Use of secoisolariciresinol diglucosides (SDGS) and related compounds for protection against radiation and chemical damage

Inventor: Melpo Christofidou-Solomidou (Eagleville, PA)

Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

A61K31/7032 A61K31/05 A61K31/09 A61K31/365

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Quick Facts

Patent No.: US 10,966,995
App. No.: 16/678,734
Granted: Apr 6, 2021
Kind: B2

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Abstract

The invention provides compositions and methods for radioprotection and chemoprevention using therapeutic and prophylactics methods of using (S,S)-SDG (R,R)-SDG, (S,R)-SDG (R,S)-SDG, SDG, SECO, EL, ED, analogs thereof, stereoisomers thereof and other related molecules.

Claims (9)

1. A method for treating asthma in a subject in need thereof, the method comprising: administering to the subject a therapeutically effective amount of secoisolaricirecinol diglucoside (SDG).

2. The method of claim 1 , wherein the SDG is (S,S)-SDG.

3. The method of claim 1 , wherein the SDG is (R,R)-SDG.

4. The method of claim 1 , wherein the SDG is synthetic SDG.

5. The method of claim 1 , wherein the SDG is administered in a dietary composition.

6. The method of claim 1 , wherein administering comprises orally administering.

7. The method of claim 1 , wherein the SDG is in a concentration about 1 nanomolar (nM) to about 1 molar (M).

8. The method of claim 7 , wherein the SDG concentration is about 25 μM to about 250 μM.

9. The method of claim 1 , wherein the subject is a human subject.

Assignments (1)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2019

From: CHRISTOFIDOU-SOLOMIDOU, MELPO

To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Reel/Frame 050961/0385 →