FAMILY TRUST; SCHWARTZ, RICHARD T.; PECK, STEVEN E.; SCHAEFER, STEVEN E.; SYCAMORE FUND 1, LLC; TIMOTHY T WEGLICKI RESTATED REVOCABLE TRUST U/A DTD 9-13-2022 AS AMENDED AND RESTATED DURING LIFETIME OF TIMOTHY T WEGLICKI; MELITA, TOM; VICTOIRE G. RANKIN TRUST; WILLIAM E. CONWAY UTA DATED 12/12/80 AS AMENDED
Reel/Frame 067249/0383 →
NUNC PRO TUNC ASSIGNMENT Recorded Apr 5, 2024
From: CSA MEDICAL, INC.
To: CHV III, L.P.; SV LIFE SCIENCES FUND V.I.P.; SV LIFE SCIENCES FUND V. STRATEGIC PARTNERS, L.P.; INTERSOUTH PARTNERS VII, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V-A, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V-C, L.P.; BHCM CSA MEDICAL, L.L.C.; ALFRED M. RANKIN, JR. TRUST; BENMIKE INVESTMENT CO. LLC; CHARLES G. BROWN, INC.; CLAIBORNE R. RANKIN REVOCABLE TRUST U/A/D 6/22/71; BROWN, DAVID P., MR.; INKLEY, E. DALE; COWELL, ENSIGN; EVERGREEN VENTURES LTD; KRONEBERGER,, G. BRIAN, JR.; LINCOLN, G. RUSSELL; G. RUSSELL LINCOLN REVOCABLE TRUST DTD 10/31/2007; GUIDE MEDICAL VENTURES, L.L.C.; H&B INVESTMENT PARTNERSHIP; MAHONEY, JAMES J., JR.; DAVIDSON, MARC S.; DYER, MARK V.; MEDTECH INVESTMENTS, LLC; ELLIS, MICHAEL A.; MWK TRUST, MIRIAM WINDER-KELLY TTE; SMITH, NATHANIEL T.; MARY T. VON HERRMANN FAMILY TRUST; SCHWARZ, RICHARD T.; PECK, STEVEN E.; SCHAEFER, STEVEN E.; SYCAMORE FUND 1, LLC; SYMARK LLC; TIMOTHY T. WEGLICKI RESTATED RECOVABLE TRUST U/A DTD 9-13-2022 AS AMENDED AND RESTATED DURING LIFETIME OF TIMOTHY T WEGLICKI; MELITA, TOM; VICTORIE G. RANKIN TRUST; WILLIAM E. CONWAY UTA DATED 12/12/80 AS AMENDED
Reel/Frame 067025/0210 →
SECURITY INTEREST Recorded Jan 25, 2024
From: CSA MEDICAL, INC.
To: CHV III, L.P.; SV LIFE SCIENCES FUND V, STRATEGIC PARTNERS, L.P.; SV LIFE SCIENCES FUND V, L.P.; INTERSOUTH PARTNERS VII, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V-A, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V-C, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V, L.P.; BHCM CSA MEDICAL, LLC; ALFRED M. RANKIN, JR. TRUST; BENMIKE INVESTMENT CO. LLC; CHARLES G. BROWN, INC.; CLAIBORNE R. RANKIN REVOCABLE TRUST U/A/D 6/22/71; BROWN, DAVID P.; INKLEY, E. DALE; COWELL, ENSIGN; EVERGREEN VENTURES LTD; KRONEBERGER, G. BRIAN, JR.; G. RUSSELL LINCOLN REVOCABLE TRUST DTD 10/31/2007; LINCOLN, G. RUSSELL; GUIDE MEDICAL VENTURES, LLC; H&B INVESTMENT PARTNERSHIP; MAHONEY, JAMES J., JR.; DAVIDSON, MARC S.; DYER, MARK V.; MEDTECH INVESTMENTS, LLC; ELLIS, MICHAEL A.; MWK TRUST, MIRIAM WINDER-KELLY TTE; SMITH, NATHANIEL T.; MARY T. VON HERRMANN FAMILY TRUST; SCHWARTZ, RICHARD T.; PECK, STEVEN E.; SCHAEFER, STEVEN E.; SYCAMORE FUND 1, LLC; SYMARK LLC; TIMOTHY T WEGLICKI RESTATED REVOCABLE TRUST U/A DTD 9-13- 2022 AS AMENDED AND RESTATED DURING LIFETIME OF TIMOTHY T WEGLICKI; MELITA, TOM; VICTOIRE G. RANKIN TRUST; WILLIAM E. CONWAY UTA DATED 12/12/80 AS AMENDED
Reel/Frame 066242/0249 →
SECURITY INTEREST Recorded Sep 20, 2023
From: CSA MEDICAL, INC.
To: CHV III, L.P.; SV LIFE SCIENCES FUND V, STRATEGIC PARTNERS, L.P.; SV LIFE SCIENCES FUND V, L.P.; INTERSOUTH PARTNERS VII, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V-A, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V-C, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V, L.P.; BHCM CSA MEDICAL, LLC; ALFRED M. RANKIN, JR. TRUST; BENMIKE INVESTMENT CO. LLC; CHARLES G. BROWN, INC.; CLAIBORNE R. RANKIN REVOCABLE TRUST U/A/D 6/22/71; BROWN, DAVID P.; INKLEY, E. DALE; COWELL, ENSIGN; EVERGREEN VENTURES LTD; KRONEBERGER, G. BRIAN, JR.; G. RUSSELL LINCOLN REVOCABLE TRUST DTD 10/31/2007; LINCOLN, G. RUSSELL; GUIDE MEDICAL VENTURES, LLC; H&B INVESTMENT PARTNERSHIP; MAHONEY, JAMES J., JR.; DAVIDSON, MARC S.; MEDTECH INVESTMENTS, LLC; ELLIS, MICHAEL A.; MWK TRUST, MIRIAM WINDER-KELLY TTE; SMITH, NATHANIEL T.; MARY T. VON HERRMANN FAMILY TRUST; SCHWARZ, RICHARD T.; SCHAEFER, STEVEN E.; PECK, STEVEN E.; SYCAMORE FUND 1, LLC; SYMARK LLC; WEGLICKI, TIMOTHY T.; MELITA, TOM; VICTOIRE G. RANKIN TRUST; WILLIAM E. CONWAY UTA DATED 12/12/80 AS AMENDED; DYER, MARK V.
Reel/Frame 064963/0228 →
SECURITY INTEREST Recorded Apr 28, 2023
From: CSA MEDICAL, INC.
To: CHV III, L.P.; SV LIFE SCIENCES FUND V, L.P.; SV LIFE SCIENCES FUND V, STRATEGIC PARTNERS, L.P.; INTERSOUTH PARTNERS VII, L.P.; MATHERS ASSOCIATES; BHCM CSA MEDICAL, LLC; ALFRED M. RANKIN, JR. TRUST; BENMIKE INVESTMENT CO. LLC; CHARLES G. BROWN, INC.; CLAIBORNE R. RANKIN REVOCABLE TRUST U/A/D 6/22/71; BROWN, DAVID P.; INKLEY, E. DALE; COWELL, ENSIGN; EVERGREEN VENTURES LTD; KRONEBERGER, G. BRIAN, JR.; LINCOLN, G. RUSSELL; G. RUSSELL LINCOLN REVOCABLE TRUST DTD 10/31/2007; GUIDE MEDICAL VENTURES, LLC; H&B INVESTMENT PARTNERSHIP; MAHONEY, JAMES J.; DAVIDSON, MARC S.; DYER, MARK V.; MEDTECH INVESTMENTS, LLC; ELLIS, MICHAEL A.; MWK TRUST, MIRIAM WINDER-KELLY TTE; SMITH, NATANIEL T.; HERMANN, TIM VON; SCHWARZ, RICHARD T.; PECK, STEVEN E.; SCHAEFER, STEVEN E.; SYCAMORE FUND 1, LLC; SYMARK LLC; WEGLICKI, TIMOTHY T.; MELITA, TOM; VICTOIRE G. RANKIN TRUST; WILLIAM E. CONWAY UTA DATED 12/12/80 AS AMENDED
Reel/Frame 063474/0974 →
SECURITY INTEREST Recorded Dec 16, 2022
From: CSA MEDICAL, INC.
To: CHV III, L.P.; SV LIFE SCIENCES FUND V, L.P.; SV LIFE SCIENCES FUND V, STRATEGIC PARTNERS, L.P.; INTERSOUTH PARTNERS VII, L.P.; MATHERS ASSOCIATES; DISRUPTIVE INNOVATION FUND, LP; BHCM CSA MEDICAL, LLC; ALFRED M. RANKIN, JR. TRUST; BENMIKE INVESTMENT CO. LLC; CHARLES G. BROWN, INC.; CLAIBORNE R. RANKIN REVOCABLE TRUST U/A/D 6/22/71; BROWN, DAVID P; INKLEY, E. DALE; COWELL, ENSIGN; EVERGREEN VENTURES LTD; KRONEBERGER, G. BRIAN, JR.; LINCOLN, G. RUSSELL; G. RUSSELL LINCOLN REVOCABLE TRUST DTD 10/31/2007; GUIDE MEDICAL VENTURES, LLC; H&B INVESTMENT PARTNERSHIP; MAHONEY, JAMES J, JR.; DAVIDSON, MARC S; DYER, MARK V.; MEDTECH INVESTMENTS, LLC; ELLIS, MICHAEL A; MWK TRUST, MIRIAM WINDER-KELLY TTE; SMITH, NATHANIEL; NATIONAL FINANCIAL SERVICES/ FIDELITY INVESTMENTS CUSTODIAN FBO STEVEN E. SCHAEFER IRA; HERMANN, TIM VON; SCHWARZ, RICHARD T; PECK, STEVEN E.; SCHAEFER, STEVEN E.; SYCAMORE FUND 1, LLC; SYMARK LLC; WEGLICKI, TIMOTHY T.; MELITA, TOM; VICTOIRE G. RANKIN TRUST; WILLIAM E. CONWAY UTA DATED 12/12/80 AS AMENDED
Reel/Frame 062132/0359 →
SECURITY INTEREST Recorded Mar 13, 2020
From: CSA MEDICAL, INC.
To: CHV III, L.P.; SV LIFE SCIENCES FUND V, L.P.; SV LIFE SCIENCES FUND V, STRATEGIC PARTNERS, L.P.; INTERSOUTH PARTNERS VII, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V-A, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V, L.P.; FIRST ANALYSIS PRIVATE EQUITY FUND V-C, L.P.; MATHERS ASSOCIATES; DISRUPTIVE INNOVATION FUND, LP; BHCM CSA MEDICAL, LLC; SYMARK LLC; ALFRED M. RANKIN, JR. TRUST; BENMIKE INVESTMENT CO. LLC; CLAIBORNE R. RANKIN REVOCABLE TRUST U/A/D 6/22/71; EVERGREEN VENTURES LTD; KRONEBERGER, G. BRIAN; GUIDE MEDICAL VENTURES, LLC; H&B INVESTMENT PARTNERSHIP; MEDTECH INVESTMENTS, LLC; ELLIS, MICHAEL A; MWK TRUST, MIRIAM WINDER-KELLY TTE; SCHWARZ, RICHARD T; SCHAEFER, STEVEN E.; SYCAMORE FUND 1, LLC; MELITA, TOM; VICTOIRE G. RANKIN TRUST
Reel/Frame 052105/0773 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 5, 2020
From: MANNERS, WENDELIN; SHEETS, ELLEN; CORDERO, RAFAEL; DAVIDSON, MARC; FAN, WEI LI; SHERRILL, DAVID; HANLEY, BRIAN M.; SARLI, AMY; GRIFFIN, STEPHEN; HAWKES, HEATHER V.
To: CSA MEDICAL, INC.
Reel/Frame 051417/0259 →
Continuity (4)
Continuation 14731359 · Jun 4, 2015
Provisional Application 62007518 · Jun 4, 2014
Provisional Application 62047936 · Sep 9, 2014
Related Publication 20200054380A1 · Feb 20, 2020