Analyte monitoring systems and methods that make use of information about a condition of the environment surrounding an analyte sensor
An analyte monitoring system may include an analyte sensor and a transceiver. The analyte sensor may include: a sensor housing, an analyte indicator on at least a portion of the sensor housing, a protective material on at least a portion of the analyte indicator, and a light source in the sensor housing and configured to emit excitation light to analyte indicator. The transceiver may be configured to receive the sensor measurements conveyed by the analyte sensor, infer information about a condition of the environment surrounding the analyte sensor, and calculate an analyte level using at least one or more of the sensor measurements and the inferred information about the condition of the environment surrounding the sensor. The protective material may have a thickness that is thin enough to allow at least some of the excitation light to pass through the protective material and into the environment surrounding the analyte sensor.
1. An analyte monitoring system comprising:
an analyte sensor comprising: (i) a sensor housing, (ii) an analyte indicator on at least a portion of the sensor housing and configured to emit an amount of light indicative of an analyte level in a first medium in proximity to the analyte indicator, (iii) a protective material on at least a portion of the analyte indicator and configured to reduce degradation of the analyte indicator by catalytically decomposing or inactivating one or more in vivo reactive oxygen species or biological oxidizers, (iv) a light source in the sensor housing and configured to emit excitation light to the analyte indicator, (v) a signal photodetector in the sensor housing and configured to receive the amount of light emitted by the analyte indicator and generate a measurement signal indicative of the amount of light emitted by the analyte indicator and received by the signal photodetector, (vi) a reference photodetector in the sensor housing and configured to generate a reference signal indicative of an amount of the excitation light received by the reference photodetector, and (vii) a transceiver interface configured to convey sensor measurements including one or more measurements of the measurement signal and one or more measurements of the reference signal; and
a transceiver comprising: (i) a sensor interface configured to receive the sensor measurements conveyed by the analyte sensor and (ii) a processor configured to infer information about a condition of the environment surrounding the analyte sensor using at least one or more of the sensor measurements and to calculate an analyte level in a second medium using at least one or more of the sensor measurements and the inferred information about the condition of the environment surrounding the analyte sensor;
wherein the excitation light received by the reference photodetector includes light that was emitted by the light source, passed through the analyte indicator and the protective material, and was reflected by the environment surrounding the analyte sensor;
wherein the environment surrounding the analyte sensor includes one or more of tissue, blood, and clotting.
2. The analyte monitoring system of claim 1 , wherein said inferring the information about the condition of the environment surrounding the analyte sensor comprises estimating a state of a wound healing process in tissue surrounding the analyte sensor.
3. The analyte monitoring system of claim 1 , wherein said calculating the analyte level in the second medium using at least the one or more of the sensor measurements and the inferred information about the condition of the environment surrounding the analyte sensor comprises:
adjusting one or more parameters of a conversion function based on at least the inferred information about the condition of the environment surrounding the analyte sensor; and
using the adjusted conversion function and the one or more of the sensor measurements to calculate the analyte level in the second medium.
4. The analyte monitoring system of claim 3 , wherein said adjusting one or more parameters of the conversion function comprises adjusting an analyte diffusion rate parameter and/or an analyte consumption rate parameter.
5. The analyte monitoring system of claim 1 , wherein said calculating the analyte level in the second medium using at least the one or more of the sensor measurements and the inferred information about the condition of the environment surrounding the analyte sensor comprises:
selecting a conversion function based on at least the inferred information about the condition of the environment surrounding the analyte sensor; and
using the selected conversion function and the one or more of the sensor measurements to calculate the analyte level in the second medium.
6. The analyte monitoring system of claim 1 , wherein the protective material is sputtered on the analyte indicator.
7. The analyte monitoring system of claim 1 , wherein the protective material comprises platinum.
8. The analyte monitoring system of claim 1 , wherein the protective material has a thickness in a range from 1 nm to 20 nm.
9. The analyte monitoring system of claim 1 , wherein the protective material has a thickness in a range from 3 nm to 6 nm.
10. The analyte monitoring system of claim 1 , wherein the protective material has a thickness in a range from 8 nm to 12 nm.
11. The analyte monitoring system of claim 10 , wherein the protective material has a thickness of 10 nm.
12. A method comprising:
using a light source in a sensor housing of an analyte sensor to emit excitation light to an analyte indicator on at least a portion of the sensor housing;
using the analyte indicator to emit an amount of light indicative of an analyte level in a first medium in proximity to the analyte indicator;
using a protective material on at least a portion of the analyte indicator to reduce degradation of the analyte indicator by catalytically decomposing or inactivating one or more in vivo reactive oxygen species or biological oxidizers;
using a signal photodetector in the sensor housing to receive the amount of light emitted by the analyte indicator and generate a measurement signal indicative of the amount of light emitted by the analyte indicator and received by the signal photodetector;
using a reference photodetector in the sensor housing to generate a reference signal indicative of an amount of the excitation light received by the reference photodetector, wherein the excitation light received by the reference photodetector includes light that was emitted by the light source, passed through the analyte indicator and the protective material, and was reflected by the environment surrounding the analyte sensor, and the environment surrounding the analyte sensor includes one or more of tissue, blood, and clotting;
using a transceiver interface of the analyte sensor to convey sensor measurements including one or more measurements of the measurement signal and one or more measurements of the reference signal;
using a sensor interface of a transceiver to receive the sensor measurements conveyed by the analyte sensor; and
using a processor of the transceiver to infer information about a condition of the environment surrounding the analyte sensor using at least one or more of the sensor measurements and to calculate an analyte level in a second medium using at least one or more of the sensor measurements and the inferred information about the condition of the environment surrounding the analyte sensor.
13. The method of claim 12 , wherein said inferring the information about the condition of the environment surrounding the analyte sensor comprises estimating a state of a wound healing process in tissue surrounding the analyte sensor.
14. The method of claim 12 , wherein said calculating the analyte level in the second medium using at least the one or more of the sensor measurements and the inferred information about the condition of the environment surrounding the analyte sensor comprises:
adjusting one or more parameters of a conversion function based on at least the inferred information about the condition of the environment surrounding the analyte sensor; and
using the adjusted conversion function and the one or more of the sensor measurements to calculate the analyte level in the second medium.
15. The method of claim 14 , wherein said adjusting one or more parameters of the conversion function comprises adjusting an analyte diffusion rate parameter and/or an analyte consumption rate parameter.
16. The method of claim 12 , wherein said calculating the analyte level in the second medium using at least the one or more of the sensor measurements and the inferred information about the condition of the environment surrounding the analyte sensor comprises:
selecting a conversion function based on at least the inferred information about the condition of the environment surrounding the analyte sensor; and
using the selected conversion function and the one or more of the sensor measurements to calculate the analyte level in the second medium.
17. The method of claim 12 , wherein the protective material is sputtered on the analyte indicator.
18. The method of claim 12 , wherein the protective material comprises platinum.
19. The method of claim 12 , wherein the protective material has a thickness in a range from 1 nm to 20 nm.
20. The method of claim 12 , wherein the protective material has a thickness in a range from 3 nm to 6 nm.
21. The method of claim 12 , wherein the protective material has a thickness in a range from 8 nm to 12 nm.
22. The method of claim 21 , wherein the protective material has a thickness of 10 nm.