Compositions for drug administration
The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at least one alkyl glycoside and at least one therapeutic agent, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.
1. A method of treating a condition ameliorated by epinephrine in a subject, said method comprising intranasally administering to the subject in need thereof a composition consisting of: a) epinephrine, b) an alkylglycoside, and c) inactive excipients,
wherein the alkylglycoside has an alkyl chain including between 8 to 20 carbons and the alkylglycoside concentration is between about 0.001% and 10.0% (w/v),
wherein the composition is an aqueous solution formulated for intranasal delivery to the subject.
2. The method of claim 1 , wherein the alkylglycoside is selected from the group consisting of undecyl maltoside, dodecyl maltoside, tridecyl maltoside, tetradecyl maltoside, sucrose mono-dodecanoate, sucrose mono-tridecanoate, and sucrose mono-tetradecanoate.
3. The method of claim 2 , wherein the alkylglycoside is dodecyl-beta-D-maltoside.
4. The method of claim 1 , wherein the alkylglycoside concentration is between about 0.05% and 0.5% (w/v).
5. The method of claim 1 , wherein the composition provides a Cmax for the epinephrine in the subject that is about 2 fold or greater as compared to administration without alkylglycoside.
6. The method of claim 1 , wherein the composition provides a Tmax for the epinephrine in the subject that is about 2 fold or less as compared to administration without alkylglycoside.
7. The method of claim 1 , wherein the composition provides a Tmax for the epinephrine of about 0.3 hours or less in the subject.
8. The method of claim 1 , wherein the composition has a pH of about 2.0 to 5.0.
9. The method of claim 1 , wherein the inactive excipients are selected from citric acid, sodium citrate, propylene glycol, glycerin, ascorbic acid, sodium metabisulfite, ethylenediaminetetraacetic acid (EDTA) disodium, benzalkonium chloride, sodium hydroxide, or a combination thereof.
10. The method of claim 1 , wherein the inactive excipients are selected from benzalkonium chloride, EDTA, or a combination thereof.