Drug eluting matrix on analyte indicator
A sensor that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing and an analyte indicator covering at least a portion of the sensor housing. The sensor may include a drug-eluting matrix that covers at least a portion of the analyte indicator. The drug-eluting matrix may include one or more openings configured to allow the medium to pass through the drug-eluting matrix and come into contact with the analyte indicator. The sensor may include one or more therapeutic agents. The one or more therapeutic agents may reduce deterioration of the analyte indicator. The one or more therapeutic agents may be incorporated within the drug-eluting matrix.
1. A sensor for measurement of an analyte in a medium within a living animal, the sensor comprising:
a sensor housing;
an analyte indicator covering at least a portion of the sensor housing, wherein the analyte indicator comprises one or more indicator molecules that reversibly bind the analyte and exhibit a detectable property indicative of whether the analyte is bound;
a drug-eluting matrix that covers only a portion of the analyte indicator, wherein the drug-eluting matrix includes one or more openings configured to allow the medium to pass through the drug-eluting matrix and come into contact with the analyte indicator, and the one or more openings of the drug-eluting matrix result in the drug-eluting matrix not covering one or more portions of the analyte indicator; and
one or more therapeutic agents that reduce deterioration of the analyte indicator and are dispersed within the drug-eluting matrix.
2. The sensor of claim 1 , wherein the sensor is implantable within a living animal.
3. The sensor of claim 1 , wherein the drug-eluting matrix covers at least a portion of the sensor housing.
4. The sensor of claim 1 , wherein the druq-elutinq matrix is a druq-elutinq polymer matrix, and wherein one or more of the therapeutic agents are incorporated within the drug-eluting polymer matrix via one or more covalent bonds that break in the presence of aqueous media and release the one or more therapeutic agents.
5. The sensor of claim 1 , wherein the druq-elutinq matrix is a druq-elutinq polymer matrix, and wherein one or more of the therapeutic agents are incorporated within the drug-eluting polymer matrix via one or more covalent bonds that break through exposure to light and release the one or more therapeutic agents.
6. The sensor of claim 5 , further comprising a light source, wherein the covalent bonds break through exposure to light emitted by the light source.
7. The sensor of claim 1 , wherein the one or more therapeutic agents include an anti-inflammatory drug.
8. The sensor of claim 7 , wherein the anti-inflammatory drug is a non-steroidal anti-inflammatory drug.
9. The sensor of claim 8 , wherein the non-steroidal anti-inflammatory drug is acetylsalicylic acid.
10. The sensor of claim 8 , wherein the non-steroidal anti-inflammatory drug is isobutylphenylpropanoic acid.
11. The sensor of claim 1 , wherein the one or more therapeutic agents include a glucocorticoid.
12. The sensor of claim 1 , wherein the one or more therapeutic agents include one or more of dexamethasone, triamcinolone, betamethasone, methylprednisolone, beclometasone, fludrocortisone, derivatives thereof, and analogs thereof.
13. The sensor of claim 1 , wherein the one or more therapeutic agents reduce oxidation of the analyte indicator.
14. The sensor of claim 1 , wherein the analyte indicator is a graft including indicator molecules.
15. The sensor of claim 1 , further comprising a layer of a catalyst capable of converting hydrogen peroxide into water and oxygen on at least a portion of the analyte indicator.
16. The sensor of claim 1 , further comprising:
a light source within the sensor housing configured to emit excitation light; and
a photodetector within the sensor housing, wherein the photodetector is sensitive to light emitted by the one or more indicator molecules and configured to generate a signal indicative of the amount of the analyte in the medium within the living animal.
17. The sensor of claim 1 , wherein the one or more openings comprise a plurality of openings.
18. The sensor of claim 1 , wherein the one or more openings comprise one or more openings having a circular, oval, square, pear, or diamond shape.
19. The sensor of claim 1 , wherein the one or more openings comprise relatively large openings and relatively small openings.
20. The sensor of claim 1 , wherein the one or more openings comprise rows of openings.