Nasal drug delivery device
A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.
1. A device for delivery of a compound to a nasal cavity, the device comprising:
an air compression chamber;
a manual pressure actuator that causes air to be released from the air compression chamber upon actuation;
a diffuser in communication with the air compression chamber;
a drug chamber in communication with the diffuser and a diffusion tube, the drug chamber configured to hold the compound and the diffusion tube allowing for the released air to bypass the compound; and
a nozzle in communication with the drug chamber, wherein air released from the air compression chamber is configured to flow through the diffuser to contact and propel the compound out of the nozzle forming a plume.
2. The device of claim 1 , wherein the manual pressure actuator further comprises a lock pin, wherein the lock pin is configured to maintain high pressure air in the air compression chamber.
3. The device of claim 1 , further comprising a trigger valve in communication with the air compression chamber such that when the trigger valve is rotated from an open state to a closed state, air in the air compression chamber is blocked from contacting the diffuser and propelling the compound out of the nozzle.
4. The device of claim 1 , wherein the manual pressure actuator comprises a piston.
5. The device of claim 1 , wherein the manual pressure actuator comprises a syringe.
6. The device of claim 1 , wherein the manual pressure actuator comprises a syrette.
7. The device of claim 1 , wherein the diffuser is heterogeneously porous or homogenously porous.
8. The device of claim 1 , wherein the compound is a drug or diagnostic agent.
9. The device of claim 8 , wherein the diagnostic agent is an imaging agent.
10. The device of claim 1 , wherein the diffuser is porous, the porous diffuser being a disk-shaped member including at least one conical shaped member having a distal aperture.
11. The device of claim 1 , wherein the diffuser is configured to act as a one-way check valve.
12. The device of claim 1 , wherein the diffuser extends into the compound in the drug chamber.
13. A device for delivering a compound to a nasal cavity, the device comprising:
an air compression chamber;
a manual pressure actuator comprising a lock pin, the manual pressure actuator configured to release air from the air compression chamber, the lock pin configured to maintain high pressure air in the air compression chamber;
a trigger valve configured to be in communication with the air compression chamber such that when the trigger valve is rotated from an open state to a closed state, air in the air compression chamber is blocked from exiting the air compression chamber;
a diffuser in communication with the trigger valve;
a drug chamber in communication with the diffuser and a diffusion tube, the drug chamber configured to hold the compound and the diffusion tube allowing for the released air to bypass the compound; and
a nozzle in communication with the drug chamber, wherein air released from the air compression chamber is configured to flow through the diffuser to contact and propel the compound out of the nozzle forming a plume.
14. The device of claim 13 , wherein the manual pressure actuator further comprises a piston.
15. The device of claim 13 , wherein the manual pressure actuator further comprises a syringe.
16. The device of claim 13 , wherein the manual pressure actuator further comprises a syrette.
17. The device of claim 13 , wherein the diffuser is heterogeneously porous or homogenously porous.
18. The device of claim 13 , wherein the diffuser is configured to act as a one-way check valve.
19. The device of claim 13 , wherein the diffuser is porous, the porous diffuser being a disk-shaped member including at least one conical shaped member having a distal aperture.
20. The device of claim 13 , wherein the diffuser extends into the compound in the drug chamber.