IP Library Granted Patent US 10,869,869
Granted Patent B2
US 10,869,869 · App. 16/664,978 · Granted Dec 22, 2020

Method of adjuvant cancer treatment

Inventors: Sylvie Laquerre (King of Prussia, PA); Peter F. Lebowitz (Research Triangle Park, NC)
Assignee: Novartis AG
A61K31/519A61K31/506
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Quick Facts
Patent No.
US 10,869,869
App. No.
16/664,978
Granted
Dec 22, 2020
Kind
B2
Abstract

The present invention provides a method of providing adjuvant treatment to a human patient which comprises administering to such a patient therapeutically effective doses of dabrafenib and trametinib for a time period sufficient to increase relapse-free survival (RFS).

Claims (5)

1. A method for providing adjuvant treatment to a patient with a prior diagnosis of melanoma which has been resected, comprising the steps of:

a) administering to said patient therapeutically effective doses of dabrafenib and trametinib, wherein said dabrafenib is administered at an amount of 150 mg twice a day and said trametinib is administered at an amount of 2 mg once daily; and

b) increasing relapse-free (RFS) of said patient after resection of said melanoma.

2. The method of claim 1 , wherein said patient has a prior diagnosis of stage III melanoma, which has been resected.

3. The method of claim 1 , wherein said patient has a prior diagnosis of BRAF V600 mutation-positive melanoma, which has been resected.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 5, 2023
From: NOVARTIS AG
To: NOVARTIS PHARMACEUTICALS CORPORATION
Reel/Frame 065762/0911 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 15, 2021
From: GLAXO GROUP LIMITED
To: NOVARTIS PHARMA AG
Reel/Frame 055009/0001 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CORRECT AN ERROR IN EXECUTION DATE PREVIOUSLY RECORDED AT REEL: 053839 FRAME: 0531. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Nov 11, 2020
From: GLAXOSMITHKLINE LLC
To: GLAXO GROUP LIMITED
Reel/Frame 054385/0205 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2020
From: LAQUERRE, SYLVIE; LEBOWITZ, PETER F
To: GLAXOSMITHKLINE LLC
Reel/Frame 053792/0772 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2020
From: NOVARTIS PHARMA AG
To: NOVARTIS AG
Reel/Frame 053797/0138 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2020
From: GLAXOSMITHKLINE LLC
To: GLAXO GROUP LIMITED
Reel/Frame 053839/0531 →