IP Library › Patent Application 16680674
Patent Application
App. No. 16/680,674

METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS

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Quick Facts
Patent No.
US None
App. No.
16/680,674
Abstract

The present invention relates to new methods of manufacturing benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), and intermediates thereof.

Claims (7)

1 . A process of preparing a compound of Formula IV:

or a salt thereof, comprising:

a step of reacting a compound of Formula II or a salt thereof with a compound of Formula III:

in the presence of a base;

wherein:

R 7 -R 12 and R 15 are independently selected from the group consisting of hydrogen and deuterium; and

Y 1 is selected from the group consisting of acetoxy, alkoxy, halogen, haloalkoxy, perhaloalkoxy, heteroalkoxy, and aryloxy, any of which may be optionally substituted.