Alleviating oxidative stress disorders with PUFA derivatives
Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD).
1. A compound of formula:
wherein R is H, alkyl, or a cation; and
each Y is D.
2. The compound of claim 1 , wherein R is H.
3. The compound of claim 1 , wherein R is ethyl.
4. A pharmaceutical composition comprising a compound of formula:
wherein R is H, alkyl, or a cation; and
each Y is D.
5. The composition of claim 4 , wherein R is H.
6. The composition of claim 4 , wherein R is ethyl.